DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36E1 and ugt-35

DIOPT Version :9

Sequence 1:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001023694.1	Gene:	ugt-35 / 3565443	WormBaseID:	WBGene00044286	Length:	536	Species:	Caenorhabditis elegans

Alignment Length:	581	Identity:	136/581 - (23%)
Similarity:	222/581 - (38%)	Gaps:	114/581 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 CWKVFCLLALLSLVAFSDSLRILGLFPHPAISHFKFFHPIMRGLAEAGHSVDVISPFEDKDPPN- 67
            |.|......:..|...|.|:..|...|..|.||..|...|...|:|.||:|..::|...:...|
Worm     3 CRKTILFFLISILFQNSKSVNFLVYCPLFAHSHHTFLAKIADTLSEEGHNVTFLAPIIVQKYENF 67

  Fly    68 GYKDHLLPPSTLTDTISLEDFERPYSFLFHYVEFFILHKMGREDCNTTLHSRALTEILKNPPGYY 132
            .|..|      .||.|.::..|.             |.|:|.     .:.|...::.....|..:
Worm    68 KYLKH------TTDIIYIQPDEE-------------LKKLGE-----IMGSAGFSKYWTEEPSVF 108

  Fly   133 DVI------------LLEQFNTDCAMSV----------AHVFQAPVIGMSSCALMPW-----HYE 170
            .:|            :.|....|  :|:          |.:::  |:..::.|:..:     .|.
Worm   109 SMIPSIKLFQKMFHKIYENLRAD--LSILDSLKDRKFDAMIYE--VLAFNAIAIQQYLGIKTLYP 169

  Fly   171 RF------------GAPLIPSYISALFQGQSQEMSFAGRLGNWITVHSLNLLYKMFTVPAGNALI 223
            .|            |.|..|:.:|:......::|:|..||.|.:..    .:|::|..|
Worm   170 TFSVTHGMVLSKSIGEPASPATLSSALSPYGEKMNFQERLMNTVCA----FIYQVFMKP------ 224

  Fly   224 RQRFGPGLPS---------TEDLVRNTSLMLVNQHFSLSGPKPLPPNVIEVGGVHISP----PKP 275
                 |.:.|         .::.....|.:.:|.:..|..|:|:....:.:||:.::.    .:.
Worm   225 -----PKMISYSHPYYEIDLKEAESKASFVFLNSNPYLDFPRPMLTKTVLIGGISVNTSQIREER 284

  Fly   276 LPSDLQKILDNAPKGVILISWGSQLKACSLSAARRDGIVKAIGRLEQ-EVIWKYENDTL--PNKP 337
            |..:...||:...| .:|||:||.:.:..:....:..|||.|..... ..|||||:|.|  .|..
Worm   285 LSDEYHNILNIRVK-TVLISFGSIMLSTDMPDRYKSIIVKVIEEFPNVTFIWKYESDELDFANNL 348

  Fly   338 PNLHIRKWLPQRDILAHPNLKVFMSHGGLMGTTEAVSSAVPIVGVPIYGDQSLNIAALVQRGMAL 402
            .|||..||:||..:||...|..|::|.||....|......|.:.|||:.||..|...||:...::
Worm   349 KNLHFFKWIPQTALLADSRLSAFITHAGLGSINELSYMGKPAILVPIFADQLRNAKMLVRHNGSI 413

  Fly   403 QLELKKLDENTVYEALTKAL-----DPSFKARAKEVASSYNNRIQGPLETAIWWVEHVAETKGAP 462
            .||.:.|..   :|.|..:|     |.||:..|:.:|...||:...|.|..|......||....|
Worm   414 SLEKQDLGN---FEKLRVSLAKILKDNSFQENAEILARQLNNQPISPRELLIKHATFGAEFGELP 475

  Fly   463 LTQPSAVHLSRFVYYSLDVYSVVALSLLLPVITLLGLIRMF------KRREPKGDRKLKRK 517
            ...|.:..:|.|....:|::..:.:.|.:.|..|...:|:.      |:...|.....|.|
Worm   476 SLDPYSRQMSFFSLNMIDIFLFLGVFLAILVYFLFTFLRLLLNLLLKKKAVEKSQENRKTK 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	123/516 (24%)
ugt-35	NP_001023694.1	Glycosyltransferase_GTB_type	2..464	CDD:299143	121/507 (24%)
ugt-35	NP_001023694.1	UDPGT	34..506	CDD:278624	121/518 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161420
Domainoid	1	1.000	172	1.000	Domainoid score	I2232
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.740