DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36E1 and Ugt35D1

DIOPT Version :9

Sequence 1:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	555	Identity:	172/555 - (30%)
Similarity:	277/555 - (49%)	Gaps:	83/555 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VFCLLALLSLVAFSDSLRILGLFPHPAISHFKFFHPIMRGLAEAGHSVDVISPFEDKDPPNGYKD 71
            :|.|:.||.  .:|:..|||.:||.|:.||:.|..|.::.||..||.:..:||:..::|.....|
  Fly     4 IFLLVCLLP--GYSEGARILAVFPLPSSSHYFFALPYLKSLASLGHEITSVSPYPQREPFRNIHD 66

  Fly    72 HLLP------------PSTLTDTISLEDFERPYSFLFHYVEFFILHKMGREDCNTTLHSRAL-TE 123
            ..:|            .||...|....||          :..::|:.     ..|.|::..: .:
  Fly    67 IPVPEVFENFNEVLRIASTPRSTWQSSDF----------INEYVLNL-----TKTVLNNEGVRRD 116

  Fly   124 ILKNPPGYYDVILLEQFNTDCAMSVAHVFQAPVIGMSSCALMPWHYERFGAPLIP-SYI---SAL 184
            ||.....::|:::::.:..|....:|..|.||:|||:|.. ..|..:.....:.| ||:   |:.
  Fly   117 ILGPQKPHFDLVIMDLWRMDVLSGLAAYFDAPIIGMASYG-TDWKIDELMGNVSPISYLQSPSSR 180

  Fly   185 F-----QGQS----QEMSFAGRLGNWITVHSLNLLYKMFTVPAGNALIRQRFGPGLPST------ 234
            |     .|:.    .|.:|:.....|..|.....||..|                .||.
  Fly   181 FYDLEAYGERLLHLMERTFSYMNYKWRHVRKQETLYSQF----------------FPSVAERKPL 229

  Fly   235 EDLVRNTSLMLVNQHFSLSGPKPLPPNVIEVGGVHIS-PPKPLPSDLQKILDNA-PKGVILISWG 297
            .::.||..|:||||||:|..|:|..||:|:|||:|:. ..:.|.::|...:..| ..|||..|.|
  Fly   230 SEISRNFDLVLVNQHFTLGPPRPYVPNMIQVGGLHVDHSTEALSAELDHFIQGAGESGVIYFSLG 294

  Fly   298 SQLKACSLSAARRDGIVKAIGRLEQEVIWKYENDTLPNKPPNLHIRKWLPQRDILAHPNLKVFMS 362
            :.:|:.|||..||..:::....|.|.::||:|::.||.||||:.|.||.||:.||||||:|:|::
  Fly   295 TNVKSKSLSEDRRKVLLETFASLPQRIVWKFEDELLPGKPPNVFISKWFPQQAILAHPNVKLFIT 359

  Fly   363 HGGLMGTTEAVSSAVPIVGVPIYGDQSLNIAALVQRGMALQLELKKLD----ENTVYEALTKALD 423
            ||||:.|.|::....|::|:|...||..|:..:.|.|:.|.|.:|::.    .:|:...||   :
  Fly   360 HGGLLSTIESIHHGKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTSEEFRSTIIRLLT---N 421

  Fly   424 PSFKARAKEVASSYNNRIQGPLETAIWWVEHVAETKGAPLTQPSAVHLSRFVYYSLDVYS---VV 485
            .||:..|:..|:.|.::...|:||||||.|:|...|||...|.:...|....|:||||:.   |.
  Fly   422 KSFEETARITAARYRDQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDVFGTFLVG 486

  Fly   486 ALSLL-----LPVITLLGLIRMFKRREPKGDRKLK 515
            ||.:|     |.|:||...:.:.||.:.:..:|::
  Fly   487 ALVILGIVTYLLVMTLRKCLFLIKRGKCEAIKKIQ 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	151/490 (31%)
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	154/494 (31%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	158/515 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454616
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.890