DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36E1 and ugt5a2

DIOPT Version :9

Sequence 1:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001070191.2	Gene:	ugt5a2 / 767756	ZFINID:	ZDB-GENE-061103-373	Length:	524	Species:	Danio rerio

Alignment Length:	555	Identity:	158/555 - (28%)
Similarity:	264/555 - (47%)	Gaps:	83/555 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VFCLLALLSLVAFSDSLRILGLFPHPAISHFKFFHPIMRGLAEAGHSVDVISP-----FEDKDP- 65
            :|.||.:||. :::..|.::.:    ..||:.....::..|...|||:.|:..     .|::.|
Zfish     9 LFLLLCVLSR-SYAGKLLVVPV----EGSHWVNMKVLIVELHSRGHSITVVRGSSSWYIEEQSPL 68

  Fly    66 ------PNGYKD---------HLL----PPSTLTDTISLEDFERPYSFLFHYVEFFILHKMGRED 111
                  .||..|         |||    ...:..:.::|.|      .:.|:|.     :..::.
Zfish    69 YTSITVDNGVFDDDFMEKFLPHLLKIQRQGKSFWNEMALAD------EMIHFVT-----ETHKQS 122

  Fly   112 CNTT---LHSRALTEILKNPPGYYDVILLEQFNTDCAMSVAHVFQAPVIGMSSCALMPW------ 167
            ||.|   ..:..|...||:  ..|||:|     ||.|.. :.|..|..:|:.....:.|
Zfish   123 CNMTAILFENETLMNSLKD--AAYDVVL-----TDPAYG-SGVLLAHRLGLPLVYNVRWTVYGEA 179

  Fly   168 HYERFGAPLIPSYISALFQGQSQEMSFAGRLGNWITVHSLNLLY-KMFTVPAGNALIRQRFGPGL 231
            |::...:||  ||:.......:.:|:|:.|:.|.:|...:...| |.|..|. ..|.::.|||.:
Zfish   180 HFDIAPSPL--SYVPVSGLQLTDKMTFSQRVMNMMTYIMIRYKYSKNFGSPY-QELTQKYFGPNV 241

  Fly   232 PSTEDLVRNTSLMLVNQHFSLSGPKPLPPNVIEVGGVHISPPKPLPSDLQKILDNAPK-GVILIS 295
             :...|:::..|.|:...|:...|:|..|||:.:||....|.||||.||::.:.::.: |||::|
Zfish   242 -NFFSLLQDADLWLMRNDFTFEFPRPTMPNVVYMGGFQCKPAKPLPGDLEEFVQSSGEHGVIMMS 305

  Fly   296 WGSQLKACSLSAARRDGIVKAIGRLEQEVIWKYENDTLPNKPPNLHIRKWLPQRDILAHPNLKVF 360
            .|:...  .|.:...|.|..|..:|.|:|||:|......|...|..|..||||.|:|.||..|:|
Zfish   306 LGTVFG--QLLSELNDEIAAAFAQLPQKVIWRYTGPRPANLGNNTLIVNWLPQNDLLGHPKTKLF 368

  Fly   361 MSHGGLMGTTEAVSSAVPIVGVPIYGDQSLNIAALVQRGMALQLELKKLDENTVYEALTKAL-DP 424
            ::|||..|..||:...|||||:|:..||..|::.:..:|.|..:|...||.....|||.:.| :|
Zfish   369 VAHGGTNGLQEAIYHGVPIVGLPLAFDQPDNLSRMRAKGTAKIVEFATLDRAVFLEALKEVLHNP 433

  Fly   425 SFKARAKEVASSYNNRIQGPLETAIWWVEHVAETKGAPLTQPSAVHLSRFVYYSLDVYSVVALSL 489
            |::...:.::..::::...||:.||:|:|.|...||||..:..:..:|...|.|:||  ::.|.|
Zfish   434 SYRENMQRLSKLHHDQPMKPLDRAIFWIEFVMRNKGAPHLRAQSFRMSWIEYQSIDV--ILTLML 496

  Fly   490 LLPVITLLGLIRM-------FKRREPKGDRKLKRK 517
            ::.|..||.:..|       |:       :|:||:
Zfish   497 MVLVFVLLTVYTMKYFCLCLFR-------KKVKRE 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	139/489 (28%)
ugt5a2	NP_001070191.2	UDPGT	22..524	CDD:278624	152/539 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584277
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.740