DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17597 and daf-22

DIOPT Version :9

Sequence 1:	NP_001286066.1	Gene:	CG17597 / 35140	FlyBaseID:	FBgn0032715	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_496639.1	Gene:	daf-22 / 174881	WormBaseID:	WBGene00013284	Length:	412	Species:	Caenorhabditis elegans

Alignment Length:	410	Identity:	230/410 - (56%)
Similarity:	310/410 - (75%)	Gaps:	5/410 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 TKTRVYVIGVGMTKFEKPGRRADACYPDFAKEAITKALQDAGIKFEEVQQAVAGYVYGDSTCGQR 66
            ||.:||::|||||||.|||......|||..|||:|.||.|..:|:.::|||..||::|.:.||||
Worm     4 TKPKVYIVGVGMTKFCKPGSVPGWDYPDMVKEAVTTALDDCKMKYSDIQQATVGYLFGGTCCGQR 68

  Fly    67 AIYEVGMTGIPVYNVNNNCSTGSSALYLAKQIVESGNSECVLALGFEKMERGS---LSAKYFDRA 128
            |:||||:||||::||||.|::|||.|:|.|||:|||||:.||..|||:|..||   |:|...|||
Worm    69 ALYEVGLTGIPIFNVNNACASGSSGLFLGKQIIESGNSDVVLCAGFERMAPGSLENLAAPIDDRA 133

  Fly   129 NPMERHITEMSELTEIGAGPMAAQIFGNAGKEHMKKYGTKPEHFGKIAWKNHKHSVNNPYSQFRD 193
            ..:::||:.|||...:...||.||:||||.||||:|||:|.||:.|||:|||.|||:||.|||..
Worm   134 LSVDKHISVMSETYGLEPAPMTAQMFGNAAKEHMEKYGSKREHYAKIAYKNHLHSVHNPKSQFTK 198

  Fly   194 EYTLEQIMKSPQVVEGVLTKLQCCPTSDGSGAAILASEAFVRRH-GLEKQAVEIVGMEMASDPAS 257
            |::|:|::.:.::.: .:..|:|.|||||:.||:|.||.|:.:: .|:.|||||||:::.:|..|
Worm   199 EFSLDQVINARKIYD-FMGLLECSPTSDGAAAAVLVSEKFLEKNPRLKAQAVEIVGLKLGTDEPS 262

  Fly   258 TFADKSLMKIAGTDMTRLATERLFAKSGYKPQDVQVVELHDCFSANELITYEALGLCGEGKAGEF 322
            .||:.|.:|:.|.||.:...::|:|::...|.||||:||||||:.||||||||:|||..|:....
Worm   263 VFAENSNIKMIGFDMIQKLAKQLWAETKLTPNDVQVIELHDCFAPNELITYEAIGLCPVGQGHHI 327

  Fly   323 IDAGDNTYGGKFVVNPSGGLISKGHPLGATGLAQCAELCWQLRGLAEKRQVPNAQLALQHNLGLG 387
            :|..|||||||:|:||||||||||||:||||:||..||..||||...||||||.::|:|||:|:|
Worm   328 VDRNDNTYGGKWVINPSGGLISKGHPIGATGVAQAVELSNQLRGKCGKRQVPNCKVAMQHNIGIG 392

  Fly   388 GAVVVALYRLGFPGAAKAKL 407
            ||.||.||||||||||::|:
Worm   393 GAGVVGLYRLGFPGAAQSKI 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17597	NP_001286066.1	PRK08256	5..396	CDD:181327	218/394 (55%)
CG17597	NP_001286066.1	SCP-x_thiolase	9..395	CDD:238425	215/389 (55%)
daf-22	NP_496639.1	PRK08256	7..388	CDD:181327	209/381 (55%)
daf-22	NP_496639.1	SCP-x_thiolase	11..388	CDD:238425	207/377 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159101
Domainoid	1	1.000	232	1.000	Domainoid score	I1366
eggNOG	1	0.900	-	-		E1_KOG1406
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	473	1.000	Inparanoid score	I829
Isobase	1	0.950	-	0	Normalized mean entropy	S2522
OMA	1	1.010	-	-		QHG61490
OrthoDB	1	1.010	-	-		D185465at33208
OrthoFinder	1	1.000	-	-		FOG0006286
OrthoInspector	1	1.000	-	-		otm14811
orthoMCL	1	0.900	-	-		OOG6_101329
Panther	1	1.100	-	-	O	PTHR24314
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3196
SonicParanoid	1	1.000	-	-		X4572
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.790