DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36E1 and Ugt2b38

DIOPT Version :9

Sequence 1:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_598655.1	Gene:	Ugt2b38 / 100559	MGIID:	2140794	Length:	530	Species:	Mus musculus

Alignment Length:	548	Identity:	149/548 - (27%)
Similarity:	259/548 - (47%)	Gaps:	61/548 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MCGCWKVFCLLALLSLVAFSDSLRILGLFPHP-AISHFKFFHPIMRGLAEAGHSVDVISP----- 59
            |.|.|  ...|.||.:.....|::...:...| ..||:.....|:..|.:.||.|.|:.|
Mouse     1 MPGKW--ISALLLLQISCCFRSVKCGKVLVWPMEFSHWMNIKIILDELVQRGHEVTVLRPSAYYV 63

  Fly    60 FEDKDPPNGYKDHLLPPSTLTDTISLEDFERPYSFLFHYVEFFILHKMGREDCNTTLHSRALTEI 124
            .:.|..| |.|....|.|...|.:.        :|...:|:.: .::|.|:.|.:  :|..|..:
Mouse    64 LDPKKSP-GLKFETFPTSVSKDNLE--------NFFIKFVDVW-TYEMPRDTCLS--YSPLLQNM 116

  Fly   125 LKNPPGYY-----DV----------------ILLEQFNTDCAMSVAHVFQAPVIGMSSCALMPWH 168
            :.....|:     ||                :||......|...:|.:.|.|.  :.|....|.:
Mouse   117 IDEFSDYFLSLCKDVVSNKELMTKLQESKFDVLLSDPVASCGELIAELLQIPF--LYSIRFSPGY 179

  Fly   169 Y-----ERFGAPLIPSYISALFQGQSQEMSFAGRLGNWITVHSLNLLYKMFTVPAGNALIRQRFG 228
            .     .||..|  |||:..:..|...:|:|..|:.|.|.....:..::||.....::...:..
Mouse   180 QIEKSSGRFLLP--PSYVPVILSGLGGQMTFIERVKNMICRLYFDFWFQMFNDKKWDSFYSEYL- 241

  Fly   229 PGLPST-EDLVRNTSLMLVNQHFSLSGPKPLPPNVIEVGGVHISPPKPLPSDLQKILDNA-PKGV 291
             |.|:| .:.:....:.|:..::.|..|.|..|||..|||:|..|.||||.|:::.:.:: ..||
Mouse   242 -GRPTTLAETMGKAEMWLIRSNWDLEFPHPTLPNVDYVGGLHCKPAKPLPKDMEEFVQSSGDHGV 305

  Fly   292 ILISWGSQLKACSLSAARRDGIVKAIGRLEQEVIWKYENDTLPNKPPNLHIRKWLPQRDILAHPN 356
            ::.|.||.:.  :::..:.:.|..|:.::.|:|:||::..|......|..:.|||||.|:|.||.
Mouse   306 VVFSLGSMVS--NMTEEKANTIAWALAQIPQKVLWKFDGKTPATLGHNTRVYKWLPQNDLLGHPK 368

  Fly   357 LKVFMSHGGLMGTTEAVSSAVPIVGVPIYGDQSLNIAALVQRGMALQLELKKLDENTVYEALTKA 421
            .|.|::|||..|..|.:...:|::|:|::|:|..|||.:|.:|.|:.|.::.:..:.|..||.:.
Mouse   369 TKAFVTHGGANGVYEVIYHGIPMIGIPLFGEQHDNIAHMVAKGAAVTLNIRTMSRSDVLNALEEV 433

  Fly   422 LD-PSFKARAKEVASSYNNRIQGPLETAIWWVEHVAETKGAPLTQPSAVHLSRFVYYSLDV---- 481
            :| |.:|..|..:::.::::...||:.|::|||.|...|.|...:....:|:...|:.|||
Mouse   434 IDNPFYKKNAIWLSTIHHDQPTKPLDRAVFWVEFVMRHKRAKHLRSLGHNLTWHQYHFLDVIGFL 498

  Fly   482 YSVVALSLLLPVITLLGLIRMFKRREPK 509
            .|.||::::|.|..||.:.|.|.::|.|
Mouse   499 LSCVAVTIVLTVKCLLFIYRFFVKKEKK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	130/491 (26%)
Ugt2b38	NP_598655.1	egt	8..506	CDD:223071	138/517 (27%)
Ugt2b38	NP_598655.1	UDPGT	24..526	CDD:278624	141/521 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840147
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.790