Protein Alignment CG10602 and NPEPPS

DIOPT Version :10

• Sequence 1: NP_609916.5
• Gene: CG10602 / 35146
• FlyBaseID: FBgn0032721
• Length: 684
• Species: Drosophila melanogaster
• Sequence 2: NP_001398059.1
• Gene: NPEPPS / 9520
• HGNCID: 7900
• Length: 924
• Species: Homo sapiens
• Alignment Length: 594
• Identity: 148/594 - (24%)
• Similarity: 248/594 - (41%)
• Gaps: 108/594 - (18%)

  Fly    68 QKRNMGRLGV-VDPSSYS---QPDLITTEHSALNWKIDFAATKIQGSVLHRFKVLTANLDKILLD 128
            :||...||.. |.|.:||   :|||:   ......|::.||...|.:            ::|:::
Human    47 EKRPFERLPADVSPINYSLCLKPDLL---DFTFEGKLEAAAQVRQAT------------NQIVMN 96

  Fly   129 VRDINVTNATLLAGGSE----LPINFFISDAVDDIGQKLTLELPSGTAKGSLNVRIDY--ETSSS 187
            ..||::..|:....|.|    ...|:...|      :|:||..||....|:..::||:  |.:..
Human    97 CADIDIITASYAPEGDEEIHATGFNYQNED------EKVTLSFPSTLQTGTGTLKIDFVGELNDK 155

  Fly   188 ASGLQWLNPTQTLGKEHPYMFSQCQAIHARSVIPCQDTPAVKFTYDATVEHPSELTALMSA-LID 251
            ..|......|...|:......:|.:|..||...||.|.||:|.|:|.::..|.:..||.:. :||
Human   156 MKGFYRSKYTTPSGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVID 220

  Fly   252 KKE-PG-----KTLFKQEVPIPAYLVAIAIGKL--------------VSRPLGENSSVWAEEAIV 296
            :|. |.     :..|.:...:..||||..:|:.              |..|:|:     ||:.
Human   221 RKPYPDDENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGK-----AEQG-- 278

  Fly   297 DACAEEFSETATMLKTATELCGPYVWKQYDLLVMPPSFPFGGMEN-PCLTFVTPTLLAGDKS--- 357
            ....|..::|....|....:  ||...:.||:.: ..|..|.||| ..:|:....||...|:
Human   279 KFALEVAAKTLPFYKDYFNV--PYPLPKIDLIAI-ADFAAGAMENWGLVTYRETALLIDPKNSCS 340

  Fly   358 -----LADVVAHEIAHSWTGNLVTNKNFEHFWLNEGFTVFVESKIVGRMQGAKELDFKMLS-NLT 416
                 :|.||.||:||.|.|||||.:.:.|.||||||..::|...|.......::..:.:| :.|
Human   341 SSRQWVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYT 405

  Fly   417 DLQECIRTQLNKTPELTKLVVDLSNCGP---DDAFSSVPYIKGSTFLRYLEDLFGGPTVFEPFLR 478
            ..|| :....|..|      :::|...|   |:.|.::.|.||::.:|.|.|..|... |:..:.
Human   406 RAQE-LDALDNSHP------IEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKD-FKKGMN 462

  Fly   479 DYLKKYAYKSIETKDFQSALYDYFIDTDKKDKLSAVDWDLWLKSEGMPPVIPNF----DESLANV 539
            .||.|:..|:..|:|...:|      .:...|..|...:.|.|..|.|.:....    |:.|..:
Human   463 MYLTKFQQKNAATEDLWESL------ENASGKPIAAVMNTWTKQMGFPLIYVEAEQVEDDRLLRL 521

  Fly   540 TK-----------ELASLWS---SKSVAELADSAEIKTTISIHQLIDFLGKLIESKDIVDLNEGK 590
            ::           |....|.   :.|.:|..:.|::|..:...:: :.:.|.::....|.||.|.
Human   522 SQKKFCAGGSYVGEDCPQWMVPITISTSEDPNQAKLKILMDKPEM-NVVLKNVKPDQWVKLNLGT 585

  Fly   591 INLLESTYN 599
            :....:.|:
Human   586 VGFYRTQYS 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10602	NP_609916.5	Ribosomal_L13	15..>50	CDD:459856
		leuko_A4_hydro	79..681	CDD:274120	143/582 (25%)
NPEPPS	NP_001398059.1	M1_APN-Q_like	61..499	CDD:341064	125/482 (26%)
		ERAP1_C	578..854	CDD:463368	5/17 (29%)
		Nuclear localization signal. /evidence=ECO:0000255	726..730