DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt36E1 and ugt5b3

DIOPT Version :9

Sequence 1:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001348442.1	Gene:	ugt5b3 / 100415792	ZFINID:	ZDB-GENE-100406-5	Length:	534	Species:	Danio rerio

Alignment Length:	543	Identity:	140/543 - (25%)
Similarity:	243/543 - (44%)	Gaps:	79/543 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 WKVFCLLALLSLVAFSDSLRILGLFPHPAISHFKFFHPIMRGLAEAGHSVDVISPFEDKDPPNGY 69
            |.| .|..||..|...:|..:| :|| ..:||:...:.::..|...||::.|:     :...:.|
Zfish    10 WPV-TLTLLLVTVPVVESGNVL-VFP-VDVSHWVNMNVLVEALHAKGHNITVM-----RMADSWY 66

  Fly    70 KDHLLPPSTLTDTIS----LEDFERPY-SFLFHY-------------VEFF----ILHKMGREDC 112
            .....|..|..:..|    .|||..|: |.|.:.             :|.:    .:.::.||..
Zfish    67 IKEFSPHYTSVNLKSSGGLSEDFIGPFVSRLMNILREGSTWGRLKLEIEMWQTSLKMIEIEREMI 131

  Fly   113 NTTLHSRALTEILKNPPGYYDVILLEQFNTDCAM----SVAHVFQAPVI--------GMSSCALM 165
            ...:..:.|.:.||.  ..:|:||     ||.||    .:.|..:.|::        |....|:.
Zfish   132 TNMIEDQQLMQSLKK--AKFDLIL-----TDPAMYGGVMLGHYLKLPIVYNVRWTIFGEGHFAIA 189

  Fly   166 PWHYERFGAPLIPSYISALFQGQSQEMSFAGRLGNWITVHSLNLLYKMFTVPAGNALIRQRFGPG 230
            |       :||  ||:..........|||..|:.|.:..............|..|||..:..||.
Zfish   190 P-------SPL--SYVPVPMLEIPDRMSFLERVKNVVMYIITETQIAFLIAPTYNALCERFIGPE 245

  Fly   231 LPSTEDLVRNTSLMLVNQHFSLSGPKPLPPNVIEVGGVHISPPKPLPSDLQKILDNA-PKGVILI 294
            : :..:||:...|.|....|....|:|..||::.:.|....|.||||.||:..:.:: ..|||::
Zfish   246 V-NFGNLVQEADLWLHRADFVFEYPRPTMPNIVYMAGFQCKPSKPLPQDLEDFVQSSGDHGVIVM 309

  Fly   295 SWGSQLKACSLSAARRDGIVKAIGRLEQEVIWKYE--------NDTLPNKPPNLHIRKWLPQRDI 351
            |.|:.:.......|  :.|.:|...|.|::||:|:        |:||        :..|:||.|:
Zfish   310 SLGTLIGQLPDDVA--EAIAEAFAELPQKIIWRYKGKRPSALGNNTL--------VMDWMPQNDL 364

  Fly   352 LAHPNLKVFMSHGGLMGTTEAVSSAVPIVGVPIYGDQSLNIAALVQRGMALQLELKKLDENTVYE 416
            |.||..:.|::|||..|..||:...|||:|..:..||..|::.:..||.|..::...:|:.:..:
Zfish   365 LGHPKTRAFVAHGGTNGVQEAIYHGVPIIGFGLIFDQPDNLSKMRVRGAAKNVDFATMDKESFLK 429

  Fly   417 ALTKAL-DPSFKARAKEVASSYNNRIQGPLETAIWWVEHVAETKGAPLTQPSAVHLSRFVYYSLD 480
            .:.:.| |||::...:.::..:.:....||:.||:|:|.|...|||...:..:..:..:.|:|:|
Zfish   430 TVKEVLYDPSYRENMQRLSRLHKDVPVKPLDNAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVD 494

  Fly   481 VYSVVALSLLLPVITLLGLIRMF 503
            |..|:..::.|.::::..:||.|
Zfish   495 VILVLISAVSLIILSIYAVIRYF 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	128/498 (26%)
ugt5b3	NP_001348442.1	UDPGT	27..531	CDD:278624	133/525 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584291
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.740