DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36E1 and Ugt1a6

DIOPT Version :9

Sequence 1:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001034780.1	Gene:	Ugt1a6 / 113992	RGDID:	620949	Length:	530	Species:	Rattus norvegicus

Alignment Length:	539	Identity:	138/539 - (25%)
Similarity:	231/539 - (42%)	Gaps:	88/539 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 CLLALLSLVA-----------FSDSLRILGLFPHPAISHFKFFHPIMRGLAEAGHSVDVISP--- 59
            |||....|.|           ..|.|.::   |... ||:.....|:..|:|.||.:.|:.|
  Rat     3 CLLPAARLPAGFLFLVLWGSVLGDKLLVV---PQDG-SHWLSMKEIVEHLSERGHDIVVLVPEVN 63

  Fly    60 --------FEDKDPPNGYKDHLLPPSTLTDTISLEDFERPY-SF--------------LFHYVEF 101
                    :..|..|..|              :||:....| ||              |..|...
  Rat    64 LLLGESKYYRRKSFPVPY--------------NLEELRTRYRSFGNNHFAASSPLMAPLREYRNN 114

  Fly   102 FILHKMGREDCNTTLHSRALTEILKNPPGYYDVILLEQFNTD----CAMSVAHVFQAPVIGM--- 159
            .|:..|....|.:.|...|....|:.  ..:|.:.     ||    |.:.:|...:.|.:.:
  Rat   115 MIVIDMCFFSCQSLLKDSATLSFLRE--NQFDALF-----TDPAMPCGVILAEYLKLPSVYLFRG 172

  Fly   160 SSCALMPWHYERFGAPLIPSYISALFQGQSQEMSFAGRLGNWIT----VHSLNLLYKMFTVPAGN 220
            ..|:|   .:....:|...||:...:...|..|:|..||.|:|.    .:..:.||..:.:.|.:
  Rat   173 FPCSL---EHMLGQSPSPVSYVPRFYTKFSDHMTFPQRLANFIANILENYLYHCLYSKYEILASD 234

  Fly   221 ALIRQRFGPGLPSTEDLVRNTSLMLVNQHFSLSGPKPLPPNVIEVGGVHISPPKPLPSDLQKILD 285
            .|.|....|.|       ...||.|:...|....|:|:.||:|.:||.:......|..:.:..::
  Rat   235 LLKRDVSLPAL-------HQNSLWLLRYDFVFEYPRPVMPNMIFIGGTNCKKKGNLSQEFEAYVN 292

  Fly   286 -NAPKGVILISWGSQLKACSLSAARRDGIVKAIGRLEQEVIWKYENDTLPNKPPNLHIRKWLPQR 349
             :...|:::.|.||.:.......|..  |.:|:||:.|.|:|:|......|...|..:.|||||.
  Rat   293 ASGEHGIVVFSLGSMVSEIPEKKAME--IAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQN 355

  Fly   350 DILAHPNLKVFMSHGGLMGTTEAVSSAVPIVGVPIYGDQSLNIAALVQRGMALQLELKKLDENTV 414
            |:|.||..:.|::|.|..|..|.:.:.||:|.:|::|||..|...:..||..:.|.:.::..:.:
  Rat   356 DLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDL 420

  Fly   415 YEALTKAL-DPSFKARAKEVASSYNNRIQGPLETAIWWVEHVAETKGAPLTQPSAVHLSRFVYYS 478
            ..||...: :.|:|.....::|.:.:|...||:.|::|||:|...||||..:|:|..|:.:.|:|
  Rat   421 ENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHS 485

  Fly   479 LDVYSVVALSLLLPVITLL 497
            |||...: |:::|.|:.::
  Rat   486 LDVIGFL-LAIVLTVVFIV 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	123/500 (25%)
Ugt1a6	NP_001034780.1	egt	14..504	CDD:223071	133/528 (25%)
Ugt1a6	NP_001034780.1	UDPGT	26..521	CDD:278624	133/516 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810