DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36D1 and Ugt1a6a

DIOPT Version :9

Sequence 1:	NP_001246082.2	Gene:	Ugt36D1 / 35138	FlyBaseID:	FBgn0032713	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_659545.2	Gene:	Ugt1a6a / 94284	MGIID:	2137698	Length:	531	Species:	Mus musculus

Alignment Length:	549	Identity:	152/549 - (27%)
Similarity:	252/549 - (45%)	Gaps:	76/549 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LFLALALSQPDELVEAAGPLKVLG----LFPHPGVSHFHFFHPIMKGLAEAGHDVSVVSHFPDKH 69
            |||.|..|             |||    :.|..| ||:.....|::.|:|.|||:.|:  .|:.:
Mouse    16 LFLVLWAS-------------VLGDKLLVVPQDG-SHWLSMKEIVEHLSERGHDIMVL--VPEVN 64

  Fly    70 PVAHYKDFPLTGMDKLTNSVDLKFFEKRTF-YSHF----------QEF---FLLYDWGKQTCNLT 120
            .:.....:....:..:|.|::......||| .:||          :|:   .::.|.....|...
Mouse    65 LLLGESKYYRRKIFSVTYSLEELQTRFRTFGNNHFLPGASLMGPLREYRNNMIVVDMFFSNCQSL 129

  Fly   121 LRSEALQQILRRPGRFDVIIMEQFNTD----CMMGVAHQLQAPVIALSSCVMMPWHYERM--GAP 179
            |:..|....||. .:||.:.     ||    |.:.:|..|..|.:.|..  ..|...|.|  .:|
Mouse   130 LKDSATLSFLRE-NKFDALF-----TDPAMPCGVILAEYLNLPSVYLFR--GFPCSLEHMLGQSP 186

  Fly   180 LIPSHIPALFMAQSQHMNFGGRLANWFSTHALNWMYKLL----SVPAADAMVQYKFGHDVPSVGE 240
            ...|::|..:...|.||.|..||||:......|::|..|    .:.|:|.:   |....:||:.:
Mouse   187 SPVSYVPRFYTKFSDHMTFPQRLANFIVNILENYLYYCLYSKYEIIASDLL---KRDVSLPSLHQ 248

  Fly   241 LVKNTSMFFVNQHYSLSGPKVTPPNVIELGGIHIQKSKPLPADLQRILD-NAEEGVILISWGSMI 304
                .|::.:...:....|:...||:|.||||:.:|...|..:.:..:: :.|.|:::.|.|||:
Mouse   249 ----NSLWLLRYDFVFEYPRPVMPNMIFLGGINCKKKGKLTQEFEAYVNASGEHGIVVFSLGSMV 309

  Fly   305 RANSLSAAKRDGIIRAVARLKQKVIWKWENETLPNQPPNMHIMKWLPQRDILCHPNVKVFMSHGG 369
              :.:...|...|..|:.|:.|.|:|::......|...|..::|||||.|:|.||..:.|::|.|
Mouse   310 --SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSG 372

  Fly   370 LMGTSEAAYCGVPVVATPMYGDQFVNTAALVERGMGTILNFEDIGENTVMRALKKALDKKFHDAA 434
            ..|..|....|||:|..|::|||..|...:..||.|..||..::..:.:..|||..::.|.:...
Mouse   373 SHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKEN 437

  Fly   435 KVVSHSFH-HRPQQALHTAIWWVEHVAHTGGAPLLKPSAVEMSRFVYYSLDVYAVLALVLGSIIA 498
            .:...|.| .||.:.|..|::|||:|....|||.|:|:|.:::.:.|:||||...|.    :|:.
Mouse   438 IMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLL----AIVL 498

  Fly   499 SWVWLLRLCC---------GSSAAQKTKK 518
            :.|:::..||         |....:|:.|
Mouse   499 TVVFIVFKCCAYGCRKCFGGKGRVKKSHK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	135/490 (28%)
Ugt1a6a	NP_659545.2	egt	15..503	CDD:223071	147/523 (28%)
Ugt1a6a	NP_659545.2	UDPGT	27..522	CDD:278624	142/518 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840181
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.740