DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt36E1 and Ugt2b1

DIOPT Version :9

Sequence 1:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_690024.1	Gene:	Ugt2b1 / 71773	MGIID:	1919023	Length:	529	Species:	Mus musculus

Alignment Length:	501	Identity:	136/501 - (27%)
Similarity:	245/501 - (48%)	Gaps:	60/501 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 SHFKFFHPIMRGLAEAGHSVDVISPFEDKDPPNGYKDHLLPPSTLTDTISLEDFERP-------Y 92
            ||:.....|:..|.:.||.|.|:.         .....|:.||. ..:|:.|.:..|       |
Mouse    34 SHWINMKIILDELVQRGHDVTVLI---------SSASILIGPSN-ESSINFEIYSAPLSKDDLEY 88

  Fly    93 SF-------------LFHYVEFFILHKMGRE-------DCNTTLHSRALTEILKNPPGYYDVILL 137
            :|             |..:..:..|.|:..|       .|...:.:::|.:.|:.  ..:||:|.
Mouse    89 AFEKWVGNWTYELKKLPFWTSYSKLQKISSEYSDMIESFCKAVVWNKSLMKKLQG--SKFDVVLA 151

  Fly   138 EQFNTDCAMSVAHVFQAPVIGMSSCALMP-WHYERF--GAPLIPSYISALFQGQSQEMSFAGRLG 199
            :.. ..|...::.:.:.|::  .|....| :..|::  |.||.|||:..:....|..|:||.|:.
Mouse   152 DAL-VPCGELLSELLKTPLV--YSLRFCPGYKCEKYSGGLPLPPSYVPVVLSELSDHMTFAERVK 213

  Fly   200 NWITVHSLNLLYKMFTVPAGNALIRQRFGPGLPSTEDLVRNTSLMLVNQHFSLSGPKPLPPNVIE 264
            |.:.|...:..::.|...:.|.......|.....|| ::....:.||...:.|..|.|..||...
Mouse   214 NMLQVLLFDFWFQTFNEKSWNQFYSDVLGRPTTLTE-MMGKADIWLVRTFWDLKFPHPFLPNFDF 277

  Fly   265 VGGVHISPPKPLPSDLQKILDNAPK-GVILISWGSQLKACSLSAARRDGIVKAIGRLEQEVIWKY 328
            |||:|..|.||||.::::.:.::.: ||::.|.||.:|  ::...:.:.:..|:.::.|:|:|::
Mouse   278 VGGLHCKPAKPLPKEMEEFVQSSGEHGVVVFSLGSMVK--NIKEEKANVVASALAQIPQKVLWRF 340

  Fly   329 EN---DTLPNKPPNLHIRKWLPQRDILAHPNLKVFMSHGGLMGTTEAVSSAVPIVGVPIYGDQSL 390
            :.   |||.:   |..:.||:||.|:|.||..|.|::|||..|..||:...:||||:|::|||..
Mouse   341 DGKKPDTLGS---NTRLYKWIPQNDLLGHPKTKAFIAHGGTNGIYEAIYHGIPIVGIPLFGDQPD 402

  Fly   391 NIAALVQRGMALQLELKKLDENTVYEALTKAL-DPSFKARAKEVASSYNNRIQGPLETAIWWVEH 454
            ||..:|.:|.|::::...:....:..||...: |||:|..|..::..::::...||:.|::|:|:
Mouse   403 NINHIVAKGAAVRVDFDTMSTTDLLTALKTVINDPSYKENAMRLSRIHHDQPMKPLDRAVFWIEY 467

  Fly   455 VAETKGAPLTQPSAVHLSRFVYYSLDVYSVVALSLLLPVITLLGLI 500
            |...|||...:|:...|:.|.|:||||...    ||:.|:.::.:|
Mouse   468 VMRNKGAKHLRPALHDLTWFQYHSLDVIGF----LLVCVVAVVFII 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	121/459 (26%)
Ugt2b1	NP_690024.1	egt	8..508	CDD:223071	135/498 (27%)
Ugt2b1	NP_690024.1	UDPGT	24..527	CDD:278624	136/501 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840149
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.790