DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36E1 and Ugt2a3

DIOPT Version :9

Sequence 1:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_082370.2	Gene:	Ugt2a3 / 72094	MGIID:	1919344	Length:	534	Species:	Mus musculus

Alignment Length:	528	Identity:	143/528 - (27%)
Similarity:	247/528 - (46%)	Gaps:	73/528 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 ISHFKFFHPIMRGLAEAGHSVDVIS------------PFEDKDPPNGYK---------------D 71
            :||:.....|:..|...||.|.|:.            |...::.|..|:               .
Mouse    33 MSHWLNLKTILEELGARGHEVTVLKYPSIIIDQSKRIPLHFENIPLLYEIETAENRLNEIANLAV 97

  Fly    72 HLLPPSTLTDTI-SLEDFERPYSFLFHYVEFFILHKMGREDCNTTLHSRALTEILKNPPGYYDVI 135
            :::|..:|.:.. :|:||     ||....:|       ...|.:.|:::...:.|::  ..|||:
Mouse    98 NVIPNLSLWEAAKTLQDF-----FLQVTGDF-------ESICRSVLYNQKFMDKLRD--AQYDVV 148

  Fly   136 LLEQFNTDCAMSVAHVFQAP---VIGMSSCALMPWHYERFGAPLIPSYISALFQGQSQEMSFAGR 197
            :::.. ..|...||.|.|.|   .:..|....|..|..:...||  ||:..:....:..|:|..|
Mouse   149 VIDPV-VPCGELVAEVLQIPFVYTLRFSMGYYMEKHCGQLPIPL--SYVPVVMSELTDNMTFTER 210

  Fly   198 LGNWITVHSLNLLYKMFTVPAGNALIRQRFGP--GLPSTE-DLVRNTSLMLVNQHFSLSGPKPLP 259
            :.|.:    .:||::.:......|...|.:..  |.|:|. ..|....:.|:..::.:..|:|..
Mouse   211 VKNMM----FSLLFEYWLQQYDFAFWDQFYSETLGRPTTFCKTVGKADIWLIRTYWDVEFPRPYL 271

  Fly   260 PNVIEVGGVHISPPKPLPSDLQKILDNAPK-GVILISWGSQLKACSLSAARRDGIVKAIGRLEQE 323
            ||...|||:|..|.||||.::::.:.::.: ||::.|.||.:|  :|:..:.:.|...:.::.|:
Mouse   272 PNFEFVGGLHCKPAKPLPKEMEEFVQSSGEHGVVVFSLGSMVK--NLTEEKANLIASVLAQIPQK 334

  Fly   324 VIWKYENDTLPNKPPNLHIRKWLPQRDILAHPNLKVFMSHGGLMGTTEAVSSAVPIVGVPIYGDQ 388
            |:|:|..........|..:..|:||.|:|.||..|.|::|||..|..||:...||:||||:.|||
Mouse   335 VLWRYSGKKPATLGSNTRLFNWIPQNDLLGHPKTKAFITHGGTNGIYEAIYHGVPMVGVPMLGDQ 399

  Fly   389 SLNIAALVQRGMALQLELKKLDENTVYEALTKAL-DPSFKARAKEVASSYNNRIQGPLETAIWWV 452
            ..|||.:..:|.||::.:..:....:..|:...: :||:|..|..::..::::...||:.|::|:
Mouse   400 PHNIAHMEAKGAALKVSISTMTSTDLLSAVRAVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWI 464

  Fly   453 EHVAETKGAPLTQPSAVHLSRFVYYSLDVYSVVALSLLLPVITLLGLIRMF----------KRRE 507
            |.|...|||...:.:|..||.|.|:||||...    |||.|:||..:|..|          |..:
Mouse   465 EFVMRHKGAKHLRVAAHDLSWFQYHSLDVIGF----LLLCVVTLTFIITKFCLFVCQKLYMKESK 525

  Fly   508 PKGDRKLK 515
            ..|:||.|
Mouse   526 KMGNRKKK 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	118/461 (26%)
Ugt2a3	NP_082370.2	UDPGT	25..526	CDD:278624	139/519 (27%)
Ugt2a3	NP_082370.2	egt	<268..507	CDD:223071	84/244 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840117
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.790