DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36D1 and Ugt2b35

DIOPT Version :9

Sequence 1:	NP_001246082.2	Gene:	Ugt36D1 / 35138	FlyBaseID:	FBgn0032713	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001004271.1	Gene:	Ugt2b35 / 83808	RGDID:	620895	Length:	530	Species:	Rattus norvegicus

Alignment Length:	501	Identity:	140/501 - (27%)
Similarity:	235/501 - (46%)	Gaps:	87/501 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 SHFHFFHPIMKGLAEAGHDVSVV----SHFPDKHPVAHYKDFPLTGMDKLTNSVDLKFFEKRT-F 99
            ||:.....|::.|.:.||:|:|:    |.|.|....:                 ||||....| |
  Rat    34 SHWMNIKIILEELVQKGHEVTVLRPSASVFLDPKETS-----------------DLKFVTFPTSF 81

  Fly   100 YSH-FQEFFL------LYDWGKQTC-----------------NLTLRSEAL--QQILRR--PGRF 136
            .|| .:.||.      .|:..:.||                 .||:..||:  :|.:.:  ..:|
  Rat    82 SSHDLENFFTRFVNVWTYELPRDTCLSYFLYLQDTIDEYSDYCLTVCKEAVSNKQFMTKLQESKF 146

  Fly   137 DVIIMEQFNTDCMMGVAHQLQAPVIALSSCVMMPWH--YERMGAPLI-PSHIPALFMAQSQHMNF 198
            ||:..:... .|...:|..||.|.  |.|....|.:  .:.:|..|. ||::|.:|...:..|.|
  Rat   147 DVVFSDAIG-PCGELIAELLQIPF--LYSLRFSPGYTIEKYIGGVLFPPSYVPMIFSGLAGQMTF 208

  Fly   199 GGRLAN---------WFST-HALNW--MY-KLLSVPAADAMVQYKFGHDVPSVGELVKNTSMFFV 250
            ..|:.|         ||.| ....|  .| |.|..|.              ::.|::....|:.:
  Rat   209 IERVHNMICMLYFDFWFQTFREKKWDPFYSKTLGRPT--------------TLAEIMGKAEMWLI 259

  Fly   251 NQHYSLSGPKVTPPNVIELGGIHIQKSKPLPADLQRILDNA-EEGVILISWGSMIRANSLSAAKR 314
            ..::.|..|....|||..:||:|.:.:||||.|::..:.:: |.||::.|.|||:|  :::..|.
  Rat   260 RSYWDLEFPHPISPNVDYIGGLHCKPAKPLPKDIEDFVQSSGEHGVVVFSLGSMVR--NMTEEKA 322

  Fly   315 DGIIRAVARLKQKVIWKWENETLPNQPPNMHIMKWLPQRDILCHPNVKVFMSHGGLMGTSEAAYC 379
            :.|..|:|::.|||:|:::.:..|...||..:.|||||.|:|.||..|.|::|||..|..||.:.
  Rat   323 NIIAWALAQIPQKVLWRFDGKKPPTLGPNTRLYKWLPQNDLLGHPKTKAFVTHGGANGIYEAIHH 387

  Fly   380 GVPVVATPMYGDQFVNTAALVERGMGTILNFEDIGENTVMRALKKALDKKFHDAAKVVSHSFHH- 443
            |:|::..|::|:|..|.|.:|.:|....:||..:.::.::.||::.::..|:....:...:.||
  Rat   388 GIPMIGIPLFGEQHDNIAHMVAKGAAVEVNFRTMSKSDMLNALEEVINNPFYKKNAMWLSTIHHD 452

  Fly   444 RPQQALHTAIWWVEHVAHTGGAPLLKPSAVEMSRFVYYSLDVYAVL 489
            :|.:.|..|::|:|.|....||..|:.....:..:.|:||||...|
  Rat   453 QPTKPLDRAVFWIEFVMRHKGAKHLRSLGHNLPWYQYHSLDVIGFL 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	135/492 (27%)
Ugt2b35	NP_001004271.1	UDPGT	24..527	CDD:278624	140/501 (28%)
Ugt2b35	NP_001004271.1	egt	<270..489	CDD:223071	72/220 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343987
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.740