DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36E1 and ugt-54

DIOPT Version :9

Sequence 1:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_501996.2	Gene:	ugt-54 / 188885	WormBaseID:	WBGene00012013	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	553	Identity:	153/553 - (27%)
Similarity:	239/553 - (43%)	Gaps:	86/553 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLALLSLVAFSDSLRILGLFPHPAISHFKFFHPIMRGLAEAGHSVDVISP--------------- 59
            ||..|.|..|::.|.||......|.||..|.:..::.|.:.||:||::..
Worm     4 LLGFLILPGFANCLNILFYVSVIAQSHIPFHNTAIKVLLDRGHTVDLVIAQLNEMVKLKFPNGVG 68

  Fly    60 ------FEDKDPPNGYKDHLLPPSTLTDTISLEDFERPYSFLFHYVEFFILHKMGREDCNTTLHS 118
                  :||   ||.|:.:   ...|:|..    .|:|...    .||.....|....|.|.:..
Worm    69 KNYTFGYED---PNFYRKN---AGHLSDIF----VEKPIPM----AEFLTFDDMTFNLCETVVKD 119

  Fly   119 RALTEILKNPPGYYDVILLEQFNTDCAMSVAHVFQAPVIGMSSCALMPWHYERFGAPLI-PSYIS 182
            ..|...:|.  |.||:.|...:: .||..:.|....|    |..:::|       .||. |..:|
Worm   120 PNLLNYIKQ--GNYDIGLSSDYD-PCANILMHAGGVP----SKASMVP-------TPLFQPQIVS 170

  Fly   183 ALFQGQSQ----------EMSFAGRLGNWITVHSLNLLYKMFTVP----AGNALIRQRFGPGLPS 233
            |.....:.          :.||..||.:.|. |:.|:   .|..|    ..|.|:.:.|||..||
Worm   171 AGLPSPASVYGTVLYPKGDDSFFNRLFHLIR-HTYNI---YFVAPRLMEKYNNLLLETFGPTFPS 231

  Fly   234 TEDLVRNTSLMLVNQHFSLSGPKPLPPNVIEVGGVHISPPKPLPSDLQKILDNAPKGVILISWGS 298
            .|::.||..::|||.:..:..|:|:...:..:||:.....:||..:...||..:.|||:|.|:|:
Worm   232 AEEIERNVDIILVNSNEIIEKPRPVSHKIKYIGGMGKKKAQPLNKEFNDILATSNKGVVLFSFGT 296

  Fly   299 QLKACSLSAARRDGIVKAIGRL-EQEVIWKYENDT----LPNKPPNLHIRKWLPQRDILAHPNLK 358
            |:....:....|...|.|.... :...:|||:|.|    |.....|:|..:||||.|:|....:|
Worm   297 QVATSKVPIEIRKNFVTAFKHFPDFSFLWKYDNLTDDAELFADSSNIHRVEWLPQTDLLGDNRVK 361

  Fly   359 VFMSHGGLMGTTEAVSSAVPIVGVPIYGDQSLNIAALVQRGMALQLELKKLDENTVYEALTKAL- 422
            .|:||.||....|..::.:|::.||::.||..|....|.|.:.:.:|..:|....:..||.|.|
Worm   362 AFISHMGLNSFLETSAAGIPVLAVPLFIDQQHNALNAVSRDIGVIVERHQLTVENLVNALQKLLY 426

  Fly   423 DPSFKARAKEVASSYNNRIQGPLETAIWWVEHVAETKGAP--LTQPSAVHLSRFVYYSLDVYSVV 485
            :|.:...||.::...|.:.:......:.|||:.|:..|..  :..|.| .|:.|.|||:||..:|
Worm   427 NPKYGENAKMISKMMNEKPEQSERLFVDWVEYAAKNPGLHKIMNLPGA-ELTPFWYYSVDVILIV 490

  Fly   486 ALSLLLPVI----TLLGL-----IRMFKRREPK 509
            .|||...:|    ||..:     ||..:..|||
Worm   491 VLSLTSSLIIIWKTLSFIKCQISIRSVRSIEPK 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	131/491 (27%)
ugt-54	NP_501996.2	UDPGT	35..507	CDD:278624	136/504 (27%)
ugt-54	NP_501996.2	egt	<218..498	CDD:223071	88/280 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R17030
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840