DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36E1 and Ugt1a6a

DIOPT Version :9

Sequence 1:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_659545.2	Gene:	Ugt1a6a / 94284	MGIID:	2137698	Length:	531	Species:	Mus musculus

Alignment Length:	537	Identity:	141/537 - (26%)
Similarity:	239/537 - (44%)	Gaps:	83/537 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 CLL--------ALLSLVAFSDSLRILG----LFPHPAISHFKFFHPIMRGLAEAGHSVDVISP-- 59
            |||        ..|.||.::.   :||    :.|... ||:.....|:..|:|.||.:.|:.|
Mouse     3 CLLPAAQTLPAGFLFLVLWAS---VLGDKLLVVPQDG-SHWLSMKEIVEHLSERGHDIMVLVPEV 63

  Fly    60 ------------------FEDKDPPNGYK----DHLLPPSTLTDTISLEDFERPYSFLFHYVEFF 102
                              :..::....::    :|.||.::|...:      |.|......|:.|
Mouse    64 NLLLGESKYYRRKIFSVTYSLEELQTRFRTFGNNHFLPGASLMGPL------REYRNNMIVVDMF 122

  Fly   103 ILHKMGREDCNTTLHSRALTEILKNPPGYYDVILLEQFNTDCAMSVAHVFQAPVIGMSSCAL--- 164
            .      .:|.:.|...|....|:.  ..:|.:.     ||.||... |..|..:.:.|..|
Mouse   123 F------SNCQSLLKDSATLSFLRE--NKFDALF-----TDPAMPCG-VILAEYLNLPSVYLFRG 173

  Fly   165 MPWHYERF--GAPLIPSYISALFQGQSQEMSFAGRLGNWITVHSLN-----LLYKMFTVPAGNAL 222
            .|...|..  .:|...||:...:...|..|:|..||.|:| |:.|.     .||..:.:.|.:.|
Mouse   174 FPCSLEHMLGQSPSPVSYVPRFYTKFSDHMTFPQRLANFI-VNILENYLYYCLYSKYEIIASDLL 237

  Fly   223 IRQRFGPGLPSTEDLVRNTSLMLVNQHFSLSGPKPLPPNVIEVGGVHISPPKPLPSDLQKILD-N 286
            .|.   ..|||    :...||.|:...|....|:|:.||:|.:||::......|..:.:..:: :
Mouse   238 KRD---VSLPS----LHQNSLWLLRYDFVFEYPRPVMPNMIFLGGINCKKKGKLTQEFEAYVNAS 295

  Fly   287 APKGVILISWGSQLKACSLSAARRDGIVKAIGRLEQEVIWKYENDTLPNKPPNLHIRKWLPQRDI 351
            ...|:::.|.||.:.......|..  |.:|:||:.|.|:|:|......|...|..:.|||||.|:
Mouse   296 GEHGIVVFSLGSMVSEIPEKKAME--IAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDL 358

  Fly   352 LAHPNLKVFMSHGGLMGTTEAVSSAVPIVGVPIYGDQSLNIAALVQRGMALQLELKKLDENTVYE 416
            |.||..:.|::|.|..|..|.:.:.||:|.:|::|||..|...:..||..:.|.:.::..:.:..
Mouse   359 LGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLEN 423

  Fly   417 ALTKAL-DPSFKARAKEVASSYNNRIQGPLETAIWWVEHVAETKGAPLTQPSAVHLSRFVYYSLD 480
            ||...: :.|:|.....::|.:.:|...||:.|::|||:|...||||..:|:|..|:.:.|:|||
Mouse   424 ALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLD 488

  Fly   481 VYSVVALSLLLPVITLL 497
            |...: |:::|.|:.::
Mouse   489 VIGFL-LAIVLTVVFIV 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	126/498 (25%)
Ugt1a6a	NP_659545.2	egt	15..503	CDD:223071	138/522 (26%)
Ugt1a6a	NP_659545.2	UDPGT	27..522	CDD:278624	133/510 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840184
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.790