DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36E1 and UGT1A8

DIOPT Version :9

Sequence 1:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_061949.3	Gene:	UGT1A8 / 54576	HGNCID:	12540	Length:	530	Species:	Homo sapiens

Alignment Length:	523	Identity:	148/523 - (28%)
Similarity:	244/523 - (46%)	Gaps:	67/523 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LALLSLVAFSDSLRILGLFPHPAISHFKFFHPIMRGLAEAGHSVDVISPFEDKDPPNGYKDHLLP 75
            ::||....|:::.::| :.|... ||:.....::..|...||.|.|:.|  :.....| |.....
Human    14 VSLLLTCGFAEAGKLL-VVPMDG-SHWFTMQSVVEKLILRGHEVVVVMP--EVSWQLG-KSLNCT 73

  Fly    76 PSTLTDTISLEDFERPYS-----------------FLFH---YVEFFILHKMGREDCNTTLHSRA 120
            ..|.:.:.:|||.:|.:.                 ||..   :...|..|      |.:..:.|.
Human    74 VKTYSTSYTLEDLDREFMDFADAQWKAQVRSLFSLFLSSSNGFFNLFFSH------CRSLFNDRK 132

  Fly   121 LTEILKNPPGYYDVILLEQFNTDCAMSVAHVFQAPVIGMS---SCALMPWHYERFGA--PLIPSY 180
            |.|.||.  ..:|.:.|:.|:. |.:.||..|..|.:..:   :|     ||...||  |...||
Human   133 LVEYLKE--SSFDAVFLDPFDA-CGLIVAKYFSLPSVVFARGIAC-----HYLEEGAQCPAPLSY 189

  Fly   181 ISALFQGQSQEMSFAGRLGNWITVHSLNLLYKMFTVPAGNAL-----IRQRFGPGLPSTE-DLVR 239
            :..:..|.|..|:|..|:.|.|.....:|..:.|   :.|||     |.|     .|.|. ||..
Human   190 VPRILLGFSDAMTFKERVRNHIMHLEEHLFCQYF---SKNALEIASEILQ-----TPVTAYDLYS 246

  Fly   240 NTSLMLVNQHFSLSGPKPLPPNVIEVGGVHISPPKPLPSDLQKILD-NAPKGVILISWGSQLKAC 303
            :||:.|:...|.|..|||:.||:|.:||::....||||.:.:..:: :...|:::.|.||.:.
Human   247 HTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIVVFSLGSMVS-- 309

  Fly   304 SLSAARRDGIVKAIGRLEQEVIWKYENDTLPNKPPNLHIRKWLPQRDILAHPNLKVFMSHGGLMG 368
            .:...:...|..|:|::.|.|:|:|......|...|..:.|||||.|:|.||..:.|::|.|..|
Human   310 EIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHG 374

  Fly   369 TTEAVSSAVPIVGVPIYGDQSLNIAALVQRGMALQLELKKLDENTVYEALTKAL-DPSFKARAKE 432
            ..|::.:.||:|.:|::|||..|...:..:|..:.|.:.::....:..||...: |.|:|.....
Human   375 VYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMR 439

  Fly   433 VASSYNNRIQGPLETAIWWVEHVAETKGAPLTQPSAVHLSRFVYYSLDVYSVVALSLLLPVITLL 497
            ::|.:.:|...||:.|::|||.|...||||..:|:|..|:.:.|:||||     :..||.|:..:
Human   440 LSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDV-----IGFLLAVVLTV 499

  Fly   498 GLI 500
            ..|
Human   500 AFI 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	132/481 (27%)
UGT1A8	NP_061949.3	UDPGT	26..521	CDD:278624	145/511 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150116
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.740