Protein Alignment Ugt36E1 and UGT1A4

DIOPT Version :10

• Sequence 1: NP_609911.1
• Gene: Ugt36E1 / 35139
• FlyBaseID: FBgn0027070
• Length: 517
• Species: Drosophila melanogaster
• Sequence 2: NP_009051.1
• Gene: UGT1A4 / 54657
• HGNCID: 12536
• Length: 534
• Species: Homo sapiens
• Alignment Length: 527
• Identity: 140/527 - (26%)
• Similarity: 239/527 - (45%)
• Gaps: 72/527 - (13%)

  Fly    10 LLALLSLVAFSDSLRILGLFP---HPAISHFKFFHPIMRGLAEAGHSVDVISPFEDKDPPNGYKD 71
            ||.|||:..:::|.::| :.|   .|.:|    ....:|.|...||...|::|..:.
Human    16 LLLLLSVQPWAESGKVL-VVPTDGSPWLS----MREALRELHARGHQAVVLTPEVNM-------- 67

  Fly    72 HLLPPSTLTDTI-----SLEDFER---PYSFLFHYVEFFI----------------LHKMGREDC 112
            |:......|.|.     :.::|:|   .|:..|...|..:                ||:.    |
Human    68 HIKEEKFFTLTAYAVPWTQKEFDRVTLGYTQGFFETEHLLKRYSRSMAIMNNVSLALHRC----C 128

  Fly   113 NTTLHSRALTEILKNPPGYYDVILLEQFNTDCAMSVAHVFQAPVIGMSSCALMPWHY-------E 170
            ...||:.||...|....  :||:|.:..|. |...:|.....|       |:..|.|       :
Human   129 VELLHNEALIRHLNATS--FDVVLTDPVNL-CGAVLAKYLSIP-------AVFFWRYIPCDLDFK 183

  Fly   171 RFGAPLIPSYISALFQGQSQEMSFAGRLGNWITVHSLNLLYKMFTVPAGNALIRQRFGPGLPSTE 235
            ....|...|||..|....|..|:|..|:.|.:...:|:.:...|:.|.. :|..:.|...: |..
Human   184 GTQCPNPSSYIPKLLTTNSDHMTFLQRVKNMLYPLALSYICHTFSAPYA-SLASELFQREV-SVV 246

  Fly   236 DLVRNTSLMLVNQHFSLSGPKPLPPNVIEVGGVHISPPKPLPSDLQKILD-NAPKGVILISWGSQ 299
            |||...|:.|....|.:..|:|:.||::.:||::.:..|||..:.:..:: :...|:::.|.||.
Human   247 DLVSYASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGEHGIVVFSLGSM 311

  Fly   300 LKACSLSAARRDGIVKAIGRLEQEVIWKYENDTLPNKPPNLHIRKWLPQRDILAHPNLKVFMSHG 364
            :.  .:...:...|..|:|::.|.|:|:|......|...|..:.|||||.|:|.||..:.|::|.
Human   312 VS--EIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHA 374

  Fly   365 GLMGTTEAVSSAVPIVGVPIYGDQSLNIAALVQRGMALQLELKKLDENTVYEALTKAL-DPSFKA 428
            |..|..|::.:.||:|.:|::|||..|...:..:|..:.|.:.::....:..||...: |.|:|.
Human   375 GSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKE 439

  Fly   429 RAKEVASSYNNRIQGPLETAIWWVEHVAETKGAPLTQPSAVHLSRFVYYSLDVYSVVALSLLLPV 493
            ....::|.:.:|...||:.|::|||.|...||||..:|:|..|:.:.|:||||     :..||.|
Human   440 NIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDV-----IGFLLAV 499

  Fly   494 ITLLGLI 500
            :..:..|
Human   500 VLTVAFI 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36E1	NP_609911.1	GT1_Gtf-like	23..453	CDD:340817	115/465 (25%)
UGT1A4	NP_009051.1	UDPGT	29..525	CDD:278624	134/514 (26%)