DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10600 and dpy-21

DIOPT Version :9

Sequence 1:	NP_001137839.1	Gene:	CG10600 / 35142	FlyBaseID:	FBgn0032717	Length:	1406	Species:	Drosophila melanogaster
Sequence 2:	NP_001024266.1	Gene:	dpy-21 / 180176	WormBaseID:	WBGene00001080	Length:	1641	Species:	Caenorhabditis elegans

Alignment Length:	1036	Identity:	260/1036 - (25%)
Similarity:	401/1036 - (38%)	Gaps:	277/1036 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 ENNNANARGNASPTTTSAQREATTTITPVEPTAAATTTNGNTLPTQ----QQQQLQSGDGNANNP 116
            :|..|:..|...|....|..|....:.||.........:....||:    :.:.::.      .|
Worm   686 KNKTASMVGPPEPKELPAVVEVEAIVEPVVEDQPEPVVSEELKPTEPEPVEPEPMEV------EP 744

  Fly   117 TTNARIMLAAAEE------------EQAVASSVATTA------------GAPTAATTTATTTA-- 155
            .....::....||            |.:.:||:...|            ..|.....||...|
Worm   745 VVAKEVVEEVVEEVVETQEPWVPLSECSRSSSLELLAELPPPPRASEPPPPPPPPVATAPVPASM 809

  Fly   156 ----------LADTTKTSTSTDEKTGKVKRNSQNT--------NPMST---------NVICTPTH 193
                      :.:.|.|||...||..|:|:....|        .|..|         ....:|:.
Worm   810 EEDEIIDIETIDEITSTSTKKPEKVEKIKKAPVVTKAALKMVGRPKKTPGRRRKKDRGASPSPSP 874

  Fly   194 SPTPPTEERNH----KRKKRDRERDE------------------------DKNRRSNNHNSSSKD 230
            ||.||.|....    .|||:..|:.:                        .|.:....|:|
Worm   875 SPPPPPETTLTPIVLPRKKQRIEKKKLTPPPPQQAPVTSHTPPPVEQLMSRKKQIMMEHSS---- 935

  Fly   231 RDKDRDRDKERDKERDRERERDRNRESSSKSSKEAEHKSSSSRSKEKYHRSDRDREREKERDREK 295
              .|..:.|..:.|...:|   |..|:::|::...|.|               |.:.|:..:||.
Worm   936 --LDHIQFKLIEIELAAKR---RKAEAAAKAAAAVEQK---------------DEKAEEVENRET 980

  Fly   296 IPSSSS---SSSSHSNRRRSSDSSRSSQNSSFKSKDPGADPVLPQAVVAALEKQI---KVEEVIK 354
            .|..|:   |||.|:......|.....:.|:.: |....:....:.|:.|.::.:   |:||.
Worm   981 PPGPSTSMRSSSLHTPNTSEEDEVIFVEPSTLE-KPERRNGTTEERVMTADQRAMFDAKIEEA-- 1042

  Fly   355 KEPVETKQEVDTEPTPVLSNLIKTEAEIKTESTEKPNKPLVNGEAIAKTRDEVSRQLNFGDKVSN 419
                 .:..:.|....|:|.|    ..:|::::::.:..:...|.:..:.|:.:.        :|
Worm  1043 -----RRSRMSTRDCSVVSTL----GPVKSKASQRLHDIIEGKEELEDSMDDPTN--------NN 1090

  Fly   420 SKLMPSPAPKSSSGSNSTASNHSSSQSSSSRKSYLSSSSSSSSSNHHKSSSSSSSRHSSSTSREC 484
            ..|.....|..|..:.|.:|||.|           ..:..|.|..||.:..:.....::...|
Worm  1091 GTLAGILYPMRSERAESVSSNHRS-----------EGAGGSMSLKHHLARKNELKEEANVARR-- 1142

  Fly   485 SKCYKRSKIRRTSVGVQCLQHAPATGPWQTVQSL-----PPRPNRKPPAGL-------------- 530
            |:..|....|:..:||      |.|...::...|     ..|.|.|....|
Worm  1143 SEILKAVVKRQREIGV------PTTLMSKSAIELVEEDEKERKNHKNNKTLSHPDYVRSKNEAEK 1201

  Fly   531 --------------ENLK--------------YGCYFQVEQYPNGGASIV-----HLYQHEIDAL 562
                          .|||              :..:.::.::|||.|:|:     .:.||    |
Worm  1202 AEFHGKGGTMRITNRNLKMLTRQFDLPKMSSRFRKFVRIRRHPNGMATIISCDYNQIKQH----L 1262

  Fly   563 SPDEMEELVDEFFEVCFAEDEQGYAHHVMGIVHDAARYLPDLLEHMAENYSTLTVKAGVLGRNSD 627
            .|:||:....:|..:.|||: .|.....:|::.:||..|.|..|.:|:|.....||.|.|.....
Worm  1263 GPNEMKHFERQFVRLGFAEN-NGVPLFAIGVMENAAEALHDQFEWLAKNSPNTQVKVGSLTNKQF 1326

  Fly   628 IETCTMSQYNEQVVRNYCQGTFRYGPLHQISLVGKVHEEVGGYFPDLLGRIEMNPFLRKTMPWAC 692
            |||..|.:|.|..:.....||||:|||..:|:||..:||.||.|.::|..:...|||...|||..
Worm  1327 IETMPMKKYYESAMETLDMGTFRFGPLMSLSMVGTKNEEAGGNFKEMLDALNAAPFLGPIMPWGD 1391

  Fly   693 NSILQ-TDPRQSNDGPILWIRAGEQLVPTAELNSKT-PLKRQRTRINELRNLQYLPRLSEARETM 755
            .|.:| .....|:||||.|:|.|||:|||...|..| |.....||.|            :.|||.
Worm  1392 FSEVQGIKEDTSDDGPIFWVRPGEQMVPTDGKNRSTEPRHPLATRGN------------DRRETA 1444

  Fly   756 IEDRTKAHADHVGHGHER--------------------------------ITTAAVGILKAVH-- 786
            ..|||.||||.|....|.                                .:|||||:|:.:.
Worm  1445 FNDRTNAHADQVRESTEDDPTTTTTTTTTTSSSSSSSKSKKSAKSDPTFVKSTAAVGVLQGIRNP 1509

  Fly   787 ----CGQTYSQNR-ITKDVVAFAAQDFNTMVEMLQLDLHEPPISQCVQWIEDAKLNQLRREGVRY 846
                ..:.|...| ..|:|:.|.|.|.:.:...|.:||:|||:|||.:|::||.||.:||||:||
Worm  1510 DANDDDEYYEDERKAVKEVIVFDAHDLHKVAHHLAMDLYEPPVSQCHRWVDDAILNTMRREGIRY 1574

  Fly   847 ARIQLCDNDIYFLPRNIIHQFRTVTAVTSVAWHLRLRQYYPGQEVINEKNNPVLAETPHYK 907
            |:::|.:||:||||||:|||||||:|.:|||||:|||.||       :.:.|.....|.::
Worm  1575 AKLELHENDMYFLPRNVIHQFRTVSACSSVAWHVRLRHYY-------DVDQPASLSDPQFE 1628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
CG10600	NP_001137839.1	None
dpy-21	NP_001024266.1	Bud13	395..>440	CDD:313032
dpy-21	NP_001024266.1	FtsK	<433..>666	CDD:332908
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165949
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004037
OrthoInspector	1	1.000	-	-		oto19647
orthoMCL	1	0.900	-	-		OOG6_105705
Panther	1	1.100	-	-	LDO	PTHR13354
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4253
SonicParanoid	1	1.000	-	-		X2780
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.960