DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36E1 and UGT1A4

DIOPT Version :9

Sequence 1:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_009051.1	Gene:	UGT1A4 / 54657	HGNCID:	12536	Length:	534	Species:	Homo sapiens

Alignment Length:	527	Identity:	140/527 - (26%)
Similarity:	239/527 - (45%)	Gaps:	72/527 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLALLSLVAFSDSLRILGLFP---HPAISHFKFFHPIMRGLAEAGHSVDVISPFEDKDPPNGYKD 71
            ||.|||:..:::|.::| :.|   .|.:|    ....:|.|...||...|::|..:.
Human    16 LLLLLSVQPWAESGKVL-VVPTDGSPWLS----MREALRELHARGHQAVVLTPEVNM-------- 67

  Fly    72 HLLPPSTLTDTI-----SLEDFER---PYSFLFHYVEFFI----------------LHKMGREDC 112
            |:......|.|.     :.::|:|   .|:..|...|..:                ||:.    |
Human    68 HIKEEKFFTLTAYAVPWTQKEFDRVTLGYTQGFFETEHLLKRYSRSMAIMNNVSLALHRC----C 128

  Fly   113 NTTLHSRALTEILKNPPGYYDVILLEQFNTDCAMSVAHVFQAPVIGMSSCALMPWHY-------E 170
            ...||:.||...|....  :||:|.:..|. |...:|.....|       |:..|.|       :
Human   129 VELLHNEALIRHLNATS--FDVVLTDPVNL-CGAVLAKYLSIP-------AVFFWRYIPCDLDFK 183

  Fly   171 RFGAPLIPSYISALFQGQSQEMSFAGRLGNWITVHSLNLLYKMFTVPAGNALIRQRFGPGLPSTE 235
            ....|...|||..|....|..|:|..|:.|.:...:|:.:...|:.|.. :|..:.|...: |..
Human   184 GTQCPNPSSYIPKLLTTNSDHMTFLQRVKNMLYPLALSYICHTFSAPYA-SLASELFQREV-SVV 246

  Fly   236 DLVRNTSLMLVNQHFSLSGPKPLPPNVIEVGGVHISPPKPLPSDLQKILD-NAPKGVILISWGSQ 299
            |||...|:.|....|.:..|:|:.||::.:||::.:..|||..:.:..:: :...|:::.|.||.
Human   247 DLVSYASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGEHGIVVFSLGSM 311

  Fly   300 LKACSLSAARRDGIVKAIGRLEQEVIWKYENDTLPNKPPNLHIRKWLPQRDILAHPNLKVFMSHG 364
            :.  .:...:...|..|:|::.|.|:|:|......|...|..:.|||||.|:|.||..:.|::|.
Human   312 VS--EIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHA 374

  Fly   365 GLMGTTEAVSSAVPIVGVPIYGDQSLNIAALVQRGMALQLELKKLDENTVYEALTKAL-DPSFKA 428
            |..|..|::.:.||:|.:|::|||..|...:..:|..:.|.:.::....:..||...: |.|:|.
Human   375 GSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKE 439

  Fly   429 RAKEVASSYNNRIQGPLETAIWWVEHVAETKGAPLTQPSAVHLSRFVYYSLDVYSVVALSLLLPV 493
            ....::|.:.:|...||:.|::|||.|...||||..:|:|..|:.:.|:||||     :..||.|
Human   440 NIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDV-----IGFLLAV 499

  Fly   494 ITLLGLI 500
            :..:..|
Human   500 VLTVAFI 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	124/485 (26%)
UGT1A4	NP_009051.1	UDPGT	29..525	CDD:278624	134/514 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150156
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.740