DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36E1 and UGT1A6

DIOPT Version :9

Sequence 1:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001063.2	Gene:	UGT1A6 / 54578	HGNCID:	12538	Length:	532	Species:	Homo sapiens

Alignment Length:	535	Identity:	135/535 - (25%)
Similarity:	241/535 - (45%)	Gaps:	93/535 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LALLSLVAFSDSLRILGLFPHPAISHFKFFHPIMRGLAEAGHSVDVI------------------ 57
            |||..:|. .|.|.::   |... ||:.....|:..|::.||.:.|:
Human    18 LALWGMVV-GDKLLVV---PQDG-SHWLSMKDIVEVLSDRGHEIVVVVPEVNLLLKESKYYTRKI 77

  Fly    58 --SPFEDKDPPNGYK----DHLLPPSTLTDTISLEDFERPYSFLFHYVEFFILHKMGREDCNTTL 116
              .|::.::..|.|:    :|....|.||         .|.:   .|....|:..:...:|.:.|
Human    78 YPVPYDQEELKNRYQSFGNNHFAERSFLT---------APQT---EYRNNMIVIGLYFINCQSLL 130

  Fly   117 HSRALTEILKNPPGYYDVILLEQFNTDCAMSVAHVFQAPVIGMSS--------CALMPWH-YERF 172
            ..|......|.  ..:|.:.     ||.|:... |..|..:|:.|        |:|.  | :.|.
Human   131 QDRDTLNFFKE--SKFDALF-----TDPALPCG-VILAEYLGLPSVYLFRGFPCSLE--HTFSRS 185

  Fly   173 GAPLIPSYISALFQGQSQEMSFAGRLGNWITVHSLNLL-----YKMFT--VPAGNALIRQRFGPG 230
            ..|:  |||...:...|..|:|:.|:.|::    :|||     |.:|:  ....:|::::
Human   186 PDPV--SYIPRCYTKFSDHMTFSQRVANFL----VNLLEPYLFYCLFSKYEELASAVLKR----- 239

  Fly   231 LPSTEDLV---RNTSLMLVNQHFSLSGPKPLPPNVIEVGGVHISPPKPLPSDLQKILD-NAPKGV 291
               ..|::   :..|:.|:...|.|..|:|:.||::.:||::....|.|..:.:..:: :...|:
Human   240 ---DVDIITLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGGINCKKRKDLSQEFEAYINASGEHGI 301

  Fly   292 ILISWGSQLKACSLSAARRDGIVKAIGRLEQEVIWKYENDTLPNKPPNLHIRKWLPQRDILAHPN 356
            ::.|.||.:.  .:...:...|..|:|::.|.|:|:|......|...|..:.|||||.|:|.||.
Human   302 VVFSLGSMVS--EIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPM 364

  Fly   357 LKVFMSHGGLMGTTEAVSSAVPIVGVPIYGDQSLNIAALVQRGMALQLELKKLDENTVYEALTKA 421
            .:.|::|.|..|..|::.:.||:|.:|::|||..|...:..:|..:.|.:.::....:..||...
Human   365 TRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAV 429

  Fly   422 L-DPSFKARAKEVASSYNNRIQGPLETAIWWVEHVAETKGAPLTQPSAVHLSRFVYYSLDVYSVV 485
            : |.|:|.....::|.:.:|...||:.|::|||.|...||||..:|:|..|:.:.|:||||
Human   430 INDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDV---- 490

  Fly   486 ALSLLLPVITLLGLI 500
             :..||.|:..:..|
Human   491 -IGFLLAVVLTVAFI 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	119/493 (24%)
UGT1A6	NP_001063.2	egt	15..506	CDD:223071	135/535 (25%)
UGT1A6	NP_001063.2	UDPGT	27..523	CDD:278624	131/525 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150165
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.740