DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt36E1 and ugt5b2

DIOPT Version :9

Sequence 1:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001170970.2	Gene:	ugt5b2 / 100415799	ZFINID:	ZDB-GENE-100406-4	Length:	531	Species:	Danio rerio

Alignment Length:	554	Identity:	142/554 - (25%)
Similarity:	247/554 - (44%)	Gaps:	73/554 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 WKVFCLLALLSLVAFSDSLRILGLFPHPAISHFKFFHPIMRGLAEAGHSVDVISPFEDKDPPNGY 69
            |.: .|..||..|..:...::| :||... ||:...:.::..|:..||.|.|:     :...:.|
Zfish    10 WPI-TLTLLLPSVPVAQCGKVL-VFPVDG-SHWVNMNILVEALSAKGHDVTVM-----RTASSCY 66

  Fly    70 KDHLLPPSTLTDTISL--------EDFERPYSFLFH-----------------YVEFFILHKMGR 109
            .....|..|   :|:|        |..|:..|.:.|                 :..|..:.:..|
Zfish    67 IKEFSPHYT---SINLKSKGGYNKEVLEQFASRIMHILRDGSTWGHLKLQADMWQSFLKIFEAER 128

  Fly   110 EDCNTTLHSRALTEILKNPPGYYDVILLEQFNTDCAMSVAHVFQAPVI------GMSSCALMPWH 168
            |.....:..:.|.:.||:  ..||:||.:. |....:.:.|..:.|::      |.:..     |
Zfish   129 EMIVNMIEDQQLMQSLKD--AKYDLILTDP-NMFGGVILGHYLKLPMVYNVRWAGYNEA-----H 185

  Fly   169 YERFGAPLIPSYISALFQGQSQEMSFAGRLGNWITVHSLNLLYKMFTVPAGNALIRQRFGPGLPS 233
            :....:||  ||:.......|..|||..|:.|.:....:.:...:...|..:||..:..||| .|
Zfish   186 FSIAPSPL--SYVPMPSLELSDRMSFLQRVYNVVMYIFIEIGAALVISPINDALAERFIGPG-TS 247

  Fly   234 TEDLVRNTSLMLVNQHFSLSGPKPLPPNVIEVGGVHISPPKPLPSDLQKILDNA-PKGVILISWG 297
            ...||:...|.|....|....|:|..||||.:.|....|.||||.||:..:.:: ..|||::|.|
Zfish   248 FLSLVQGADLWLHRVDFVFEYPRPTMPNVIYMAGFQCKPSKPLPQDLEDFVQSSGDHGVIIMSLG 312

  Fly   298 SQLKACSLSAARRDGIVKAIGRLEQEVIWKYE--------NDTLPNKPPNLHIRKWLPQRDILAH 354
            :.:.......|  :.|.:|...|.|::||:|:        |:||        |..|:||.|:|.|
Zfish   313 TLIDKLPDDVA--EAIAEAFAELPQKIIWRYKGKRPSALGNNTL--------IMDWMPQNDLLGH 367

  Fly   355 PNLKVFMSHGGLMGTTEAVSSAVPIVGVPIYGDQSLNIAALVQRGMALQLELKKLDENTVYEALT 419
            |..:.|::|||..|..||:...|||:|..:..||..|::.:..||.|..::...:::.:....:.
Zfish   368 PKTRAFVAHGGTNGIQEAIYHGVPIIGFGLIFDQPDNLSKMRVRGAAKNVDFATMNKESFLTTVK 432

  Fly   420 KAL-DPSFKARAKEVASSYNNRIQGPLETAIWWVEHVAETKGAPLTQPSAVHLSRFVYYSLDVYS 483
            :.| |||::...:.::..:.:....||:.||:|:|.|...|||...:..:..:..:.|:|:||..
Zfish   433 EVLYDPSYRENMQRLSRLHKDVPVKPLDNAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVIL 497

  Fly   484 VVALSLLLPVITLLGLIRMFKRREPKGDRKLKRK 517
            |:..::.|.::::..:||.|..|......|:|.:
Zfish   498 VLISAVSLIILSIYAVIRYFCCRICMRKTKIKHE 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	127/495 (26%)
ugt5b2	NP_001170970.2	egt	12..501	CDD:223071	134/520 (26%)
ugt5b2	NP_001170970.2	UDPGT	27..525	CDD:278624	135/528 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584293
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.740