Protein Alignment Ugt36E1 and UGT1A3

DIOPT Version :10

• Sequence 1: NP_609911.1
• Gene: Ugt36E1 / 35139
• FlyBaseID: FBgn0027070
• Length: 517
• Species: Drosophila melanogaster
• Sequence 2: NP_061966.1
• Gene: UGT1A3 / 54659
• HGNCID: 12535
• Length: 534
• Species: Homo sapiens
• Alignment Length: 515
• Identity: 136/515 - (26%)
• Similarity: 246/515 - (47%)
• Gaps: 38/515 - (7%)

  Fly     5 WKVFCLLALLSLVAFSDSLRILGLFPHPAISHFKFFHPIMRGLAEAGHSVDVISPFEDKDPPNGY 69
            |....||.|||:..:::|.::| :.|... ||:.....::|.|...||...|::|     ..|.:
Human    11 WLATGLLLLLSVQPWAESGKVL-VVPIDG-SHWLSMREVLRELHARGHQAVVLTP-----EVNMH 68

  Fly    70 --KDHLLPPSTLTDTISLEDFER---PYSFLFHYVEFFI---------LHKMG---REDCNTTLH 117
              :::....:|...:.:.::|:|   .::.|:...|.|:         |:.|.   ...|...||
Human    69 IKEENFFTLTTYAISWTQDEFDRHVLGHTQLYFETEHFLKKFFRSMAMLNNMSLVYHRSCVELLH 133

  Fly   118 SRALTEILKNPPGYYDVILLEQFNTDCAMSVAHVFQAPVIGMSSCALMPWHYERFGAPLIPSYIS 182
            :.||...|....  :||:|.:..|. ||..:|.....|.:...........::....|...|||.
Human   134 NEALIRHLNATS--FDVVLTDPVNL-CAAVLAKYLSIPTVFFLRNIPCDLDFKGTQCPNPSSYIP 195

  Fly   183 ALFQGQSQEMSFAGRLGNWITVHSLNLLYKMFTVPAGNALIRQRFGPGLPSTEDLVRNTSLMLVN 247
            .|....|..|:|..|:.|.:...:|:.:...|:.|.. :|..:.|...: |..|::.:.|:.|..
Human   196 RLLTTNSDHMTFMQRVKNMLYPLALSYICHAFSAPYA-SLASELFQREV-SVVDILSHASVWLFR 258

  Fly   248 QHFSLSGPKPLPPNVIEVGGVHISPPKPLPSDLQKILD-NAPKGVILISWGSQLKACSLSAARRD 311
            ..|.:..|:|:.||::.:||::.:..|||..:.:..:: :...|:::.|.||.:.  .:...:..
Human   259 GDFVMDYPRPIMPNMVFIGGINCANRKPLSQEFEAYINASGEHGIVVFSLGSMVS--EIPEKKAM 321

  Fly   312 GIVKAIGRLEQEVIWKYENDTLPNKPPNLHIRKWLPQRDILAHPNLKVFMSHGGLMGTTEAVSSA 376
            .|..|:|::.|.|:|:|......|...|..:.|||||.|:|.||..:.|::|.|..|..|::.:.
Human   322 AIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNG 386

  Fly   377 VPIVGVPIYGDQSLNIAALVQRGMALQLELKKLDENTVYEALTKAL-DPSFKARAKEVASSYNNR 440
            ||:|.:|::|||..|...:..:|..:.|.:.::....:..||...: |.|:|.....::|.:.:|
Human   387 VPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDR 451

  Fly   441 IQGPLETAIWWVEHVAETKGAPLTQPSAVHLSRFVYYSLDVYSVVALSLLLPVITLLGLI 500
            ...||:.|::|||.|...||||..:|:|..|:.:.|:||||     :..||.|:..:..|
Human   452 PVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDV-----IGFLLAVVLTVAFI 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36E1	NP_609911.1	GT1_Gtf-like	23..453	CDD:340817	110/448 (25%)
UGT1A3	NP_061966.1	UDPGT	29..525	CDD:278624	129/497 (26%)