Protein Alignment Ugt36E1 and UGT2B7

DIOPT Version :10

• Sequence 1: NP_609911.1
• Gene: Ugt36E1 / 35139
• FlyBaseID: FBgn0027070
• Length: 517
• Species: Drosophila melanogaster
• Sequence 2: NP_001065.2
• Gene: UGT2B7 / 7364
• HGNCID: 12554
• Length: 529
• Species: Homo sapiens
• Alignment Length: 507
• Identity: 136/507 - (26%)
• Similarity: 253/507 - (49%)
• Gaps: 45/507 - (8%)

  Fly    35 SHFKFFHPIMRGLAEAGHSVDVISPFED--KDPPNGYKDHL-LPPSTLTDTISLEDF-------- 88
            ||:.....|:..|.:.||.|.|::....  .||.|.....: :.|::||.| .||:|
Human    34 SHWMNIKTILDELIQRGHEVTVLASSASILFDPNNSSALKIEIYPTSLTKT-ELENFIMQQIKRW 97

  Fly    89 ----ERPYSFLFHYVE--FFILHKMGREDCNTTLHSRALTEILKNPPGYYDVILLEQFNTDCAMS 147
                :..:...|..|:  ..|...:.|:.|...:.::...:  |.....:|||..:.. ..|:..
Human    98 SDLPKDTFWLYFSQVQEIMSIFGDITRKFCKDVVSNKKFMK--KVQESRFDVIFADAI-FPCSEL 159

  Fly   148 VAHVFQAPVIGMSSCALMP-WHYERFGAPLI--PSYISALFQGQSQEMSFAGRLGNWITVHSLNL 209
            :|.:|..|.:  .|.:..| :.:|:.....|  |||:..:....:.:|:|..|:.|.|.|...:.
Human   160 LAELFNIPFV--YSLSFSPGYTFEKHSGGFIFPPSYVPVVMSELTDQMTFMERVKNMIYVLYFDF 222

  Fly   210 LYKMFTVPAGNALIRQRFGPGLPST-EDLVRNTSLMLVNQHFSLSGPKPLPPNVIEVGGVHISPP 273
            .:::|.:...:....:..  |.|:| .:.:....:.|:...::...|.||.|||..|||:|..|.
Human   223 WFEIFDMKKWDQFYSEVL--GRPTTLSETMGKADVWLIRNSWNFQFPYPLLPNVDFVGGLHCKPA 285

  Fly   274 KPLPSDLQKILDNA-PKGVILISWGSQLKACSLSAARRDGIVKAIGRLEQEVIWKYENDTLPNKP 337
            ||||.:::..:.:: ..||::.|.||.:.  :::..|.:.|..|:.::.|:|:|:::.    |||
Human   286 KPLPKEMEDFVQSSGENGVVVFSLGSMVS--NMTEERANVIASALAQIPQKVLWRFDG----NKP 344

  Fly   338 P----NLHIRKWLPQRDILAHPNLKVFMSHGGLMGTTEAVSSAVPIVGVPIYGDQSLNIAALVQR 398
            .    |..:.||:||.|:|.||..:.|::|||..|..||:...:|:||:|::.||..|||.:..|
Human   345 DTLGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFADQPDNIAHMKAR 409

  Fly   399 GMALQLELKKLDENTVYEALTKAL-DPSFKARAKEVASSYNNRIQGPLETAIWWVEHVAETKGAP 462
            |.|::::...:....:..||.:.: |||:|....:::...:::...||:.|::|:|.|...|||.
Human   410 GAAVRVDFNTMSSTDLLNALKRVINDPSYKENVMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAK 474

  Fly   463 LTQPSAVHLSRFVYYSLDV--YSVVALSLLLPVITLLGLIRMFK--RREPKG 510
            ..:.:|..|:.|.|:||||  :.:|.::.::.::|...|...:|  |:..||
Human   475 HLRVAAHDLTWFQYHSLDVIGFLLVCVATVIFIVTKCCLFCFWKFARKAKKG 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36E1	NP_609911.1	GT1_Gtf-like	23..453	CDD:340817	116/444 (26%)
UGT2B7	NP_001065.2	UDPGT	24..525	CDD:278624	134/504 (27%)