Protein Alignment Ugt36E1 and UGT1A5

DIOPT Version :10

• Sequence 1: NP_609911.1
• Gene: Ugt36E1 / 35139
• FlyBaseID: FBgn0027070
• Length: 517
• Species: Drosophila melanogaster
• Sequence 2: NP_061951.1
• Gene: UGT1A5 / 54579
• HGNCID: 12537
• Length: 534
• Species: Homo sapiens
• Alignment Length: 512
• Identity: 141/512 - (27%)
• Similarity: 239/512 - (46%)
• Gaps: 42/512 - (8%)

  Fly    10 LLALLSLVAFSDSLRILGLFPHPAISHFKFFHPIMRGLAEAGHSVDVISPFEDKDPPNGY--KDH 72
            ||.|||:..:::|.::| :.|... ||:......:|.|...||.|.|::.     ..|.|  :::
Human    16 LLLLLSVQPWAESGKVL-VVPTDG-SHWLSMREALRDLHARGHQVVVLTL-----EVNMYIKEEN 73

  Fly    73 LLPPSTLTDTISLEDFERPYSFLFHYVEFF----ILHKMGR-------------EDCNTTLHSRA 120
            ....:|...:.:.::|:|  ..|.|...||    :|.|..|             ..|...||:.|
Human    74 FFTLTTYAISWTQDEFDR--LLLGHTQSFFETEHLLMKFSRRMAIMNNMSLIIHRSCVELLHNEA 136

  Fly   121 LTEILKNPPGYYDVILLEQFNTDCAMSVAHVFQAPVIGMSSCALMPWHYERFGAPLIPSYISALF 185
            |...|....  :||:|.:.|:. ||..:|.....|.:...........::....|...|||..|.
Human   137 LIRHLHATS--FDVVLTDPFHL-CAAVLAKYLSIPAVFFLRNIPCDLDFKGTQCPNPSSYIPRLL 198

  Fly   186 QGQSQEMSFAGRLGNWITVHSLNLLYKMFTVPAGNALIRQRFGPGLPSTEDLVRNTSLMLVNQHF 250
            ...|..|:|..|:.|.:  :.|.|.|....|.|..|.:.........|..|||.:.|:.|....|
Human   199 TTNSDHMTFLQRVKNML--YPLALSYLCHAVSAPYASLASELFQREVSVVDLVSHASVWLFRGDF 261

  Fly   251 SLSGPKPLPPNVIEVGGVHISPPKPLPSDLQKILD-NAPKGVILISWGSQLKACSLSAARRDGIV 314
            .:..|:|:.||::.:||::.:..|||..:.:..:: :...|:::.|.||.:.  .:...:...|.
Human   262 VMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGEHGIVVFSLGSMVS--EIPEKKAMAIA 324

  Fly   315 KAIGRLEQEVIWKYENDTLPNKPPNLHIRKWLPQRDILAHPNLKVFMSHGGLMGTTEAVSSAVPI 379
            .|:|::.|.|:|:|......|...|..:.|||||.|:|.||..:.|::|.|..|..|::.:.||:
Human   325 DALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPM 389

  Fly   380 VGVPIYGDQSLNIAALVQRGMALQLELKKLDENTVYEALTKAL-DPSFKARAKEVASSYNNRIQG 443
            |.:|::|||..|...:..:|..:.|.:.::....:..||...: |.|:|.....::|.:.:|...
Human   390 VMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVE 454

  Fly   444 PLETAIWWVEHVAETKGAPLTQPSAVHLSRFVYYSLDVYSVVALSLLLPVITLLGLI 500
            ||:.|::|||.|...||||..:|:|..|:.:.|:||||     :..||.|:..:..|
Human   455 PLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDV-----IGFLLAVVLTVAFI 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36E1	NP_609911.1	GT1_Gtf-like	23..453	CDD:340817	116/450 (26%)
UGT1A5	NP_061951.1	UDPGT	29..525	CDD:278624	135/499 (27%)