DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36E1 and Ugt2b34

DIOPT Version :9

Sequence 1:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_705826.1	Gene:	Ugt2b34 / 100727	MGIID:	2140962	Length:	532	Species:	Mus musculus

Alignment Length:	539	Identity:	154/539 - (28%)
Similarity:	267/539 - (49%)	Gaps:	51/539 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLALLSLVAFSDS---LRILGLFPHPAISHFKFFHPIMRGLAEAGHSVDVISPFE----DKDPPN 67
            ||.||.|..|..|   .::| ::| ...||:.....|:..|.:.||.|.|:.|..    :.|..:
Mouse    10 LLLLLQLSGFFGSGTGGKVL-VWP-MEFSHWLNLKTILDELLKKGHEVMVLRPSASLSYEVDNTS 72

  Fly    68 GYKDHLLPPS-TLTDTISLED----------FERPYSFLFHYVEFFILHKMGRED-------CNT 114
            ..:....|.| :|::   ||:          :|.|....:.|  |.:|.:|...|       |..
Mouse    73 AIEFETYPTSYSLSE---LEEIFWESLKKYIYELPKQSFWGY--FLMLQEMVWVDSKYFESLCKD 132

  Fly   115 TLHSRAL-TEILKNPPGYYDVILLEQFNTDCAMSVAHVFQAPVIGMSSCALMPWH-YERF--GAP 175
            .:.::.| |::.|:   .:||||.:.| ..|...:|.|.:.|::  .|....|.. ||::  |.|
Mouse   133 VVFNKELMTKLQKS---RFDVILADPF-IPCGDLLAEVLKIPLV--YSLRFFPGSTYEKYSGGLP 191

  Fly   176 LIPSYISALFQGQSQEMSFAGRLGNWITVHSLNLLYKMFTVPAGNALIRQRFGPGLPST-EDLVR 239
            |.|||:..:....|..|:|..|:.|.|.:...:..::.|.....|.|..:..  |.|:| .:.:.
Mouse   192 LPPSYVPVVMSELSDRMTFMERVRNVIYMLCFDFWFQTFNEKNWNQLYTEVL--GRPTTLSETMA 254

  Fly   240 NTSLMLVNQHFSLSGPKPLPPNVIEVGGVHISPPKPLPSDLQKILDNAPK-GVILISWGSQLKAC 303
            ...:.|:..::.|..|.|:.||...:||:|..|.||||.:::..:.::.: ||::.|.||.:.
Mouse   255 KADIWLIRTYWDLEFPHPVLPNFDFIGGLHCRPAKPLPKEIEDFVQSSGEHGVVVFSLGSMVG-- 317

  Fly   304 SLSAARRDGIVKAIGRLEQEVIWKYENDTLPNKPPNLHIRKWLPQRDILAHPNLKVFMSHGGLMG 368
            |::..|.:.|...:.::.|:|:|::|.........|..:.||:||.|:|.|...:.|::|||..|
Mouse   318 SITEERANVIAAGLAQIPQKVLWRFEGKKPETLGSNTRLYKWIPQNDLLGHSKTRAFITHGGTNG 382

  Fly   369 TTEAVSSAVPIVGVPIYGDQSLNIAALVQRGMALQLELKKLDENTVYEAL-TKALDPSFKARAKE 432
            ..||:...:|:||:|::|||..||..|..:|.|::|:...:....::.|| |...|||:|..|..
Mouse   383 IYEAIYHGIPVVGIPLFGDQYDNIVHLKAKGAAVRLDFLTMSSTDLHTALKTVTNDPSYKENAMR 447

  Fly   433 VASSYNNRIQGPLETAIWWVEHVAETKGAPLTQPSAVHLSRFVYYSLDVYSVVALSLLLPVITLL 497
            ::..::::...||:.|::|:|.|...|||...:.:|..||...|:||||...: |:.:|.|:.:|
Mouse   448 LSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWVQYHSLDVLGFL-LACVLTVMFIL 511

  Fly   498 GLIRMF-KRREPKGDRKLK 515
            ....:| .::..|..||.|
Mouse   512 KKCCLFCCQKLTKAGRKKK 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	134/481 (28%)
Ugt2b34	NP_705826.1	UDPGT	27..529	CDD:278624	145/519 (28%)
Ugt2b34	NP_705826.1	egt	<272..510	CDD:223071	79/240 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840143
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.790