DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt36E1 and UGT8

DIOPT Version :9

Sequence 1:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001121646.2	Gene:	UGT8 / 7368	HGNCID:	12555	Length:	541	Species:	Homo sapiens

Alignment Length:	510	Identity:	150/510 - (29%)
Similarity:	253/510 - (49%)	Gaps:	25/510 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LALLSLVAFSDSLRILGLFPHPAISHFKFFHPIMRGLAEAG-HSVDVISPFEDKDPPNGYKDHLL 74
            :.|.|.|..:.:.:|:.:.|....||...|..:...|.|.| |:|.::|...|..|.|.|.....
Human     9 ILLWSAVGIAKAAKIIIVPPIMFESHMYIFKTLASALHERGHHTVFLLSEGRDIAPSNHYSLQRY 73

  Fly    75 P---PSTLTDTISLEDFERPYSFLFHYVEFFILHKMGREDCNTTLHSRALTEILKNPPGYYDVIL 136
            |   .||.:|..........:|.....:|.|.:.....::|:..:.:.||.:.||...  :|::|
Human    74 PGIFNSTTSDAFLQSKMRNIFSGRLTAIELFDILDHYTKNCDLMVGNHALIQGLKKEK--FDLLL 136

  Fly   137 LEQFNTDCAMSVAHVFQAPVIGMSSCALMP--WHYERFGAPLIPSYISALFQGQSQEMSFAGRLG 199
            ::. |..|...:||     ::|:.......  |:....|||...:|:.......:..|:...|:.
Human   137 VDP-NDMCGFVIAH-----LLGVKYAVFSTGLWYPAEVGAPAPLAYVPEFNSLLTDRMNLLQRMK 195

  Fly   200 NWITVHSLNLLYKMFTVPAGNALIRQRFGPGLP--STEDLVRNTSLMLVNQHFSLSGPKPLPPNV 262
            | ..|:.::.|...|.|......|.|::.. ||  |..|||..:||.::....:|..|:|..|||
Human   196 N-TGVYLISRLGVSFLVLPKYERIMQKYNL-LPEKSMYDLVHGSSLWMLCTDVALEFPRPTLPNV 258

  Fly   263 IEVGGVHISPPKPLPSDLQKILDNAPK-GVILISWGSQLKACSLSAARRDGIVKAIGRLEQEVIW 326
            :.|||:...|..|||.|||:.::.|.: |.:|:|:|:.:|..|...|.:  :..|:|||.|:|||
Human   259 VYVGGILTKPASPLPEDLQRWVNGANEHGFVLVSFGAGVKYLSEDIANK--LAGALGRLPQKVIW 321

  Fly   327 KYENDTLPNKPPNLHIRKWLPQRDILAHPNLKVFMSHGGLMGTTEAVSSAVPIVGVPIYGDQSLN 391
            ::......|...|..:.:||||.|:|.|..:|.|:|||||....|.:...||:||:|::||....
Human   322 RFSGPKPKNLGNNTKLIEWLPQNDLLGHSKIKAFLSHGGLNSIFETIYHGVPVVGIPLFGDHYDT 386

  Fly   392 IAALVQRGMALQLELKKLDENTVYEALTKAL-DPSFKARAKEVASSYNNRIQGPLETAIWWVEHV 455
            :..:..:||.:.||.|.:.|..:||||.|.: :||::.||::::..:.::...|:...|:|::::
Human   387 MTRVQAKGMGILLEWKTVTEKELYEALVKVINNPSYRQRAQKLSEIHKDQPGHPVNRTIYWIDYI 451

  Fly   456 AETKGAPLTQPSAVHLSRFV-YYSLDVYSVVALSLLLPVITLLGLIRMFKRREPK 509
            ....||...: :|||...|. |:.||:..|:.|...| :..||..:..|..|:.|
Human   452 IRHNGAHHLR-AAVHQISFCQYFLLDIAFVLLLGAAL-LYFLLSWVTKFIYRKIK 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	133/458 (29%)
UGT8	NP_001121646.2	Glycosyltransferase_GTB-type	21..502	CDD:415824	145/494 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150169
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.678979	Normalized mean entropy	S5661
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.690