DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36E1 and UGT2B10

DIOPT Version :9

Sequence 1:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001066.1	Gene:	UGT2B10 / 7365	HGNCID:	12544	Length:	528	Species:	Homo sapiens

Alignment Length:	513	Identity:	139/513 - (27%)
Similarity:	249/513 - (48%)	Gaps:	69/513 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 IMRGLAEAGHSVDVISP-----FEDKDPPNGYKDHLLP--PSTLTDT---------------ISL 85
            |::.|.:.||.|.|::.     |:    ||......|.  |::||.|               |..
Human    41 ILKELVQRGHEVTVLASSASILFD----PNDSSTLKLEVYPTSLTKTEFENIIMQLVKRLSEIQK 101

  Fly    86 EDFERPYSFLFHYVEFFILHKMG---REDCNTTLHSRALTEILKNPPGYYDVILLEQFNTDCAMS 147
            :.|..|:|     .|..||..:.   |..|...:.::.|.:.|:.  ..:|::..:.: ..|...
Human   102 DTFWLPFS-----QEQEILWAINDIIRNFCKDVVSNKKLMKKLQE--SRFDIVFADAY-LPCGEL 158

  Fly   148 VAHVFQAPVIGMSSCALMP-WHYERFGAPLI--PSYISALFQGQSQEMSFAGRLGNWITVHSLNL 209
            :|.:|..|.:  .|.:..| :.:||.....|  |||:..:....|.:|:|..|:.|.:.|...:.
Human   159 LAELFNIPFV--YSHSFSPGYSFERHSGGFIFPPSYVPVVMSKLSDQMTFMERVKNMLYVLYFDF 221

  Fly   210 LYKMFTVPAGNALIRQRFGPGLPST-EDLVRNTSLMLVNQHFSLSGPKPLPPNVIEVGGVHISPP 273
            .:::|.:...:....:..  |.|:| .:.:|...:.|:...::...|.|..|||..|||:|..|.
Human   222 WFQIFNMKKWDQFYSEVL--GRPTTLSETMRKADIWLMRNSWNFKFPHPFLPNVDFVGGLHCKPA 284

  Fly   274 KPLPSDLQKILDNA-PKGVILISWGSQLKACSLSAARRDGIVKAIGRLEQEVIWKYENDTLPNKP 337
            ||||.::::.:.:: ..||::.|.||.:.  :::..|.:.|..|:.::.|:|:|:::.    |||
Human   285 KPLPKEMEEFVQSSGENGVVVFSLGSMVS--NMTEERANVIATALAKIPQKVLWRFDG----NKP 343

  Fly   338 P----NLHIRKWLPQRDILAHPNLKVFMSHGGLMGTTEAVSSAVPIVGVPIYGDQSLNIAALVQR 398
            .    |..:.||:||.|:|.||..:.|::|||..|..||:...:|:||:|::.||..|||.:..:
Human   344 DALGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAK 408

  Fly   399 GMALQLELKKLDENTVYEALTKAL-DPSFKARAKEVASSYNNRIQGPLETAIWWVEHVAETKGAP 462
            |.|::::...:....:..||...: |||:|....:::...:::...||:.|::|:|.|...|||.
Human   409 GAAVRVDFNTMSSTDLLNALKTVINDPSYKENIMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAK 473

  Fly   463 LTQPSAVHLSRFVYYSLDVYSVVALSLLLPVITLLGLIR--------MFKRREPKGDR 512
            ..:.:|.:|:.|.|:||||...    ||..|.|:|.:|.        .|.|:..||.|
Human   474 HLRVAAHNLTWFQYHSLDVIGF----LLACVATVLFIITKCCLFCFWKFARKGKKGKR 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	117/451 (26%)
UGT2B10	NP_001066.1	UDPGT	23..524	CDD:278624	136/508 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150139
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.740