DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36D1 and UGT2A3

DIOPT Version :9

Sequence 1:	NP_001246082.2	Gene:	Ugt36D1 / 35138	FlyBaseID:	FBgn0032713	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	XP_011530549.1	Gene:	UGT2A3 / 79799	HGNCID:	28528	Length:	533	Species:	Homo sapiens

Alignment Length:	568	Identity:	148/568 - (26%)
Similarity:	261/568 - (45%)	Gaps:	90/568 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWSPRVALLFLALALSQPDELVEAAGPLKVLGLFPHPGVSHFHFFHPIMKGLAEAGHDVSVVSHF 65
            |.|.:.||:||.|.|.    .|......||| ::| ..:||:.....|::.|...||:|:|::|
Human     1 MRSDKSALVFLLLQLF----CVGCGFCGKVL-VWP-CDMSHWLNVKVILEELIVRGHEVTVLTH- 58

  Fly    66 PDKHPVAHYK-----DFPLTGM--DKLTNS---VDLKFFEKRTFYSHFQEFFLLYDWG------- 113
             .|..:..|:     .|.:..|  |:...:   |||. .......|.:|....|.|:.
Human    59 -SKPSLIDYRKPSALKFEVVHMPQDRTEENEIFVDLA-LNVLPGLSTWQSVIKLNDFFVEIRGTL 121

  Fly   114 KQTCNLTLRSEALQQILRRPGRFDVIIMEQFNTDCMMGVAHQLQAP-VIAL---------SSCVM 168
            |..|...:.::.|.:.|:.. .:||::::.. ..|...:|..|..| |:.|         .||..
Human   122 KMMCESFIYNQTLMKKLQET-NYDVMLIDPV-IPCGDLMAELLAVPFVLTLRISVGGNMERSCGK 184

  Fly   169 MPWHYERMGAPLIPSHIPALFMAQSQHMNFGGRLAN---------W---FSTHALNWMY-KLLSV 220
            :|       |||  |::|......:..|.|..|:.|         |   :..|.....| |.|..
Human   185 LP-------APL--SYVPVPMTGLTDRMTFLERVKNSMLSVLFHFWIQDYDYHFWEEFYSKALGR 240

  Fly   221 PAADAMVQYKFGHDVPSVGELVKNTSMFFVNQHYSLSGPKVTPPNVIELGGIHIQKSKPLP---- 281
            |.              ::.|.|....::.:..::....|:...||...:||:|.:.:|.||
Human   241 PT--------------TLCETVGKAEIWLIRTYWDFEFPQPYQPNFEFVGGLHCKPAKALPKINF 291

  Fly   282 --ADLQRILDNA-EEGVILISWGSMIRANSLSAAKRDGIIRAVARLKQKVIWKWENETLPNQPPN 343
              .:::..:.:: |:|:::.|.||:.:  :::..|.:.|..|:|::.|||:|:::.:.......|
Human   292 YLQEMENFVQSSGEDGIVVFSLGSLFQ--NVTEEKANIIASALAQIPQKVLWRYKGKKPSTLGAN 354

  Fly   344 MHIMKWLPQRDILCHPNVKVFMSHGGLMGTSEAAYCGVPVVATPMYGDQFVNTAALVERGMGTIL 408
            ..:..|:||.|:|.||..|.|::|||:.|..||.|.|||:|..|::|||..|.|.:..:|....:
Human   355 TRLYDWIPQNDLLGHPKTKAFITHGGMNGIYEAIYHGVPMVGVPIFGDQLDNIAHMKAKGAAVEI 419

  Fly   409 NFEDIGENTVMRALKKAL-DKKFHDAAKVVSHSFHHRPQQALHTAIWWVEHVAHTGGAPLLKPSA 472
            ||:.:....::|||:..: |..:.:.|..:|...|.:|.:.|..|::|:|.|....||..|:.:|
Human   420 NFKTMTSEDLLRALRTVITDSSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRSAA 484

  Fly   473 VEMSRFVYYSLDVYAVLALVLGSIIASWVWLLRLCCGSSAAQ--KTKK 518
            .:::.|.:||:||...|.    :.:|:.::|...|...|..:  ||:|
Human   485 HDLTWFQHYSIDVIGFLL----ACVATAIFLFTKCFLFSCQKFNKTRK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	128/508 (25%)
UGT2A3	XP_011530549.1	UDPGT	24..528	CDD:278624	138/539 (26%)
UGT2A3	XP_011530549.1	egt	<267..498	CDD:223071	72/232 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150096
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.740