DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36E1 and Ugt35A1

DIOPT Version :9

Sequence 1:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	543	Identity:	168/543 - (30%)
Similarity:	274/543 - (50%)	Gaps:	58/543 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLALLSLVAFS-----DSLRILGLFPHPAISHFKFFHPIMRGLAEAGHSVDVISPF-EDKDPPN- 67
            |:.|:.|.|.:     .|.|||.:||.|..|.:.|....|:.||..||:|.||:.| .||:.||
  Fly    14 LIGLIWLFAANADEGVQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVINTFGSDKNEPNF 78

  Fly    68 ---------------GYKDHLLPPSTLTDTISLEDFERPYSFLFHYVEFFILHKMGREDCNTTLH 117
                           |..|:       |.|.|      .:..|....:|..|       ..|::.
  Fly    79 RVIGAKKIHEIMAAFGNADY-------TQTAS------QWQMLTMTTQFLNL-------LTTSIL 123

  Fly   118 SRALTEILKNPPGYYDVILLEQFNTDCAMSVAHVFQAPVIGMSSCALMPWHYERFGAPLIP-SYI 181
            ..|..:.|.|....:|::::|...|:....:...|.|..||:||.. ...|.:.....:.| ||.
  Fly   124 DDAAVKDLLNSGEKFDLVIMEAVQTEALFGLIQHFGAETIGISSYG-TDTHIDELMGNISPLSYN 187

  Fly   182 SALFQGQSQEMSFAGRLGNWITVHSLNLLYKMFTVPAGNALIRQRFGPGLPSTEDLVRNTSLMLV 246
            ..|...::::|.|..|:.|......:.|..::..:|:...|..:.|.....|.::::.:.:|||:
  Fly   188 PLLLSSRTEQMDFKDRVMNVFEASVMWLHKRIVHLPSQRDLYAKYFPTARKSLDEVLDSFALMLL 252

  Fly   247 NQHFSLSGPKPLPPNVIEVGGVHISPPK---PLPSDLQKILDNAPKGVILISWGSQLKACSLSAA 308
            .||||||.|:|..||:|||||:|:...:   ||..:|.:.::.:.||||..|.||.:|:..|..:
  Fly   253 GQHFSLSYPRPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQSEKGVIYFSMGSNIKSKDLPPS 317

  Fly   309 RRDGIVKAIGRLEQEVIWKYENDTLPNKPPNLHIRKWLPQRDILAHPNLKVFMSHGGLMGTTEAV 373
            .|..:::....:.|.|:||:|:|.||.||.|:.|.||.||.|||||||:|:|::||||:.|.|::
  Fly   318 TRKMLMQTFASVPQRVLWKFEDDQLPEKPDNVFISKWFPQPDILAHPNVKLFITHGGLLSTIESI 382

  Fly   374 SSAVPIVGVPIYGDQSLNIAALVQRGMALQLELKKLDENTVYEALTKAL-DPSFKARAKEVASSY 437
            ....||:|:||:.||.||:....|.|..|..::..::...:...:.:.| :||:.|.|:..:..:
  Fly   383 YFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQELLSNPSYAAAAQTKSKLF 447

  Fly   438 NNRIQGPLETAIWWVEHVAETKGAPLTQPSAVHLSRFVYYSLDVY----SVVALSLLLPVITLLG 498
            .::.:..||.||||.|:|...|||...:.::..|....::.||.:    ::..:|||:.||.:..
  Fly   448 RDQKETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLIAITFVSLLIVVILIKC 512

  Fly   499 LIRMF-----KRREPKGD-RKLK 515
            |.|:|     |.|:.:.: .|||
  Fly   513 LQRVFVSLISKIRKNRAEASKLK 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	149/476 (31%)
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	150/475 (32%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	150/491 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454618
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.890