Protein Alignment CG10602 and Npepps

DIOPT Version :10

• Sequence 1: NP_609916.5
• Gene: CG10602 / 35146
• FlyBaseID: FBgn0032721
• Length: 684
• Species: Drosophila melanogaster
• Sequence 2: NP_032968.2
• Gene: Npepps / 19155
• MGIID: 1101358
• Length: 920
• Species: Mus musculus
• Alignment Length: 629
• Identity: 157/629 - (24%)
• Similarity: 262/629 - (41%)
• Gaps: 116/629 - (18%)

  Fly    38 LLGLQKPIYHPMI-----STRGLCTSHKLLPIYQVQKRNMGRL-GVVDPSSYS---QPDLITTEH 93
            |||...|   |::     |:|.....|.|......:||...|| ..|.|.:||   :|||:   .
Mouse    16 LLGPPPP---PLLLLLSRSSRRRRRLHSLGLAAMPEKRPFERLPAEVSPINYSLCLKPDLL---D 74

  Fly    94 SALNWKIDFAATKIQGSVLHRFKVLTANLDKILLDVRDINVTNATLLAGGSE----LPINFFISD 154
            .....|::.||...|.:            ::|:::..||::..|:....|.|    ...|:...|
Mouse    75 FTFEGKLEAAAQVRQAT------------NQIVMNCADIDIITASYAPEGDEEIHATGFNYQNED 127

  Fly   155 AVDDIGQKLTLELPSGTAKGSLNVRIDY--ETSSSASGLQWLNPTQTLGKEHPYMFSQCQAIHAR 217
                  :|:||..||....|:..::||:  |.:....|......|...|:......:|.:|..||
Mouse   128 ------EKVTLSFPSTLQTGTGTLKIDFVGELNDKMKGFYRSRYTTPAGEVRYAAVTQFEATDAR 186

  Fly   218 SVIPCQDTPAVKFTYDATVEHPSELTALMSA-LIDKKE-PG-----KTLFKQEVPIPAYLVAIAI 275
            ...||.|.||:|.|:|.::..|.:..||.:. :||:|. |.     :..|.:...:..||||..:
Mouse   187 RAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDDENLVEVKFARTPVMSTYLVAFVV 251

  Fly   276 GKL--------------VSRPLGENSSVWAEEAIVDACAEEFSETATMLKTATELCGPYVWKQYD 326
            |:.              |..|:|:     ||:.  ....|..::|....|....:  ||...:.|
Mouse   252 GEYDFVETRSKDGVCVRVYTPVGK-----AEQG--KFALEVAAKTLPFYKDYFNV--PYPLPKID 307

  Fly   327 LLVMPPSFPFGGMEN-PCLTFVTPTLLAGDKS--------LADVVAHEIAHSWTGNLVTNKNFEH 382
            |:.: ..|..|.||| ..:|:....||...|:        :|.||.||:||.|.|||||.:.:.|
Mouse   308 LIAI-ADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELAHQWFGNLVTMEWWTH 371

  Fly   383 FWLNEGFTVFVESKIVGRMQGAKELDFKMLS-NLTDLQECIRTQLNKTPELTKLVVDLSNCGP-- 444
            .||||||..::|...|.......::..:.:| :.|..|| :....|..|      :::|...|
Mouse   372 LWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQE-LDALDNSHP------IEVSVGHPSE 429

  Fly   445 -DDAFSSVPYIKGSTFLRYLEDLFGGPTVFEPFLRDYLKKYAYKSIETKDFQSALYDYFIDTDKK 508
             |:.|.::.|.||::.:|.|.|..|... |:..:..||.|:..|:..|:|...:|     ::...
Mouse   430 VDEIFDAISYSKGASVIRMLHDYIGDKD-FKKGMNMYLTKFQQKNAATEDLWESL-----ESASG 488

  Fly   509 DKLSAVDWDLWLKSEGMPPVIPNF----DESLANVTK-----------ELASLWS---SKSVAEL 555
            ..::|| .:.|.|..|.|.:....    |:.:..:::           |....|.   :.|.:|.
Mouse   489 KPIAAV-MNTWTKQMGFPLIYVEAEQVEDDRVLKLSQKKFCASGPYGGEDCPQWMVPITISTSED 552

  Fly   556 ADSAEIKTTISIHQLIDFLGKLIESKDIVDLNEGKINLLESTYN 599
            .:.|::|..:...::...| |.::....|.||.|.:....:.|:
Mouse   553 PNQAKLKILMDKPEMSVVL-KNVKPDQWVKLNLGTVGFYRTQYS 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10602	NP_609916.5	Ribosomal_L13	15..>50	CDD:459856	5/11 (45%)
		leuko_A4_hydro	79..681	CDD:274120	143/582 (25%)
Npepps	NP_032968.2	M1_APN-Q_like	62..500	CDD:341064	125/482 (26%)
		ERAP1_C	579..892	CDD:463368	5/17 (29%)
		Nuclear localization signal. /evidence=ECO:0000255	727..731