Protein Alignment CG10602 and ANPEP

DIOPT Version :10

• Sequence 1: NP_609916.5
• Gene: CG10602 / 35146
• FlyBaseID: FBgn0032721
• Length: 684
• Species: Drosophila melanogaster
• Sequence 2: NP_001141.2
• Gene: ANPEP / 290
• HGNCID: 500
• Length: 967
• Species: Homo sapiens
• Alignment Length: 616
• Identity: 138/616 - (22%)
• Similarity: 222/616 - (36%)
• Gaps: 189/616 - (30%)

  Fly    38 LLGLQKPIYHPMISTRGLCTSHKLLPIYQVQKRNMGRLGVVDPSSYSQPDLITTEHSALNWKIDF 102
            :||:       ::....:||...|..:|..:|         :.::.|.|...||..::.......
Human    13 ILGI-------LLGVAAVCTIIALSVVYSQEK---------NKNANSSPVASTTPSASATTNPAS 61

  Fly   103 AATKIQGSVLHRFKV----------------LTAN--------------------LDKILLDVRD 131
            |.|..|....:|:::                ||.|                    .|.|::..:.
Human    62 ATTLDQSKAWNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVIIIHSKK 126

  Fly   132 INVT----NATLL--AGGSELPINFFISDAVDDIGQKLTLELPSGT------AKGSLNVRIDYET 184
            :|.|    :..:|  .|||:.|          ||.:   .||...|      .||||.....||.
Human   127 LNYTLSQGHRVVLRGVGGSQPP----------DIDK---TELVEPTEYLVVHLKGSLVKDSQYEM 178

  Fly   185 SSSASGLQWLNPTQTLGKE------HPYM---------FSQCQAIHARSVIPCQDTPAVKFTYDA 234
            .|...|        .|..:      ..||         .:|.||..||...||.|.||:|..::.
Human   179 DSEFEG--------ELADDLAGFYRSEYMEGNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNI 235

  Fly   235 TVEHPSELTALMSALIDKKEPGKTL----------FKQEVPIPAYLVAIAIG------KLVSRPL 283
            |:.||.:||||.:.|  .|.|...|          |.....:..||:|..:.      |..|.
Human   236 TLIHPKDLTALSNML--PKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASN-- 296

  Fly   284 GENSSVWAEEAIVDACAEEFSETAT---MLKTATELCGPYVWKQYDLLVMPPSFPFGGMEN-PCL 344
            |....:||..:.:.|...:::...|   :...|.....||...:.|.:.: |.|..|.||| ..:
Human   297 GVLIRIWARPSAIAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGL-PDFNAGAMENWGLV 360

  Fly   345 TFVTPTLL--------AGDKSLADVVAHEIAHSWTGNLVTNKNFEHFWLNEGFTVFVESKIVGRM 401
            |:...:||        :..:.:..|:|||:||.|.|||||.:.:...||||||..:||  .:|..
Human   361 TYRENSLLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVE--YLGAD 423

  Fly   402 QGAKELDFKMLSNLTDLQECI--------------RTQLNKTPELTKLVVDLSNCGPDDAFSSVP 452
            ......:.|.|..|.|:...:              .:::|...::::|            |.::.
Human   424 YAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISEL------------FDAIS 476

  Fly   453 YIKGSTFLRYLEDLFGGPTVFEPFLRDYLKKYAYKSIETKDFQSALYDYFIDTDKKDKLSAVDWD 517
            |.||::.||.|.. |....||:..|..||..:||        |:.:|                .:
Human   477 YSKGASVLRMLSS-FLSEDVFKQGLASYLHTFAY--------QNTIY----------------LN 516

  Fly   518 LWLKSEGMPPVIPNFDESLANVTKELASLWS 548
            ||   :.:...:.|....|....:::.:.|:
Human   517 LW---DHLQEAVNNRSIQLPTTVRDIMNRWT 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10602	NP_609916.5	Ribosomal_L13	15..>50	CDD:459856	2/11 (18%)
		leuko_A4_hydro	79..681	CDD:274120	131/575 (23%)
ANPEP	NP_001141.2	Cytosolic Ser/Thr-rich junction	33..68		8/43 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	40..62		4/21 (19%)
		Metalloprotease	69..967		124/544 (23%)
		M1_APN-Q_like	84..545	CDD:341064	123/529 (23%)
		Necessary and sufficient to mediate interaction with HCoV-229E. /evidence=ECO:0000269|PubMed:1350662, ECO:0000269|PubMed:8887485	288..295		1/6 (17%)
		ERAP1_C	619..946	CDD:463368