DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36E1 and Ugt1a8

DIOPT Version :9

Sequence 1:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001365304.1	Gene:	Ugt1a8 / 613123	MGIID:	3576090	Length:	530	Species:	Mus musculus

Alignment Length:	519	Identity:	139/519 - (26%)
Similarity:	242/519 - (46%)	Gaps:	60/519 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 CLLALLSLVAFSDSLRILGLFPHPAISHFKFFHPIMRGLAEAGHSVDVISPFEDKDPPNGYKDHL 73
            |||....|   :.:.|:| :.|... ||:.....|:..|:..||.|.|:.|        ....||
Mouse    15 CLLLAFGL---AQAGRLL-VVPMDG-SHWFSMKMIVEKLSHRGHEVVVVIP--------EVSWHL 66

  Fly    74 -----LPPSTLTDTISLEDFERPYSFLFH-------YVEFFILHKMGR-------EDCNTTLHSR 119
                 ....|.:.:.:|||....::|..|       ...|.:|...|:       ..|.:..:.:
Mouse    67 GKSQNFTVKTYSVSYTLEDLSHHFNFFAHKQWENREVGMFSLLKHSGKGFFQVLFSHCRSLFNDK 131

  Fly   120 ALTEILKNPPGYYDVILLEQFNTDCAMSVAHVFQAPVIGMSS---CALMPWHYERFGA--PLIPS 179
            .|.|.||...  :|.:.|:.|:. |.:::|..|..|.:..|.   |     ||...||  |..||
Mouse   132 KLVEYLKQRS--FDAVFLDPFDV-CGLTIAKYFSLPSVVFSGGIFC-----HYLDEGAQCPSPPS 188

  Fly   180 YISALFQGQSQEMSFAGRLGNWITVHSLNLLYKMF---TVPAGNALIRQRFGPGLPST-EDLVRN 240
            |:..:....:..|:|..|:.|:.:..........|   .:...:.:::      .|.| .||..:
Mouse   189 YVPRILSKFADTMTFKERVWNYFSYMKERAFCPYFFKTAIEIASEVLQ------TPVTMTDLFSS 247

  Fly   241 TSLMLVNQHFSLSGPKPLPPNVIEVGGVHISPPKPLPSDLQKILD-NAPKGVILISWGSQLKACS 304
            .|:.:....|.|..|:|:.||::.:||::..|.|||..:.:..:: :...|:::.|.||.:....
Mouse   248 VSIWMFRTDFVLEFPRPVMPNMVYIGGINCHPGKPLSKEFEAYVNASGEHGIVVFSLGSMVSEIP 312

  Fly   305 LSAARRDGIVKAIGRLEQEVIWKYENDTLPNKPPNLHIRKWLPQRDILAHPNLKVFMSHGGLMGT 369
            ...|..  |.:|:||:.|.|:|:|......|...|..:.|||||.|:|.||..:.|::|.|..|.
Mouse   313 EKKAME--IAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHGI 375

  Fly   370 TEAVSSAVPIVGVPIYGDQSLNIAALVQRGMALQLELKKLDENTVYEALTKAL-DPSFKARAKEV 433
            .|.:.:.||:|.:|::|||..|...:..||..:.|.:.::..:.:..||...: :.|:|.....:
Mouse   376 YEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRL 440

  Fly   434 ASSYNNRIQGPLETAIWWVEHVAETKGAPLTQPSAVHLSRFVYYSLDVYSVVALSLLLPVITLL 497
            :|.:.:|...||:.|::|||:|...||||..:|:|..|:.:.|:||||...: |:::|.|:.::
Mouse   441 SSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFL-LAIVLTVVFIV 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	124/480 (26%)
Ugt1a8	NP_001365304.1	UDPGT	26..521	CDD:278624	135/505 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840129
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.790