DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36E1 and Ugt49C1

DIOPT Version :9

Sequence 1:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster

Alignment Length:	548	Identity:	167/548 - (30%)
Similarity:	277/548 - (50%)	Gaps:	64/548 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VFCLL---ALLSLVAFSDSLRILGLFPHPAISHFKFFHPIMRGLAEAGHSVDVISPF--EDKDPP 66
            :|.||   .|.|.:..::..:||.::..|..|||.....::|.|.|:||.|.:::.|  |.:...
  Fly     6 LFGLLLTGTLYSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMVTAFSLEKEQLG 70

  Fly    67 NGYKDHLLPPSTLTDTISLEDFERPYSFLFHYVEFFILHKMGRED---------CNTTLHS---- 118
            :.|.:.|:.|        :.||.......|.....|.|.:|...|         ..||.|:
  Fly    71 SNYTEILIEP--------VYDFWHDVKLNFGAQHLFELTRMTNYDFLKMLEIIGLKTTEHALRQP 127

  Fly   119 --RALTEILKNPPGYYDVILLEQFNTDCAMSVAHVFQAPVIGMSSCA-----------LMPWHYE 170
              |:|.. .:...|.:|::|.|||..:..:::||:::.||:..|:..           :.||
  Fly   128 KVRSLIH-AEQKEGVFDLLLAEQFYQEAFLALAHLYKIPVVTTSTLGYENHMSQMMGLITPW--- 188

  Fly   171 RFGAPLIPSYISALFQGQSQEMSFAGRLGNWIT--VHSLNLLYKMFTVPAGNALIRQRFGPGL-- 231
                    |::...|...:..|||..|:.|...  ...::.|...|  |..:|:.|:.|||.|
  Fly   189 --------SFVPHGFMPFTDRMSFLERVKNSYASFYEDMDRLLNYF--PKMDAVAREFFGPVLTE 243

  Fly   232 -PSTEDLVRNTSLMLVNQHFSLSGPKPLPPNVIEVGGVHISPPKPLPSDLQKILDNAPKGVILIS 295
             |..:.:.|..|:||:|.|..|:..:|....::.|||:||.||||||:|:|.:||.|.:|.|..|
  Fly   244 VPKVKHMERQISVMLLNSHAPLTTARPTVDAMVPVGGMHIYPPKPLPADMQALLDGATEGAIFFS 308

  Fly   296 WGSQLKACSLSAARRDGIVKAIGRLEQEVIWKYENDTLPNKPPNLHIRKWLPQRDILAHPNLKVF 360
            .||.:::..:........::..|.|:|.|:||:|::::...|.|:.:||||||.|||||.::|||
  Fly   309 LGSNVQSKDMPVEMLRLFLQVFGSLKQRVLWKFEDESISQLPDNVMVRKWLPQADILAHRHVKVF 373

  Fly   361 MSHGGLMGTTEAVSSAVPIVGVPIYGDQSLNIAALVQRGMALQLELKKLDENTVYEALTKAL-DP 424
            ::||||.||.|.|..|||::|:|.|.||.||:...|..|.|:.|..:.:.|..:..:|.:.: :.
  Fly   374 ITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSITEEILRHSLDQLIHNV 438

  Fly   425 SFKARAKEVASSYNNRIQGPLETAIWWVEHVAETKGAPLTQPSAVHLSRFVYYSLDVYSVVALSL 489
            ::|...:.|:..:.:|...|.::|::|:|:|...:||...:.:.:.|:.|.:|.|||.:.||:..
  Fly   439 TYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRSAGLDLNWFQFYLLDVIAFVAIIA 503

  Fly   490 LLPVITLLGLIRMFKRREPKGDRKLKRK 517
            |..|:.|...||:.     .|..|..||
  Fly   504 LAGVMALSLAIRLL-----MGSNKKHRK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	148/489 (30%)
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	153/503 (30%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	148/482 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454690
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.890