DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36E1 and Ugt49B2

DIOPT Version :9

Sequence 1:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	529	Identity:	180/529 - (34%)
Similarity:	296/529 - (55%)	Gaps:	27/529 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VFCLLALLSLVAFSDSLRILGLFPHPAISHFKFFHPIMRGLAEAGHSVDVISPF---EDKDPPNG 68
            :|..|..:.|:...|..|||..|..|..|||.....|:|.|.:.||.|..|:|.   ::...||
  Fly     3 LFMKLLFVCLLGTGDGARILAPFFLPVKSHFMMTDAIIRELVKRGHEVTFITPLSLAKENLGPN- 66

  Fly    69 YKDHLLPP-------STLTDTISLEDFERPYSFLFHYVEFFILHKMGREDCNTTLHSRALTEIL- 125
            |::.|||.       |.:..|.|..|. ...|.|.|   ..:...:|.:..:..|....:.|::
  Fly    67 YREILLPKYDTWADISAMMKTKSALDM-IDMSKLTH---MRLAQHIGIKSTDFALAHPEVQELIY 127

  Fly   126 -KNPPGYYDVILLEQFNTDCAMSVAHVFQAPVIGMSSCALMPWHYERFG--APLIPSYISALFQG 187
             |:..|.:|::|:|||:.:.|:.:.::::.|.|.:::.|...:..:.||  .||  ||:..:|..
  Fly   128 AKDKKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYANYFSQVFGFVNPL--SYVPNVFLS 190

  Fly   188 QSQEMSFAGRLGNWITVHSLNLLYKMFTVPAGNALIRQRFG---PGLPSTEDLVRNTSLMLVNQH 249
            .:..||...||.|.:...:.:::.::...|..:|:||:.|.   |.:|:.:.|.:|.|::|:|.:
  Fly   191 CTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVPTVKQLEQNISVILLNSY 255

  Fly   250 FSLSGPKPLPPNVIEVGGVHISPPKPLPSDLQKILDNAPKGVILISWGSQLKACSLSAARRDGIV 314
            ..|:.|:|:..|:|.|||:||.||||||..::..||||..|.|..|.|||:::..:.|.:....:
  Fly   256 MPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYLDNAEHGAIYFSLGSQVRSADMPAEKLQIFL 320

  Fly   315 KAIGRLEQEVIWKYENDTLPNKPPNLHIRKWLPQRDILAHPNLKVFMSHGGLMGTTEAVSSAVPI 379
            .....|:|.|:||:|:|.|||.|.|:.:.|||||.|||||||:|||::||||.|..|||..|||:
  Fly   321 DVFASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQADILAHPNVKVFIAHGGLFGMQEAVYHAVPV 385

  Fly   380 VGVPIYGDQSLNIAALVQRGMALQLELKKLDENTVYEALTKAL-DPSFKARAKEVASSYNNRIQG 443
            :|:|.|.||.:||.|....|.|:.|:.:.:.::.:..||...| ||.::|...:.:..:.:|..|
  Fly   386 LGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLKDPKYQANMMKASRIFRDRPLG 450

  Fly   444 PLETAIWWVEHVAETKGAPLTQPSAVHLSRFVYYSLDVYSVVALSLLLPVITLLGLIRMFKRREP 508
            .::||::|:.:|.|.:|||....:.|||..:.:|.|||.:::....|||::||..:.|.:|  ..
  Fly   451 AMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIILAITLLPLLTLYAVSRNYK--SF 513

  Fly   509 KGDRKLKRK 517
            :|.|..|::
  Fly   514 RGIRAQKKE 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	160/470 (34%)
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	173/505 (34%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	161/472 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454689
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.890