DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36E1 and UGT1A3

DIOPT Version :9

Sequence 1:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_061966.1	Gene:	UGT1A3 / 54659	HGNCID:	12535	Length:	534	Species:	Homo sapiens

Alignment Length:	515	Identity:	136/515 - (26%)
Similarity:	246/515 - (47%)	Gaps:	38/515 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 WKVFCLLALLSLVAFSDSLRILGLFPHPAISHFKFFHPIMRGLAEAGHSVDVISPFEDKDPPNGY 69
            |....||.|||:..:::|.::| :.|... ||:.....::|.|...||...|::|     ..|.:
Human    11 WLATGLLLLLSVQPWAESGKVL-VVPIDG-SHWLSMREVLRELHARGHQAVVLTP-----EVNMH 68

  Fly    70 --KDHLLPPSTLTDTISLEDFER---PYSFLFHYVEFFI---------LHKMG---REDCNTTLH 117
              :::....:|...:.:.::|:|   .::.|:...|.|:         |:.|.   ...|...||
Human    69 IKEENFFTLTTYAISWTQDEFDRHVLGHTQLYFETEHFLKKFFRSMAMLNNMSLVYHRSCVELLH 133

  Fly   118 SRALTEILKNPPGYYDVILLEQFNTDCAMSVAHVFQAPVIGMSSCALMPWHYERFGAPLIPSYIS 182
            :.||...|....  :||:|.:..|. ||..:|.....|.:...........::....|...|||.
Human   134 NEALIRHLNATS--FDVVLTDPVNL-CAAVLAKYLSIPTVFFLRNIPCDLDFKGTQCPNPSSYIP 195

  Fly   183 ALFQGQSQEMSFAGRLGNWITVHSLNLLYKMFTVPAGNALIRQRFGPGLPSTEDLVRNTSLMLVN 247
            .|....|..|:|..|:.|.:...:|:.:...|:.|.. :|..:.|...: |..|::.:.|:.|..
Human   196 RLLTTNSDHMTFMQRVKNMLYPLALSYICHAFSAPYA-SLASELFQREV-SVVDILSHASVWLFR 258

  Fly   248 QHFSLSGPKPLPPNVIEVGGVHISPPKPLPSDLQKILD-NAPKGVILISWGSQLKACSLSAARRD 311
            ..|.:..|:|:.||::.:||::.:..|||..:.:..:: :...|:::.|.||.:.  .:...:..
Human   259 GDFVMDYPRPIMPNMVFIGGINCANRKPLSQEFEAYINASGEHGIVVFSLGSMVS--EIPEKKAM 321

  Fly   312 GIVKAIGRLEQEVIWKYENDTLPNKPPNLHIRKWLPQRDILAHPNLKVFMSHGGLMGTTEAVSSA 376
            .|..|:|::.|.|:|:|......|...|..:.|||||.|:|.||..:.|::|.|..|..|::.:.
Human   322 AIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNG 386

  Fly   377 VPIVGVPIYGDQSLNIAALVQRGMALQLELKKLDENTVYEALTKAL-DPSFKARAKEVASSYNNR 440
            ||:|.:|::|||..|...:..:|..:.|.:.::....:..||...: |.|:|.....::|.:.:|
Human   387 VPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDR 451

  Fly   441 IQGPLETAIWWVEHVAETKGAPLTQPSAVHLSRFVYYSLDVYSVVALSLLLPVITLLGLI 500
            ...||:.|::|||.|...||||..:|:|..|:.:.|:||||     :..||.|:..:..|
Human   452 PVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDV-----IGFLLAVVLTVAFI 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	120/473 (25%)
UGT1A3	NP_061966.1	UDPGT	29..525	CDD:278624	129/497 (26%)
UGT1A3	NP_061966.1	egt	<262..508	CDD:223071	76/252 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150157
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.840