DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt36E1 and ugt-25

DIOPT Version :9

Sequence 1:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_491438.1	Gene:	ugt-25 / 172087	WormBaseID:	WBGene00015692	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	532	Identity:	133/532 - (25%)
Similarity:	233/532 - (43%)	Gaps:	57/532 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VFCLLALLSLVAFSDSLRILGLFPHPAISHFKFFHPIMRGLAEAGHSVDVISPFED--------- 62
            ||.||:::::.||:    ||...|....||..|...:...|.||||:|..:.|..|
Worm     6 VFILLSVINVNAFN----ILVYSPSFGGSHTNFMARLADTLTEAGHNVTFVVPVADEARKGQLGV 66

  Fly    63 ---KDPPNGYKDHLLPPSTLTDTISLEDFERPY-----------SFLFHYVEFFILHKMGREDCN 113
               ||.....:|.|:.    ::...|:|....|           |....:.:..:|      .||
Worm    67 KKTKDVVIVEQDELMK----SEIKPLDDDMAQYWETDMDSSNADSIFSVFSDAMLL------SCN 121

  Fly   114 TTLHSRALTEILKNPPGYYDVILLEQFNTDCAMSVAHVFQA-PVIGMSSCALMPWHYERFGAPLI 177
            ..:.::.:...||:  ..:||.:.|..:. |.:...|.... .:|..|||||........|.|:.
Worm   122 NFMRNKKVFNELKS--RNFDVGIYEPLSV-CGLGYMHAIGINKLIMSSSCALYDGTVAAIGEPID 183

  Fly   178 PSYISALFQGQSQEMSFAGRLGNW-ITVHSLNLLYKMFTVPAGNALIRQRFGPGLPSTEDLVRNT 241
            .||:........::||...:|.|: :::.|..:.|..:  .....:.::..|..:|...||:.::
Worm   184 FSYVPGSMSKSGEKMSLFEKLENYRLSMASSRMQYGQW--DKETEIYKKHLGNDIPHWRDLMPSS 246

  Fly   242 SLMLVNQHFSLSGPKPLPPNVIEVGGVHIS----PPKPLPSDLQKILDNAPKGVILISWGSQLKA 302
            |:...|....:..|:.:....:.:||:.:.    ..:.|..:...:||..|.. :|||:||.:::
Worm   247 SVAFTNSIPYVDFPRSITQKTVPIGGISVDMEMIKSQKLSIEWSTVLDERPHN-MLISFGSMVRS 310

  Fly   303 CSLSAARRDGIVKAIGRLEQEV--IWKYENDTL--PNKPPNLHIRKWLPQRDILAHPNLKVFMSH 363
            ..:....|:|:::|| :.|..|  |||||||.|  .....|::..||:||..:|....|..||:|
Worm   311 MDMPLKWRNGLLEAI-KSEPNVTFIWKYENDNLEWAKGIQNIYFSKWVPQTALLNDARLTAFMTH 374

  Fly   364 GGLMGTTEAVSSAVPIVGVPIYGDQSLNIAALVQRGMALQLELKKLDE-NTVYEALTKAL-DPSF 426
            |||..|.|......|.:.||::.||..|...|.:.|..|.:..|:|.. .|:..::...| :..:
Worm   375 GGLGSTNELAFLGKPALMVPVFADQDRNANMLARHGGVLVVHKKELGNFKTIKSSIRSILHEEKY 439

  Fly   427 KARAKEVASSYNNRIQGPLETAIWWVEHVAETKGAPLTQPSAVHLSRFVYYSLDVYSVVALSLLL 491
            :..|::::...||:...|.|..:.:.|.||:....|........|.......:|:|:.::||.|.
Worm   440 QKNARKLSELLNNQPLKPKEQVVKYTEFVAKFGPFPQMDSYGRQLGFIQRNLIDIYAAISLSYLF 504

  Fly   492 PVITLLGLIRMF 503
             ||:|:..:..|
Worm   505 -VISLIYFVFKF 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	122/487 (25%)
ugt-25	NP_491438.1	egt	1..477	CDD:223071	123/491 (25%)
ugt-25	NP_491438.1	UDPGT	29..530	CDD:278624	124/505 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	172	1.000	Domainoid score	I2232
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.860