Protein Alignment Ugt36E1 and UGT1A1

DIOPT Version :10

• Sequence 1: NP_609911.1
• Gene: Ugt36E1 / 35139
• FlyBaseID: FBgn0027070
• Length: 517
• Species: Drosophila melanogaster
• Sequence 2: NP_000454.1
• Gene: UGT1A1 / 54658
• HGNCID: 12530
• Length: 533
• Species: Homo sapiens
• Alignment Length: 516
• Identity: 137/516 - (26%)
• Similarity: 235/516 - (45%)
• Gaps: 51/516 - (9%)

  Fly    10 LLALLSLVAFSDSLRILGLFPHPAISHFKFFHPIMRGLAEAGHSVDVISPFEDKDPPNG----YK 70
            ||.:|..|. |.:.:|| |.|... ||:......::.|.:.||.:.|::|.......:|    .|
Human    16 LLCVLGPVV-SHAGKIL-LIPVDG-SHWLSMLGAIQQLQQRGHEIVVLAPDASLYIRDGAFYTLK 77

  Fly    71 DHLLPPSTLTDTISLEDFERPYSFLFHYV---EFFI-----LHKMGRED-------CNTTLHSRA 120
            .:.:|       ...||.:..:..|.|.|   :.|:     .:|..::|       |:..||::.
Human    78 TYPVP-------FQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDSAMLLSGCSHLLHNKE 135

  Fly   121 LTEILKNPPGYYDVILLEQFNTDCAMSVAHVFQAPVIGMSSCALMPWHYERFGAPLIPSYISALF 185
            |...|..  ..:||:|.:.| ..|:..||.....|.:...........:|....|...||:....
Human   136 LMASLAE--SSFDVMLTDPF-LPCSPIVAQYLSLPTVFFLHALPCSLEFEATQCPNPFSYVPRPL 197

  Fly   186 QGQSQEMSFAGRLGNWITVHSLNLL----YKMFTVPAGNALIRQRFGPGLPSTEDLVRNTSLMLV 246
            ...|..|:|..|:.|.:...|.|.|    |..:...|...|.|:      .:.:||:.:.|:.|.
Human   198 SSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLASEFLQRE------VTVQDLLSSASVWLF 256

  Fly   247 NQHFSLSGPKPLPPNVIEVGGVHISPPKPLPSDLQKILD-NAPKGVILISWGSQLKACSLSAARR 310
            ...|....|:|:.||::.|||::.....||..:.:..:: :...|:::.|.||.:.  .:...:.
Human   257 RSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEHGIVVFSLGSMVS--EIPEKKA 319

  Fly   311 DGIVKAIGRLEQEVIWKYENDTLPNKPPNLHIRKWLPQRDILAHPNLKVFMSHGGLMGTTEAVSS 375
            ..|..|:|::.|.|:|:|......|...|..:.|||||.|:|.||..:.|::|.|..|..|::.:
Human   320 MAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICN 384

  Fly   376 AVPIVGVPIYGDQSLNIAALVQRGMALQLELKKLDENTVYEALTKAL-DPSFKARAKEVASSYNN 439
            .||:|.:|::|||..|...:..:|..:.|.:.::....:..||...: |.|:|.....::|.:.:
Human   385 GVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKD 449

  Fly   440 RIQGPLETAIWWVEHVAETKGAPLTQPSAVHLSRFVYYSLDVYSVVALSLLLPVITLLGLI 500
            |...||:.|::|||.|...||||..:|:|..|:.:.|:||||     :..||.|:..:..|
Human   450 RPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDV-----IGFLLAVVLTVAFI 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36E1	NP_609911.1	GT1_Gtf-like	23..453	CDD:340817	113/454 (25%)
UGT1A1	NP_000454.1	UDPGT	28..524	CDD:278624	132/503 (26%)