DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36E1 and Ugt2a2

DIOPT Version :9

Sequence 1:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001019319.1	Gene:	Ugt2a2 / 552899	MGIID:	3576095	Length:	528	Species:	Mus musculus

Alignment Length:	529	Identity:	136/529 - (25%)
Similarity:	250/529 - (47%)	Gaps:	80/529 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 SHFKFFHPIMRGLAEAGHSVDVISPFEDKDPPNGYKDHLLPPSTLTDTISLEDFERPYS------ 93
            ||:.....::..|.:..|||.|::|.|.          |...|.|...|:.|:....|:
Mouse    32 SHWLNIKILLEELVQRNHSVTVLAPSET----------LFINSRLDAFINFEEIPVSYTKSKIDE 86

  Fly    94 FLFHYVEFFILHK----------------------MGREDCNTTLHSRALTEILKNPPGYYDVIL 136
            .:.|.:..::.|:                      ..::.|:..|::..:.|.|:.  |.:||:|
Mouse    87 IIEHMIALWLDHRPTPLTMWTFYKELGNLLATFYTTNKQMCDGVLNNPTVMERLQK--GGFDVLL 149

  Fly   137 LEQFNTDCAMSVAHVFQAP---VIGMSSCALMPWHYERFGAPLIPSYISALFQGQSQEMSFAGRL 198
            .:.. |.|...||.....|   .:..|....:..|..:..||:  ||:.|.....:.:|||..|:
Mouse   150 ADPV-TMCGELVALKLGIPFVYTLRFSPAFTVERHCGKIPAPI--SYVPAALSELTDQMSFGERV 211

  Fly   199 GNWITVHSLNLLYKMFTVPAGNALIRQRFGP---------GLPSTE-DLVRNTSLMLVNQHFSLS 253
            .|.|:....:.::|.:            :|.         |.|:|. :.:....:.|:..::...
Mouse   212 KNIISYSLQDYIFKTY------------WGEWNSYYSKVLGRPTTLCETMGKAEIWLMRTYWDFE 264

  Fly   254 GPKPLPPNVIEVGGVHISPPKPLPSDLQKILDNAPK-GVILISWGSQLKACSLSAARRDGIVKAI 317
            .|:|..||...|||:|..|.||||.::::.:..:.: |:::.|.||.:|  :|:..:.:.|..|:
Mouse   265 FPRPYLPNFEFVGGLHCKPAKPLPKEMEEFVQTSGEHGIVVFSLGSMVK--NLTDEKANLIASAL 327

  Fly   318 GRLEQEVIWKYEN---DTLPNKPPNLHIRKWLPQRDILAHPNLKVFMSHGGLMGTTEAVSSAVPI 379
            .::.|:|:|:|:.   |||.:   |..:..|:||.|:|.||..:.|::|||..|..||:...:|:
Mouse   328 AQIPQKVLWRYKGKIPDTLGS---NTRLFDWIPQNDLLGHPKTRAFITHGGTNGIYEAIYHGIPM 389

  Fly   380 VGVPIYGDQSLNIAALVQRGMALQLELKKLDENTVYEALTKAL-DPSFKARAKEVASSYNNRIQG 443
            ||||::.||..|||.:..:|.|:::.:..:..:.:..||...: :||:|..|..::..::::...
Mouse   390 VGVPMFADQPDNIAHMKAKGAAVEVNMNTMTSSDLLNALRTVINEPSYKENAMRLSRIHHDQPVK 454

  Fly   444 PLETAIWWVEHVAETKGAPLTQPSAVHLSRFVYYSLDVYSVVALSLLLPVITLLGLIRMF-KRRE 507
            ||:.|::|:|.|...|||...:.:|..||.|.|:||||...: |:.:...|.|:....:| .::.
Mouse   455 PLDRAVFWIEFVMRHKGAKHLRVAAHDLSWFQYHSLDVIGFL-LACVASAILLVAKCCLFIFQKV 518

  Fly   508 PKGDRKLKR 516
            .|..:|.||
Mouse   519 GKTGKKKKR 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	116/470 (25%)
Ugt2a2	NP_001019319.1	UDPGT	22..516	CDD:278624	132/516 (26%)
Ugt2a2	NP_001019319.1	egt	<267..487	CDD:223071	73/224 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840107
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.790