DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt36E1 and ugt-26

DIOPT Version :9

Sequence 1:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_491435.2	Gene:	ugt-26 / 172085	WormBaseID:	WBGene00015695	Length:	529	Species:	Caenorhabditis elegans

Alignment Length:	533	Identity:	150/533 - (28%)
Similarity:	240/533 - (45%)	Gaps:	67/533 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VFCLLALLSLVAFSDSLRILGLFPHPAISHFKFFHPIMRGLAEAGHSVDVISP--FEDKDPPNGY 69
            |.|.|:|:|      ||.||...|..|.||..|...:...|.||||:|..:.|  .|::....|.
Worm    12 VLCTLSLVS------SLNILVHSPAYAASHTNFMARLADTLTEAGHNVTFLVPIALEERRDKLGV 70

  Fly    70 KDHLLPPSTLT-DTISLEDFERPYSFLFHY---VEFFILHKMGRED---------------CNTT 115
            |        || |.|.:|..|...|.|..:   :||..:.:|....               |...
Worm    71 K--------LTKDVIIVEQDEEMKSKLVPHSGSIEFLWIIEMDSSSIDAMFSWYNEIMILTCENF 127

  Fly   116 LHSRALTEILKNPPGYYDVILLEQFNTDCAMSVAHVFQ-APVIGMSSCALMPWHYE----RFGAP 175
            :.::.:...||:  .::||.:.|.| |.|.:.:..... ...|.:||||    ||:    ..|.|
Worm   128 MRNKQVMSELKS--RHFDVAIAEPF-TICGLGLFEELNIKKTILVSSCA----HYDFMLPHIGEP 185

  Fly   176 LIPSYISALFQGQSQEMSFAGRLGNW-ITVHSLNLLYKMFTVPAGNALIRQRFGPGLPSTEDLVR 239
            ...|.:..|.....:|||...:..|: :...:...|.|:|  .|...:.|:.||..:|..::|:.
Worm   186 EDFSSVPTLSSKVGEEMSMTEKWENYRLVAETKASLAKLF--DAETRIYRESFGSDIPDWKELMS 248

  Fly   240 NTSLMLVNQHFSLSGPKPLPPNVIEVGGVHIS----PPKPLPSDLQKILDNAPKGVILISWGSQL 300
            :.||...|.:..:..|:......|.:||:.:.    ..:.|..:.:::|:...|. :|||:||.:
Worm   249 SASLYFTNSNPFIDYPRASIQKTISIGGITVDFQQIKSEKLNKEWEEVLNKRQKS-MLISFGSNV 312

  Fly   301 KACSLSAARRDGIVKAIGRLEQ-EVIWKYEND--TLPNKPPNLHIRKWLPQRDILAHPNLKVFMS 362
            .:..:.||.:.||.:.|..:.. ..|||||:|  :..:...|:|..||:||..:|..|.|..|::
Worm   313 PSDKMPAAWKAGIFETIKSMPNVTFIWKYESDDVSFADGISNIHFSKWVPQTALLNDPRLSAFLT 377

  Fly   363 HGGLMGTTEAVSSAVPIVGVPIYGDQSLNIAALVQRGMALQLELKKLD-----ENTVYEALTKAL 422
            ||||..|.|....|.|.|.|||||||:.|...|.:.|..:.|..|:|.     :..|::.|   .
Worm   378 HGGLGSTNELAYCAKPAVMVPIYGDQTRNANMLARHGSVIVLHKKELANVQRVKKAVHDIL---Y 439

  Fly   423 DPSFKARAKEVASSYNNRIQGPLETAIWWVEHVAETKGAPLTQPSAVHLSRFVYYSLDVYSVVAL 487
            :..:...|:.:|....|:.:.|.||.:.:.|.||:....|...|....|:.|....||:||:.||
Worm   440 NKQYTESAERIAEMIKNQPKTPKETVVRYTEFVAKYGPFPQMAPHGRKLTYFQKTFLDIYSLFAL 504

  Fly   488 SLLLPVITLLGLI 500
            . ::.|:|:..|:
Worm   505 G-VVSVLTVAFLV 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	137/491 (28%)
ugt-26	NP_491435.2	egt	4..481	CDD:223071	138/495 (28%)
ugt-26	NP_491435.2	UDPGT	34..525	CDD:278624	139/505 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161460
Domainoid	1	1.000	172	1.000	Domainoid score	I2232
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14289
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.790