Protein Alignment CG10602 and APE2

DIOPT Version :10

• Sequence 1: NP_609916.5
• Gene: CG10602 / 35146
• FlyBaseID: FBgn0032721
• Length: 684
• Species: Drosophila melanogaster
• Sequence 2: NP_012765.3
• Gene: APE2 / 853699
• SGDID: S000001640
• Length: 952
• Species: Saccharomyces cerevisiae
• Alignment Length: 694
• Identity: 170/694 - (24%)
• Similarity: 266/694 - (38%)
• Gaps: 164/694 - (23%)

  Fly    80 PSSYSQPDLITTEHSALNWKIDFAATKIQGSVLHRFKVLTANLDKILLDVRDINVTNATLLAGGS 144
            |:....||.:...|..|..:.||...|.:|||....|:....:|.:.|:..|.::.:|.:    .
Yeast    97 PNREILPDNVVPLHYDLTVEPDFKTFKFEGSVKIELKINNPAIDTVTLNTVDTDIHSAKI----G 157

  Fly   145 ELPINFFISDAVDDIGQKLTLELPSGTA---KGS--LNVRIDYETSSSASGLQWLNPTQTLGKEH 204
            ::..:..||   ::..|..|...|.||.   ||:  |:::.....:.:.:|.........|..|.
Yeast   158 DVTSSEIIS---EEEQQVTTFAFPKGTMSSFKGNAFLDIKFTGILNDNMAGFYRAKYEDKLTGET 219

  Fly   205 PYM-FSQCQAIHARSVIPCQDTPAVKFTYDATVEHPSELTALMSALIDKK----EPGK--TLFKQ 262
            .|| .:|.:...||...||.|.|.:|.::..|:.....||.|.:  :|.|    :.||  |||..
Yeast   220 KYMATTQMEPTDARRAFPCFDEPNLKASFAITLVSDPSLTHLSN--MDVKNEYVKDGKKVTLFNT 282

  Fly   263 EVPIPAYLVAIAIGKL--------------VSRPLGENSSVWAEEAIVDACAEEFSETATMLKTA 313
            ...:..||||..:.:|              .:.|..|....:|.:......| .|.:|..:
Yeast   283 TPKMSTYLVAFIVAELKYVESKNFRIPVRVYATPGNEKHGQFAADLTAKTLA-FFEKTFGI---- 342

  Fly   314 TELCGPYVWKQYDLLVMP----PSFPFGGMEN-PCLTF-VTPTLLAGDKS-------LADVVAHE 365
                      ||.|..|.    ..|..|.||| ..:|: |...||..|.|       :|:||.||
Yeast   343 ----------QYPLPKMDNVAVHEFSAGAMENWGLVTYRVVDLLLDKDNSTLDRIQRVAEVVQHE 397

  Fly   366 IAHSWTGNLVTNKNFEHFWLNEGFTVFV---------------ESKIVGRMQGAKELDFKMLSNL 415
            :||.|.|||||...:|..||||||..::               |..:...:|.|..||....|:
Yeast   398 LAHQWFGNLVTMDWWEGLWLNEGFATWMSWYSCNEFQPEWKVWEQYVTDTLQHALSLDSLRSSH- 461

  Fly   416 TDLQECIRTQLNKTPELTKLVVDLSNCGPDDAFSSVPYIKGSTFLRYLEDLFGGPTVFEPFLRDY 480
                 .|...:.|..|:.::            |.::.|.||::.||.:....|..| |...:..|
Yeast   462 -----PIEVPVKKADEINQI------------FDAISYSKGASLLRMISKWLGEET-FIKGVSQY 508

  Fly   481 LKKYAYKSIETKDFQSALYDYFIDTDKKDKLSAVDWDLWLKSEGMP------------------- 526
            |.|:.|.:.:|:|    |:|...|...||..|.:  ::|.|..|.|
Yeast   509 LNKFKYGNAKTED----LWDALADASGKDVRSVM--NIWTKKVGFPVISVSEDGNGKITFRQNRY 567

  Fly   527 ----PVIPNFDES-----LANVTK---ELASLWSSKS-VAELADSAEIKTT-----ISIHQLID- 572
                .|.|:.|::     ||..||   :.:.:.|.:| ..||.|....|..     |.|....|
Yeast   568 LSTADVKPDEDKTIYPVFLALKTKNGVDSSVVLSERSKTIELEDPTFFKVNSEQSGIYITSYTDE 632

  Fly   573 FLGKLIESKDIVDLNEGKINLLESTYNLKSSKNAEVRFRLNRLIIRARLIKRL---DEILEFANS 634
            ...||.:..|::.: |.::.|:.....|.:|........|| |:.:....|..   |:|:   ||
Yeast   633 RWAKLGQQADLLSV-EDRVGLVADVKTLSASGYTSTTNFLN-LVSKWNNEKSFVVWDQII---NS 692

  Fly   635 NFRMKFCRPIYRDLAGW---PEAKPAAIRNFVNVKDQMMAVCSH 675
            ...||         :.|   |:....|:.||..   |:::..:|
Yeast   693 ISSMK---------STWLFEPKETQDALDNFTK---QLISGMTH 724

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10602	NP_609916.5	Ribosomal_L13	15..>50	CDD:459856
		leuko_A4_hydro	79..681	CDD:274120	170/694 (24%)
APE2	NP_012765.3	M1_APN-Q_like	109..543	CDD:341064	124/482 (26%)
		ERAP1_C	614..928	CDD:463368	28/128 (22%)