Protein Alignment tup and lhx1

DIOPT Version :10

• Sequence 1: NP_476775.1
• Gene: tup / 35147
• FlyBaseID: FBgn0003896
• Length: 534
• Species: Drosophila melanogaster
• Sequence 2: NP_001093698.1
• Gene: lhx1 / 100101708
• XenbaseID: XB-GENE-482482
• Length: 409
• Species: Xenopus tropicalis
• Alignment Length: 473
• Identity: 145/473 - (30%)
• Similarity: 194/473 - (41%)
• Gaps: 111/473 - (23%)

  Fly    53 HCVGCGGQIHDQYILRVAPDLEWHAACLKCQECRQFLDESCTCFVRDGKTYCKRDYVRLFGTKCD 117
            ||.||...|.|:::|.|. |..||..|::|.||:..|.|.  ||.|:||.|||.|:.|.|||||.
 Frog     3 HCAGCERPILDRFLLNVL-DRAWHVKCVQCCECKCNLTEK--CFSREGKLYCKNDFFRRFGTKCA 64

  Fly   118 KCGNSFSKNDFVMRAKTKIFHIECFRCSACARQLLPGDEFALRDAGALYCKEDHDVLEKSSQSSL 182
            .|....|.:|.|.||::|:||:.||.|..|.:||..|:|..:.|.....||||:
 Frog    65 GCAQGISPSDLVRRARSKVFHLNCFTCMMCNKQLSTGEELYIIDENKFVCKEDY----------- 118

  Fly   183 TSSSVESNNNISSSNNNNTNLSNNNHSSELGS-----------MSDSGSESGSHKSIRDKRPSGP 236
                  .|||    ||||.....|:..|..||           :.|...:|.| .:|.||. :|.
 Frog   119 ------LNNN----NNNNNAAKENSFISVTGSDPSLSPESQDPLQDDAKDSES-ANISDKE-AGV 171

  Fly   237 SD-------GKPTRVRTVLNEKQLHTLRTCYNANPRPDALMKEQLVEMTSLSPRVIRVWFQNKRC 294
            ::       .|....||.:..|||.||:..:.|.|:|...::|||.:.|.|:.|||:|||||:|.
 Frog   172 NENDDQNLGAKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRS 236

  Fly   295 KDKKKTIQMKLQMQQEKEGRKLGYGAMQGIPMIASSPVRH---DSPLNLQGLDVQTYQPPWKALS 356
            |:::        |:|                :.|....||   .||..::.| |...:|
 Frog   237 KERR--------MKQ----------------LSALGARRHAFFRSPRRMRPL-VDRLEP------ 270

  Fly   357 DFALHADLDSNGAINTHTPAFQQLVNQMHGYDLNGMPILPPHPHSHPAQGPPHQHPPPPGGPHNH 421
                 .:|..||..:.:.....:.......||     ..|..|.|..||.|......|..|
 Frog   271 -----GELIPNGPFSFYGDYQSEYYGPGSNYD-----FFPQGPPSSQAQTPVDLPFVPSSG---- 321

  Fly   422 QNQQPNQQPGGSSLDSGITSH----HHPDSTDSYVTYLES----DDKSKLALTPSSSSSASAGTS 478
                    |.|:.|  |...|    |||.|.....|.:.|    |..|.....|.|..|.||...
 Frog   322 --------PAGTPL--GAMDHPIPGHHPSSDAQRFTDIMSHPPGDSPSPEPNLPGSMHSMSAEVF 376

  Fly   479 ISSPP-SGVGAGGGGAVG 495
            ..||| |.:...|....|
 Frog   377 GQSPPFSSLSVNGAAGYG 394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tup	NP_476775.1	LIM1_Isl	54..108	CDD:188752	24/53 (45%)
		LIM2_Isl	116..171	CDD:188760	22/54 (41%)
		HOX	241..297	CDD:197696	25/55 (45%)
lhx1	NP_001093698.1	LIM1_Lhx1_Lhx5	4..55	CDD:188753	24/53 (45%)
		LIM2_Lhx1_Lhx5	63..118	CDD:188761	22/54 (41%)
		Homeodomain	184..240	CDD:459649	25/55 (45%)