DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36E1 and Ugt2b36

DIOPT Version :9

Sequence 1:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001025038.1	Gene:	Ugt2b36 / 231396	MGIID:	3576103	Length:	530	Species:	Mus musculus

Alignment Length:	539	Identity:	153/539 - (28%)
Similarity:	262/539 - (48%)	Gaps:	49/539 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 WKVFCLLALLSLVAFSDSLRILGLFPHPA-ISHFKFFHPIMRGLAEAGHSVDVISP----FEDKD 64
            ||....|.||.:.....|.:...:...|. .||:.....|:..|.:.||.|.|:.|    |.|..
Mouse     3 WKWISALLLLQISCCFRSAKCGKVLVWPVDYSHWMNIKIILDELKQKGHEVTVLRPSTSIFLDPK 67

  Fly    65 PPNGYKDHLLPPSTLTDTISL--------EDFERP------YSFLF-----HYVEFFILHKMGRE 110
            ...|.|....|.|...|.:.:        ..:|.|      ||.|.     .|.::.:..
Mouse    68 KSPGLKFETFPTSFSNDVMEIIFAKAVERWTYEVPRDTCLSYSPLLQNIFDEYSDYCLTL----- 127

  Fly   111 DCNTTLHSRALTEILKNPPGYYDVILLEQFNTDCAMSVAHVFQAPVIGMSSCALMPWHY-ERF-- 172
             |..|:.::.|  :.|.....:||||.:... .|...:|.:.|.|.  :.|....|.:| |::
Mouse   128 -CKDTVSNKQL--MAKLQESKFDVILSDAIG-PCGELIAELLQIPF--LYSLRFSPGYYLEKYSG 186

  Fly   173 GAPLIPSYISALFQGQSQEMSFAGRLGNWITVHSLNLLYKMFTVPAGNALIRQRFGPGLPST-ED 236
            |.||.|||:..:..|.|.:|:|..|:.|.|.:...:..::.|.....:....:..  |.|:| .:
Mouse   187 GLPLPPSYVPVILSGLSGQMTFKERVKNMICMLYFDFWFQTFREKKWDQFYSETL--GRPTTLIE 249

  Fly   237 LVRNTSLMLVNQHFSLSGPKPLPPNVIEVGGVHISPPKPLPSDLQKILDNAPK-GVILISWGSQL 300
            .:....:.|:..::.|..|.|..|||..|||||..|.||||.:::..:.::.: ||::.|.||.:
Mouse   250 TMGKAEMWLIRSYWDLEFPHPTLPNVYYVGGVHCKPAKPLPKEMEDFVQSSGEHGVVVFSLGSMV 314

  Fly   301 KACSLSAARRDGIVKAIGRLEQEVIWKYENDTLPNKPPNLHIRKWLPQRDILAHPNLKVFMSHGG 365
            .  :::..:.:.|..|:.::.|:|:|:::..|.....||..|.|||||.|:|.||..|.|::|||
Mouse   315 S--NMTEEKANAIAWALAQIPQKVLWRFDGKTPATLGPNTRIYKWLPQNDLLGHPKTKAFITHGG 377

  Fly   366 LMGTTEAVSSAVPIVGVPIYGDQSLNIAALVQRGMALQLELKKLDENTVYEALTKALD-PSFKAR 429
            ..|..||:...:|::|:|::|:|..|||.:|.:|.|:.|.::.:..:.:..||.:.:| |.:|..
Mouse   378 ANGLYEAIHHGIPMIGIPLFGEQHDNIAHMVAKGAAVTLNIRTMSRSDLLNALEEVIDNPFYKEN 442

  Fly   430 AKEVASSYNNRIQGPLETAIWWVEHVAETKGAPLTQPSAVHLSRFVYYSLDV----YSVVALSLL 490
            |..:::.::::...||:.|::|:|.|...|||...:|.|.:|:.:.|:||||    .:.|...:.
Mouse   443 AMWLSTIHHDQPMKPLDRAVFWIEFVMRHKGAKHLRPLAYNLTWYQYHSLDVIGFLLAFVTFIVA 507

  Fly   491 LPVITLLGLIRMFKRREPK 509
            |.|...|.:.|.|.::|.|
Mouse   508 LIVKCFLFVYRFFVKKEKK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	134/484 (28%)
Ugt2b36	NP_001025038.1	egt	8..506	CDD:223071	144/512 (28%)
Ugt2b36	NP_001025038.1	UDPGT	24..527	CDD:278624	147/518 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840144
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.790