DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36E1 and Ugt3a1

DIOPT Version :9

Sequence 1:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_997099.2	Gene:	Ugt3a1 / 105887	MGIID:	2146055	Length:	523	Species:	Mus musculus

Alignment Length:	556	Identity:	147/556 - (26%)
Similarity:	250/556 - (44%)	Gaps:	92/556 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FCLLALLSLVAFSDSLRILGLFPHPAISHFKFFHPIMRGLAEAGHSVDVIS-PFEDKDPPNGYKD 71
            |.||.:|.|    ::.:||.:....| ||:...:.:.:.|...||  |||. .:|..|.|:..|:
Mouse    12 FFLLEVLLL----EAAKILTISTLSA-SHYILMNRVSQILQGGGH--DVIKLLYEGGDIPDFRKE 69

  Fly    72 H--------LLPPSTLTDTISLEDFERPYSFLFH------------YVEFFILHKMGREDCNTTL 116
            :        .||          ||.::.:...:|            |.....:|:...:.|:..|
Mouse    70 NSSYQVINWRLP----------EDQQKTFENRWHRLIDEYAYGRSKYHTLLKIHQYFADLCSHLL 124

  Fly   117 HSRALTEILKNPPGYYDVILLEQFNTDCAMSVAHVFQAPVIGMSSCALMPWH--YERFGAPLIP- 178
            ..:.:.|:|:..  .:|::||:..:. |:..:..     .:|....:.:|:.  |..||.|..|
Mouse   125 SRKDIMELLQKE--NFDLVLLDSMDL-CSFLIVE-----KLGKRFVSFLPFQFSYMDFGLPNAPL 181

  Fly   179 SYISALFQGQSQEMSFAGRLGNWITVHSLNLLYKMFTVPA-------GNALIRQRFGPG-LPSTE 235
            ||......|.:.:|.|.||:.|       .|::..||...       ||. :::.|..| .|...
Mouse   182 SYAPVYGSGLTDQMDFWGRVKN-------ILMFFHFTKKRRDIFSQYGNT-VQEHFAEGSQPVLS 238

  Fly   236 DLVRNTSLMLVNQHFSLSGPKPLPPNVIEVGGVHISPPKPLPSDLQKILDN-APKGVILISWGSQ 299
            ||:....|..||..|:|...:||.||.:.|||:...|.:|:|.||:..:.. ...|.:|::.||
Mouse   239 DLLLKAELWFVNSDFALDFARPLFPNTVYVGGLLDKPVQPIPQDLEDFISQFGDSGFVLVALGS- 302

  Fly   300 LKACSLSAARRDGIVK----AIGRLEQEVIWKYENDTLP---NKPPNLHIRKWLPQRDILAHPNL 357
                .:|..:...|:|    |...|.|.|:|..::...|   :..||:.|..||||.|:||||::
Mouse   303 ----VVSMIQSKEIIKEMNSAFAHLPQGVLWTCKSSHWPKDVSLAPNVKIMDWLPQIDLLAHPSI 363

  Fly   358 KVFMSHGGLMGTTEAVSSAVPIVGVPIYGDQSLNIAALVQRGMALQLELKKLDENTVYEALTKAL 422
            ::|::|||:....|||...||:||:|.:|||..|:..:..:.:.:.::|:.|...:....:.:.:
Mouse   364 RLFVTHGGMNSVMEAVHHGVPMVGIPFFGDQPENMVRVEAKNLGVSIQLQTLKAESFLLTMKEVI 428

  Fly   423 -DPSFKARA---KEVASSYNNRIQGPLETA---IWWVEHVAETKGAPLTQPSAVHLSRFVYYSLD 480
             |..:|..|   |.:..|:      ||..|   :.|::|:.:|.||...:|.|........|.||
Mouse   429 EDQRYKTAAMASKVIRQSH------PLTPAQRLVGWIDHILQTGGAAHLKPYAFQQPWHEQYMLD 487

  Fly   481 VYSVVALSLLLPVITLLGLIRMFKRREPKGDRKLKR 516
            |: :..|.|.|..:.|...:.:...|.....||:|:
Mouse   488 VF-LFLLGLTLGTLWLSVKVLVAVTRYLSISRKVKQ 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	131/498 (26%)
Ugt3a1	NP_997099.2	UDPGT	24..488	CDD:278624	132/503 (26%)
Ugt3a1	NP_997099.2	egt	<235..488	CDD:223071	80/263 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840167
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740