DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36E1 and Ugt1a7c

DIOPT Version :9

Sequence 1:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_964004.1	Gene:	Ugt1a7c / 394432	MGIID:	3032636	Length:	531	Species:	Mus musculus

Alignment Length:	531	Identity:	142/531 - (26%)
Similarity:	237/531 - (44%)	Gaps:	72/531 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MCGCWKVFCLLALLSLVAFSDSLRILGLFPHPAISHFKFFHPIMRGLAEAGHSVDVISP---FED 62
            :|.|      |.|.|.:|.:..|.::.:..    ||:.....::..|...||.|.|:.|   ::.
Mouse    12 LCVC------LLLASGLAQAGRLLVVPMDG----SHWFTMQTVVEKLLHKGHEVVVVVPEVSWQL 66

  Fly    63 KDPPNGYKDHLLPPSTLTDTISLEDFERPYSFLFH---------------------YVEFFILHK 106
            ..|.|      ....|...:.:.||..|.:.....                     :.|....|
Mouse    67 TKPLN------FVVKTYAVSHTQEDLNREFKIFIDAQWKSQQEGGILPLLDSPAKGFFELLFSH- 124

  Fly   107 MGREDCNTTLHSRALTEILKNPPGYYDVILLEQFNTDCAMSVAHVFQAPVIGMSS---CALMPWH 168
                 |.:..:.:.|.|.||...  :|.:.|:.|:. |.::||..|..|.:..|.   |     |
Mouse   125 -----CRSLFNDKKLVEYLKQTS--FDAVFLDPFDV-CGLTVAKYFSLPSVVFSRGIFC-----H 176

  Fly   169 YERFGA--PLIPSYISALFQGQSQEMSFAGRLGNWIT-VHSLNLLYKMFTVPAGNAL-IRQRFGP 229
            |....|  |..||||..:....:..|:|..|..|.:. :......:|.|...|..|. :.|
Mouse   177 YLEDAAQCPSPPSYIPRMLLKFTDTMTFKERTRNLLAYMGERAFCHKFFKSAADIASEVLQ---- 237

  Fly   230 GLPST-EDLVRNTSLMLVNQHFSLSGPKPLPPNVIEVGGVHISPPKPLPSDLQKILD-NAPKGVI 292
             .|.| .||....|:.|:...|.|..|:|:.||||.:||::....|||..:.:..:: :...|::
Mouse   238 -TPVTMTDLFSPVSIWLLRTDFVLEFPRPVMPNVIYIGGINCHQGKPLSKEFEAYVNASGEHGIV 301

  Fly   293 LISWGSQLKACSLSAARRDGIVKAIGRLEQEVIWKYENDTLPNKPPNLHIRKWLPQRDILAHPNL 357
            :.|.||.:.......|..  |.:|:||:.|.|:|:|......|...|..:.|||||.|:|.||..
Mouse   302 VFSLGSMVSEIPEKKAME--IAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKT 364

  Fly   358 KVFMSHGGLMGTTEAVSSAVPIVGVPIYGDQSLNIAALVQRGMALQLELKKLDENTVYEALTKAL 422
            :.|::|.|..|..|.:.:.||:|.:|::|||..|...:..||..:.|.:.::..:.:..||...:
Mouse   365 RAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVI 429

  Fly   423 -DPSFKARAKEVASSYNNRIQGPLETAIWWVEHVAETKGAPLTQPSAVHLSRFVYYSLDVYSVVA 486
             :.|:|.....::|.:.:|...||:.|::|||:|...||||..:|:|..|:.:.|:||||...:
Mouse   430 NNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFL- 493

  Fly   487 LSLLLPVITLL 497
            |:::|.|:.::
Mouse   494 LAIVLTVVFIV 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	126/490 (26%)
Ugt1a7c	NP_964004.1	UDPGT	26..522	CDD:278624	136/511 (27%)
Ugt1a7c	NP_964004.1	egt	<225..503	CDD:223071	91/285 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840183
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.790