DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt36E1 and ugt2a5

DIOPT Version :9

Sequence 1:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001070111.2	Gene:	ugt2a5 / 767705	ZFINID:	ZDB-GENE-060929-796	Length:	532	Species:	Danio rerio

Alignment Length:	517	Identity:	143/517 - (27%)
Similarity:	250/517 - (48%)	Gaps:	54/517 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 SHFKFFHPIMRGLAEAGHSVDVISPFEDKDPPNGYKD----HLL--------PPSTLTDTISL-- 85
            ||:....|::..|.:..|||.|:........|:..|:    |:.        ..:.:.|.|.|
Zfish    31 SHWHNMRPVIEALVDKNHSVTVLVGSSSPTVPHTQKERFEYHVFKVNMEKEEADAAMRDMIHLFT 95

  Fly    86 EDFERPYSFLF-------HYVEFFILHKMGREDCN--TTLHSRALTEILKNPPGYYDVILLEQFN 141
            .|....|...|       .:|||..::..|..|..  .||.......:..:|...:..::.::.|
Zfish    96 NDTAAKYEGEFVMWKVMSKFVEFGDVYFRGLFDVGLLKTLRDSNYDVLFSDPMMPFSDLMAQKLN 160

  Fly   142 TDCAMSVAHVFQAPVIGMSSCALMPWHYERFGAPLIPSYIS--ALFQGQSQEMSFAGRLGNWI-- 202
            ....:|:...|......:  |..||       ||  |||:.  ||....:..|||..|:.|.:
Zfish   161 IPQVISMRATFAYAAERL--CGQMP-------AP--PSYVPAVALTDHLTDRMSFMERVENMLLY 214

  Fly   203 TVHSLNL-LYKMFTVPAGNALIRQRFGPGLPSTE-DLVRNTSLMLVNQHFSLSGPKPLPPNVIEV 265
            .|||:.. |...||.....:.|.     |.|:|. :.:....:.|:..::....|:|.|||...|
Zfish   215 IVHSIAFPLVATFTFDGYYSEIL-----GKPTTMCETMGKVDICLIRTYWDFEYPRPFPPNFKFV 274

  Fly   266 GGVHISPPKPLPSDLQKILDNA-PKGVILISWGSQLKACSLSAARRDGIVKAIGRLEQEVIWKYE 329
            ||:|..|.|||..:|::.:.:: ..||::.|.||.:|  :|::.|.:.|..|:|::.|:|:|:|.
Zfish   275 GGLHCKPAKPLSKELEEFVQSSGDHGVVVFSLGSMIK--NLTSERANTIAAALGQIPQKVVWRYS 337

  Fly   330 NDTLPNKPPNLHIRKWLPQRDILAHPNLKVFMSHGGLMGTTEAVSSAVPIVGVPIYGDQSLNIAA 394
            ..|.....||..|..|:||.|:|.||..|.|::|||..|..||:...||:||:|::|||..|:..
Zfish   338 GKTPETLAPNTKIYDWIPQNDLLGHPKTKAFITHGGTNGLYEAIYHGVPMVGLPLFGDQPDNLLH 402

  Fly   395 LVQRGMALQLELKKLDENTVYEALTKAL--DPSFKARAKEVASSYNNRIQGPLETAIWWVEHVAE 457
            :..:|.|:.|::..:....:.:|| ||:  :||:|.....::..::::...||:.|::|:|.|..
Zfish   403 IKTKGAAVVLDIHTMGSKDLVDAL-KAVVNNPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFVMR 466

  Fly   458 TKGAPLTQPSAVHLSRFVYYSLDVYS-VVALSLLLPVITLLGLIRMFKR--REPKGDRKLKR 516
            .|||...:..|..||.:.|:.|||.: :::::.|:..:.:.....:|:|  |:.:.:||.::
Zfish   467 NKGAKHLRVQAHELSWYQYHCLDVAAFLLSITALITFLWVKACCFLFRRCVRKTRPERKRQK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	127/456 (28%)
ugt2a5	NP_001070111.2	UDPGT	21..519	CDD:278624	140/506 (28%)
ugt2a5	NP_001070111.2	egt	<249..485	CDD:223071	80/238 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584375
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.740