DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36E1 and Ugt1a8

DIOPT Version :9

Sequence 1:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_787040.2	Gene:	Ugt1a8 / 301595	RGDID:	708474	Length:	530	Species:	Rattus norvegicus

Alignment Length:	532	Identity:	141/532 - (26%)
Similarity:	240/532 - (45%)	Gaps:	70/532 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GCWKVFCLLALLSLVA-FSDSLRILGLFPHPAISHFKFFHPIMRGLAEAGHSVDVISP------- 59
            ||.....|...|.|.: |:.:.|:| :.|... ||:.....|:..|:..||.|.|:.|
  Rat     5 GCPPSLPLCVCLFLASGFAQAGRLL-VVPMDG-SHWFTMQMIVEKLSHRGHEVVVVIPEVSWHMG 67

  Fly    60 ----FEDKDPPNGYKDHLLPPSTLTDTISLEDFERPYSFLFH-------YVEFFILHKMGR---- 109
                |..|              |.:.:.:|||....:.|..|       ...|.:|...|:
  Rat    68 KSLNFTVK--------------TYSVSYTLEDLNYHFKFFAHNQWKTQEVGMFSLLKHSGKGFFE 118

  Fly   110 ---EDCNTTLHSRALTEILKNPPGYYDVILLEQFNTDCAMSVAHVFQAPVIGMSS---CALMPWH 168
               ..|.:....:.|.|.||.  ..:|.:.|:.|:. |.:.:|..|..|.:..|.   |     |
  Rat   119 LLFSHCRSLFKDKKLVEYLKQ--SSFDAVFLDPFDV-CGLILAKYFSLPSVVFSGGIFC-----H 175

  Fly   169 YERFGA--PLIPSYISALFQGQSQEMSFAGRLGNWITVHSLNLLYKMF---TVPAGNALIRQRFG 228
            |...||  |..|||:..:....:..|:|..|:.|.::..........|   .|...:.:::
  Rat   176 YLDEGAQCPSPPSYVPRILSKFTDTMTFKERVWNHLSYMKERAFCPYFFKTAVEIASEVLQ---- 236

  Fly   229 PGLPST-EDLVRNTSLMLVNQHFSLSGPKPLPPNVIEVGGVHISPPKPLPSDLQKILD-NAPKGV 291
              .|.| .||....|:.:....|.|..|:|:.||::.:||::....|||..:.:..:: :...|:
  Rat   237 --TPVTMRDLFSPVSIWMFRTDFVLEFPRPVMPNMVYIGGINCHQGKPLSKEFEAYVNASGEHGI 299

  Fly   292 ILISWGSQLKACSLSAARRDGIVKAIGRLEQEVIWKYENDTLPNKPPNLHIRKWLPQRDILAHPN 356
            ::.|.||.:.......|..  |.:|:||:.|.|:|:|......|...|..:.|||||.|:|.||.
  Rat   300 VVFSLGSMVSEIPEKKAME--IAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPK 362

  Fly   357 LKVFMSHGGLMGTTEAVSSAVPIVGVPIYGDQSLNIAALVQRGMALQLELKKLDENTVYEALTKA 421
            .:.|::|.|..|..|.:.:.||:|.:|::|||..|...:..||..:.|.:.::..:.:..||...
  Rat   363 ARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTV 427

  Fly   422 L-DPSFKARAKEVASSYNNRIQGPLETAIWWVEHVAETKGAPLTQPSAVHLSRFVYYSLDVYSVV 485
            : :.|:|.....::|.:.:|...||:.|::|||:|...||||..:|:|..|:.:.|:||||...:
  Rat   428 INNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFL 492

  Fly   486 ALSLLLPVITLL 497
             |:::|.|:.::
  Rat   493 -LAIVLTVVFIV 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	126/493 (26%)
Ugt1a8	NP_787040.2	UDPGT	26..521	CDD:278624	135/511 (26%)
Ugt1a8	NP_787040.2	egt	<263..504	CDD:223071	76/244 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810