Protein Alignment CG10602 and LNPEP

DIOPT Version :10

• Sequence 1: NP_609916.5
• Gene: CG10602 / 35146
• FlyBaseID: FBgn0032721
• Length: 684
• Species: Drosophila melanogaster
• Sequence 2: XP_054208557.1
• Gene: LNPEP / 4012
• HGNCID: 6656
• Length: 1097
• Species: Homo sapiens
• Alignment Length: 676
• Identity: 163/676 - (24%)
• Similarity: 264/676 - (39%)
• Gaps: 163/676 - (24%)

  Fly    35 KTHLLGLQKPIYHPMISTRGLCTSHKLLPIYQVQKRNMGRLGVVDPSSYSQPDLITTEHSALNWK 99
            |...:||.:|          ..|:.||.|..|:      ||          |..:......|:..
Human   216 KNQSIGLIQP----------FATNGKLFPWAQI------RL----------PTAVVPLRYELSLH 254

  Fly   100 IDFAATKIQGSVLHRFKVLTANLDKILLDVRDINVTNATLLAGGSELPINFFISDAVDDI----- 159
            .:..:...:|||....:.|....: |:|.....|::..|.::..|.       .:...:|
Human   255 PNLTSMTFRGSVTISVQALQVTWN-IILHSTGHNISRVTFMSAVSS-------QEKQAEILEYAY 311

  Fly   160 -GQKLTLELPSGTAKG-SLNVRIDYET--SSSASGLQWLNPTQTLGKEHPYMFSQCQAIHARSVI 220
             || :.:..|.....| :..::|:|..  |||..|....:.|....::..:..:|.:.:.|||..
Human   312 HGQ-IAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAARSAF 375

  Fly   221 PCQDTPAVKFTYDATVEHPSELTALMSALIDKK-----EPG--KTLFKQEVPIPAYLVAIAIGKL 278
            ||.|.||.|.|:...:....:.|||.:  :.||     :.|  :..|.:.|.:..||||..:|::
Human   376 PCFDEPAFKATFIIKIIRDEQYTALSN--MPKKSSVVLDDGLVQDEFSESVKMSTYLVAFIVGEM 438

  Fly   279 VSRPLGENSSVWAEEAIVDACAEEFSETATMLKTATELCG--------PYVWKQYDLLVMPPSFP 335
            .:.....|.::    ..:.|..|:..:....|:|..:|..        .|..|:.||:.: |.|.
Human   439 KNLSQDVNGTL----VSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQYPLKKLDLVAI-PDFE 498

  Fly   336 FGGMEN-PCLTFVTPTLL--AGDKSLAD------VVAHEIAHSWTGNLVTNKNFEHFWLNEGFTV 391
            .|.||| ..|||...|||  :...|:||      ::|||:||.|.|||||.|.:...||||||..
Human   499 AGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWWNDLWLNEGFAT 563

  Fly   392 FVE----SKIVGRMQGAKELDFKMLSNLTDLQEC-----IRTQLNKTPELTKLVVDLSNCGPDDA 447
            |:|    .||           ||.||:..|..:.     .:..||.:..::..|......  ::.
Human   564 FMEYFSLEKI-----------FKELSSYEDFLDARFKTMKKDSLNSSHPISSSVQSSEQI--EEM 615

  Fly   448 FSSVPYIKGSTFLRYL-----EDLFGGPTVFEPFLRDYLKKYAYKSIETKDFQSALYDYF----- 502
            |.|:.|.|||:.|..|     ||:|....|.      ||..::|.||::.|    |:|.|
Human   616 FDSLSYFKGSSLLLMLKTYLSEDVFQHAVVL------YLHNHSYASIQSDD----LWDSFNEVTN 670

  Fly   503 --IDTDKKDKLSAVDWDLWLKSEGMPPVIPNFDESLANVTKELASLWSSKSVAELADSAEIK--- 562
              :|..:..|       .|...:|.|         |..|.|:...|:..:....|....||:
Human   671 QTLDVKRMMK-------TWTLQKGFP---------LVTVQKKGKELFIQQERFFLNMKPEIQPSD 719

  Fly   563 TTISIHQLIDFLGK-----LIESKDIVDLNEGKINLLESTYNLKSSKNAE--------------- 607
            |:...|..:.::.:     ..:|..::|...|.|||.|....:|.:.|..
Human   720 TSYLWHIPLSYVTEGRNYSKYQSVSLLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEAL 784

  Fly   608 -VRFRLNRLII----RARLIKRLDEI 628
             .:.::|..::    ||.||..:.|:
Human   785 IHQLKINPYVLSDKDRANLINNIFEL 810

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10602	NP_609916.5	Ribosomal_L13	15..>50	CDD:459856	4/14 (29%)
		leuko_A4_hydro	79..681	CDD:274120	152/632 (24%)
LNPEP	XP_054208557.1	M1_APN-Q_like	247..684	CDD:341064	125/482 (26%)
		ERAP1_C	761..1081	CDD:463368	8/50 (16%)