DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17597 and SCP2

DIOPT Version :9

Sequence 1:	NP_001286066.1	Gene:	CG17597 / 35140	FlyBaseID:	FBgn0032715	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_002970.2	Gene:	SCP2 / 6342	HGNCID:	10606	Length:	547	Species:	Homo sapiens

Alignment Length:	405	Identity:	258/405 - (63%)
Similarity:	321/405 - (79%)	Gaps:	2/405 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 TKTRVYVIGVGMTKFEKPGRRADACYPDFAKEAITKALQDAGIKFEEVQQAVAGYVYGDSTCGQR 66
            |..||:|:|||||||.|||......|||.|:||..|||.||.|.:..|.||..|||:||||||||
Human    10 TLRRVFVVGVGMTKFVKPGAENSRDYPDLAEEAGKKALADAQIPYSAVDQACVGYVFGDSTCGQR 74

  Fly    67 AIY-EVGMTGIPVYNVNNNCSTGSSALYLAKQIVESGNSECVLALGFEKMERGSLSAKYFDRANP 130
            ||| .:||||||:.||||||:|||:||::|:|:::.|.:|||||||||||.:|||..|:.||..|
Human    75 AIYHSLGMTGIPIINVNNNCATGSTALFMARQLIQGGVAECVLALGFEKMSKGSLGIKFSDRTIP 139

  Fly   131 MERHITEMSELTEIGAGPMAAQIFGNAGKEHMKKYGTKPEHFGKIAWKNHKHSVNNPYSQFRDEY 195
            .::|:..:.....:.|.|:|.|:||.||||||:|||||.|||.||.|||||||||||||||:|||
Human   140 TDKHVDLLINKYGLSAHPVAPQMFGYAGKEHMEKYGTKIEHFAKIGWKNHKHSVNNPYSQFQDEY 204

  Fly   196 TLEQIMKSPQVVEGVLTKLQCCPTSDGSGAAILASEAFVRRHGLEKQAVEIVGMEMASDPASTFA 260
            :|:::|.|.:|.: .||.|||||||||:.||||||||||:::||:.:||||:..||.:|..|:|.
Human   205 SLDEVMASKEVFD-FLTILQCCPTSDGAAAAILASEAFVQKYGLQSKAVEILAQEMMTDLPSSFE 268

  Fly   261 DKSLMKIAGTDMTRLATERLFAKSGYKPQDVQVVELHDCFSANELITYEALGLCGEGKAGEFIDA 325
            :||::|:.|.||::.|..:.:.|||..|.|:.|:|||||||.|||:||||||||.||:....:|.
Human   269 EKSIIKMVGFDMSKEAARKCYEKSGLTPNDIDVIELHDCFSTNELLTYEALGLCPEGQGATLVDR 333

  Fly   326 GDNTYGGKFVVNPSGGLISKGHPLGATGLAQCAELCWQLRGLAEKRQVPNAQLALQHNLGLGGAV 390
            ||||||||:|:||||||||||||||||||||||||||||||.|.|||||.|::|||||||:||||
Human   334 GDNTYGGKWVINPSGGLISKGHPLGATGLAQCAELCWQLRGEAGKRQVPGAKVALQHNLGIGGAV 398

  Fly   391 VVALYRLGFPGAAKA 405
            ||.||::|||.||.:
Human   399 VVTLYKMGFPEAASS 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17597	NP_001286066.1	PRK08256	5..396	CDD:181327	251/391 (64%)
CG17597	NP_001286066.1	SCP-x_thiolase	9..395	CDD:238425	247/386 (64%)
SCP2	NP_002970.2	PRK08256	12..404	CDD:181327	251/392 (64%)
		SCP2	452..538	CDD:307934
		Microbody targeting signal. /evidence=ECO:0000255	545..547
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	254	1.000	Domainoid score	I2065
eggNOG	1	0.900	-	-		E1_KOG1406
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	648	1.000	Inparanoid score	I801
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61490
OrthoDB	1	1.010	-	-		D185465at33208
OrthoFinder	1	1.000	-	-		FOG0006286
OrthoInspector	1	1.000	-	-		otm41049
orthoMCL	1	0.900	-	-		OOG6_101329
Panther	1	1.100	-	-	O	PTHR24314
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4572
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.840