Protein Alignment CG10602 and TRHDE

DIOPT Version :10

• Sequence 1: NP_609916.5
• Gene: CG10602 / 35146
• FlyBaseID: FBgn0032721
• Length: 684
• Species: Drosophila melanogaster
• Sequence 2: NP_037513.2
• Gene: TRHDE / 29953
• HGNCID: 30748
• Length: 1069
• Species: Homo sapiens
• Alignment Length: 711
• Identity: 153/711 - (21%)
• Similarity: 263/711 - (36%)
• Gaps: 160/711 - (22%)

  Fly    76 GVVDPSSYS-QPDLITTEHSALNWKIDFAATKIQGSV--LHRFKVLTANLD------KILLDVRD 131
            ||..|.:.| ||   .:|.....|: .:...::.|.:  ||...:|||.::      ::.:::..
Human   158 GVASPGTTSAQP---PSEEEREPWE-PWTQLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIAC 218

  Fly   132 INVTNATLL----------------AGGSELPINFFISDAVDDIGQKLTLELPSGTAKGSLNVRI 180
            .|.|...:|                |.|:.....||:......:...|...|   .|:.:.|::|
Human   219 RNATRYVVLHASRVAVEKVQLAEDRAFGAVPVAGFFLYPQTQVLVVVLNRTL---DAQRNYNLKI 280

  Fly   181 DYETSSSASGLQWLNPTQTLGKEHPYM-FSQCQAIHARSVIPCQDTPAVKFTYDATVEHPSELTA 244
            .|........|.:...:..|..|..:: .:|....|||...||.|.|..|.|:..:::|.:...:
Human   281 IYNALIENELLGFFRSSYVLHGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLS 345

  Fly   245 LMSALIDK---KEPGKTL--FKQEVPIPAYLVAIAIGKLVSRPLGENSSVWAE-EAIVDACAEEF 303
            |.:..::.   :|.|...  |.|...:..|.:|.||.....|.....|.|... .|..||.....
Human   346 LSNMPVETSVFEEDGWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGS 410

  Fly   304 SETAT-MLKTATELCG-----PYVWKQYDLLVMPPSFPFGGMENPCLTFVTPTLLAGDKSLAD-- 360
            .:.|. :.|...|...     ||...:.|||.: |..|:..|||..|:......:..|.|::.
Human   411 GDYALHITKRLIEFYEDYFKVPYSLPKLDLLAV-PKHPYAAMENWGLSIFVEQRILLDPSVSSIS 474

  Fly   361 -------VVAHEIAHSWTGNLVTNKNFEHFWLNEGFTVFVESKIVGRMQGAKELDFKMLSNLTDL 418
                   |:.|||.|.|.|:|||...:|..||.|||..:.|  .||........:.:....|||:
Human   475 YLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFE--FVGTDYLYPGWNMEKQRFLTDV 537

  Fly   419 --QECIRTQLNKTPELTKLVVDLSNCGPDDAFSSVPYIKGSTFLRYLEDLFGGPTVFEPFLRDYL 481
              :..:...|..:..:::.|:..::.  |..|..:.|.||:..:|.|.: |.|.:||:..|:|||
Human   538 LHEVMLLDGLASSHPVSQEVLQATDI--DRVFDWIAYKKGAALIRMLAN-FMGHSVFQRGLQDYL 599

  Fly   482 KKYAYKSIETKDFQSALYDYFIDTDKKDKLSAVDWDLWLKSEGMPPVI---------------PN 531
            ..:.|.:....|..:.|.:......|...:..| .|.|....|.|.:.               .:
Human   600 TIHKYGNAARNDLWNTLSEALKRNGKYVNIQEV-MDQWTLQMGYPVITILGNTTAENRIIITQQH 663

  Fly   532 FDESLANVTKEL-----ASLW--------------SSKSVAELADSAEIKTTISIHQLIDFLGK- 576
            |...::..||.|     :.||              ||:::..:::.:|       |..|.:|.|
Human   664 FIYDISAKTKALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSE-------HHRITYLDKG 721

  Fly   577 ----------------------------LIESKDIVDLNEGKINLLESTYNLKSSKNAEVRFRLN 613
                                        ||.:.:::.:: .:..|::..::|..:........|.
Human   722 SWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVS-NRAGLIDDAFSLARAGYLPQNIPLE 785

  Fly   614 RLIIR--------------ARLIKRLDEILE-FANSNFRMKFCRPIYRDLA------GWPE 653
              |||              :|.:..||::|: ..|.|.   |...|.:.:|      |||:
Human   786 --IIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNI---FNEYILKQVATTYIKLGWPK 841

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10602	NP_609916.5	Ribosomal_L13	15..>50	CDD:459856
		leuko_A4_hydro	79..681	CDD:274120	151/708 (21%)
TRHDE	NP_037513.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..46
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	117..179		7/23 (30%)
		M1_APN-Q_like	193..638	CDD:341064	109/454 (24%)
		ERAP1_C	723..1047	CDD:463368	20/125 (16%)