DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36E1 and Ugt2b10

DIOPT Version :9

Sequence 1:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001178605.1	Gene:	Ugt2b10 / 305264	RGDID:	1309989	Length:	532	Species:	Rattus norvegicus

Alignment Length:	554	Identity:	152/554 - (27%)
Similarity:	263/554 - (47%)	Gaps:	77/554 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLALLSLVAFSDS---LRILGLFPHPAISHFKFFHPIMRGLAEAGHSVDVISP-----FEDKDPP 66
            ||.||.|..|..|   .::| ::| ...||:.....|:..|.:.||.|.|:.|     :|..:
  Rat    10 LLLLLQLSDFFGSGTGGKVL-VWP-MEFSHWLNLRVILDELLKKGHEVTVLRPSASLSYEVDN-- 70

  Fly    67 NGYKDHLLPPSTLTDTISLEDFERPYSFLFHYVEFF------ILHKMGRED-------------- 111
                         |..|..|.:...|| |....|||      .::::.::.
  Rat    71 -------------TSAIEFETYPTSYS-LTEVDEFFWESLRKYIYELPKQSFWGYFLMFQELVWV 121

  Fly   112 --------CNTTLHSRALTEILKNPPGYYDVILLEQFNTDCAMSVAHVFQAPVIGMSSCALMPWH 168
                    |...:.::.|...|:|  ..:||||.:.| ..|...:|.:.:.|::  .|....|..
  Rat   122 DSDYFESLCKDVVFNKELMTKLQN--SGFDVILADPF-IPCGDLLAEILKIPLV--YSLRFFPGS 181

  Fly   169 -YERF--GAPLIPSYISALFQGQSQEMSFAGRLGNWITVHSLNLLYKMFTVPAGNALIRQRFGPG 230
             ||::  |.|:.|||:.......|..|:|..|:.:.|.|...:..::.|.....|.|..:..  |
  Rat   182 TYEKYSGGLPMPPSYVPIAMSELSDRMTFVERMKHMIYVLCFDFWFQAFNEKKWNELYTEVL--G 244

  Fly   231 LPST-EDLVRNTSLMLVNQHFSLSGPKPLPPNVIEVGGVHISPPKPLPSDLQKILDNAPK-GVIL 293
            .|:| .:.:....:.|:..::.|..|.|:.||...|||:|..|.||||.:::..:.::.: ||::
  Rat   245 RPTTLSETMAKADIWLIRTYWDLEFPHPVLPNFDFVGGLHCRPAKPLPKEIEDFVQSSGEHGVVV 309

  Fly   294 ISWGSQLKACSLSAARRDGIVKAIGRLEQEVIWKYENDTLPNKPPNLHIRKWLPQRDILAHPNLK 358
            .|.||.:.  :|:..|.:.|...:.::.|:|:|::|.........|..:.||:||.|:|.||..:
  Rat   310 FSLGSMVG--NLTEERANVIAAGLAQIPQKVLWRFEGKKPETLGSNTRLYKWIPQNDLLGHPKTR 372

  Fly   359 VFMSHGGLMGTTEAVSSAVPIVGVPIYGDQSLNIAALVQRGMALQLELKKLDENTVYEAL-TKAL 422
            .|::|||..|..||:...:|:||:|::|||..||..|..:|.|::|:...:....::.|| |...
  Rat   373 AFITHGGTNGIYEAIYHGIPVVGIPLFGDQYDNIVHLKTKGAAVRLDFLTMSSTDLFTALKTITN 437

  Fly   423 DPSFKARAKEVASSYNNRIQGPLETAIWWVEHVAETKGAPLTQPSAVHLSRFVYYSLDVYSVVAL 487
            |||:|..|..::..::::...||:.|::|:|.|...|||...:.:|..||...|:||||...
  Rat   438 DPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWVQYHSLDVIGF--- 499

  Fly   488 SLLLPVITLLGLIR---MF-KRREPKGDRKLKRK 517
             ||..|:|::.:::   :| .::..|..||.||:
  Rat   500 -LLACVVTVMFILKKCCLFCCQKFTKAGRKKKRE 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	131/491 (27%)
Ugt2b10	NP_001178605.1	UDPGT	26..529	CDD:278624	142/533 (27%)
Ugt2b10	NP_001178605.1	egt	35..510	CDD:223071	137/503 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343993
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930