DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10600 and Rsbn1

DIOPT Version :9

Sequence 1:	NP_001137839.1	Gene:	CG10600 / 35142	FlyBaseID:	FBgn0032717	Length:	1406	Species:	Drosophila melanogaster
Sequence 2:	NP_001343485.1	Gene:	Rsbn1 / 229675	MGIID:	2444993	Length:	795	Species:	Mus musculus

Alignment Length:	960	Identity:	294/960 - (30%)
Similarity:	420/960 - (43%)	Gaps:	293/960 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 AVGASKQ-----RETPEKGVNKASAVENNNANARGNASPTTTSAQ----------REATTTITPV 84
            ||.|.::     :|.|..||:.........|::.|:.......:|          |.:.....|:
Mouse    60 AVAAQEEPDKEGKEKPHVGVSPRGVKRQRRASSGGSQEKRGRPSQDPPLAPPHRRRRSRQHPGPL 124

  Fly    85 EPTAAATTTNGNTLPTQQQQQLQSGDGNANNPTTNARIMLAAAEEEQAVASSVATTAGAPTAATT 149
            .||.||.|..|...|                       :|.......::|.:..|.| ||..|..
Mouse   125 PPTNAAPTVPGPVEP-----------------------LLLPPPPPPSLAPAGPTVA-APLPAPG 165

  Fly   150 TATTTALADTTKTSTSTDEKTGKVKRNSQNTNPMSTNVICTPTHSPTPPTEERNHKRKKRDRERD 214
            |:.....:..|.::..                         |.|        :.||.:
Mouse   166 TSALFTFSPLTVSAAG-------------------------PKH--------KGHKER------- 190

  Fly   215 EDKNRRSNNHNSSSKDRDKDRDRD-KERDKERDRERE------RDRNRESSSKSSKEAEHK---- 268
                .:.::|..|..|.......| |.:||:.:.||.      :...||::.::.|.....
Mouse   191 ----HKHHHHRGSDGDPGACVPGDLKHKDKQENGERSGGVPLIKAPKRETADENGKTQRADDFVL 251

  Fly   269 SSSSRSKEKYHRSDRDREREKERDREKIPSSSSSSSSHSNRRRSSDSSRSSQNSSFKSKDPGADP 333
            ....:.|:|.||.|....|.|..::|
Mouse   252 KKIKKKKKKKHREDMRGRRLKMYNKE--------------------------------------- 277

  Fly   334 VLPQAVVAALEKQIKVEEVIKKEPVETKQEVDTEPTPVLSNLIKTEAEIKTESTEKPNKPLVNGE 398
              .|.|.|.|.:       |.||                   |.|:.::.:.|.       ||.|
Mouse   278 --VQTVCAGLTR-------ISKE-------------------ILTQGQLNSTSG-------VNKE 307

  Fly   399 AIAKTRDEVSRQLNFGDKVSNSKLMPSPAPKSSSGSNSTASNHSSSQSSSSRKSYLSSSSSSSSS 463
            :....:||...:||.|       :.....|:   |..:..:.|   |..|.|:::|.:.:..|:.
Mouse   308 SFRYLKDEQLCRLNLG-------MQEYRVPQ---GVQTPFTTH---QEHSIRRNFLKTGTKFSNF 359

  Fly   464 NHHKSSSSSSSRHSSSTSRECSKCYKRSKIRRTSVGVQCLQHAPATGPWQTVQSLPPRPNRKPPA 528
            .|.:..|
Mouse   360 IHEEHQS---------------------------------------------------------- 366

  Fly   529 GLENLKYGCYFQVEQYPNGGASIVHLYQHEIDALSPDEMEELVDEFFEVCFAEDEQGYAHHVMGI 593
                             ||||.::|.|..|:..|||.|||...:||..:.|:|:|:..|::.:.|
Mouse   367 -----------------NGGALVLHAYMDELSFLSPMEMERFSEEFLALTFSENEKNAAYYALAI 414

  Fly   594 VHDAARYLPDLLEHMAENYSTLTVKAGVLGRNSDIETCTMSQYNEQVVRNYCQGTFRYGPLHQIS 658
            ||.||.||||.|::.|.|:....||..:||: .||||.|:|.::.||.|.||.||:|.||:.|||
Mouse   415 VHGAAAYLPDFLDYFAFNFPNTPVKMEILGK-KDIETTTISNFHTQVNRTYCCGTYRAGPMRQIS 478

  Fly   659 LVGKVHEEVGGYFPDLLGRIEMNPFLRKTMPWACNSILQTDPR-QSNDGPILWIRAGEQLVPTAE 722
            |||.|.||||.|||:.|..:|.:|||:.|:||...|.||...| ||:||||:|:|.|||::|||:
Mouse   479 LVGAVDEEVGDYFPEFLDMLEESPFLKMTLPWGTLSSLQLQCRSQSDDGPIMWVRPGEQMIPTAD 543

  Fly   723 LNSKTPLKRQRTRINELRNLQYLPRLSEARETMIEDRTKAHADHVGHGHERITTAAVGILKAVHC 787
            : .|:|.||:|: :||::|||||||.||.||.:.||||:|||||||.|.:..:|||||:||||..
Mouse   544 M-PKSPFKRRRS-MNEIKNLQYLPRTSEPREVLFEDRTRAHADHVGQGFDWQSTAAVGVLKAVQF 606

  Fly   788 GQTYSQNRITKDVVAFAAQDFNTMVEMLQLDLHEPPISQCVQWIEDAKLNQLRREGVRYARIQLC 852
            |:...|.||||||:.|.|:||..:|:.|||||||||:||||||:::|||||:||||:||||||||
Mouse   607 GEWSDQPRITKDVICFHAEDFTDVVQRLQLDLHEPPVSQCVQWVDEAKLNQMRREGIRYARIQLC 671

  Fly   853 DNDIYFLPRNIIHQFRTVTAVTSVAWHLRLRQYYPGQEVINEKNNPVLAETPHYKEKQTILPNPI 917
            ||||||:|||:||||:||:||.|:|||:||:||:|            :.||....|..
Mouse   672 DNDIYFIPRNVIHQFKTVSAVCSLAWHIRLKQYHP------------VVETAQNTESN------- 717

  Fly   918 SHDECGKKTPSKRAHDGRTKKKLIDLDGKERRSSESSIDEHPAAGSSSPS 967
            |:.:||.:..|:..              :.:..||....|.....::|||
Mouse   718 SNMDCGLEVDSQCV--------------RIKTESEERCTEMQLLTTASPS 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	Identity
CG10600	NP_001137839.1	None
Rsbn1	NP_001343485.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	64..158	19/116 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..248	16/113 (14%)
		Nuclear localization signal. /evidence=ECO:0000255	252..263	2/10 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	774..795
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848633
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004037
OrthoInspector	1	1.000	-	-		otm42888
orthoMCL	1	0.900	-	-		OOG6_105705
Panther	1	1.100	-	-	LDO	PTHR13354
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4253
SonicParanoid	1	1.000	-	-		X2780
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.830