DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36D1 and ugt2a6

DIOPT Version :9

Sequence 1:	NP_001246082.2	Gene:	Ugt36D1 / 35138	FlyBaseID:	FBgn0032713	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001138283.1	Gene:	ugt2a6 / 797211	ZFINID:	ZDB-GENE-081104-3	Length:	529	Species:	Danio rerio

Alignment Length:	566	Identity:	151/566 - (26%)
Similarity:	255/566 - (45%)	Gaps:	103/566 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WSPRVALLFLALALSQPDELVEAAGPLKVLGLFPHPG-VSHFHFFHPIMKGLAEAGHDVSVV--S 63
            ||.||.::                           || .||:|...|:::.|.:..|.|:|:  |
Zfish    19 WSGRVLVM---------------------------PGEYSHWHNMRPVIEALVDKNHSVTVLVGS 56

  Fly    64 HFPDKHPVAHYKDFPLTGMDKLTNSVDLKFFEKRT---FYSHFQEFFLLYDWGKQTCNL---TLR 122
            ..|         ..|.|..::....|.....||..   .:.||.|.     |..:|.:.   ||.
Zfish    57 SSP---------TVPHTQKERFEYHVFKVNMEKEVVDYLWIHFHEL-----WMNETISTYEKTLE 107

  Fly   123 SEALQQILRR------PGRFDVIIMEQF---NTDCMMG---------VAHQLQAPVIALSSCVMM 169
            ...|..:.|.      .|.|||.:::..   |.|.:..         :|.:|..|.: ||..:..
Zfish   108 VWQLMSLFRAHSEELVKGLFDVGLLKTLRDSNYDVLFSDLTMPFSDLMAQKLNIPHV-LSMRISF 171

  Fly   170 PWHYERM--GAPLIPSHIPALFMAQ---SQHMNFGGRLANW--FSTHALNWMYKLLSVPAADAMV 227
            ....||:  ..|:..|::||. :||   :..|:|..|:.|.  :.||..  |::|.:
Zfish   172 ASALERLCGQMPVPQSYVPAA-VAQGHLTDRMSFTERVENMLLYITHTA--MFQLTT-------- 225

  Fly   228 QYKFGH-------DVPSVGELVKNTSMFFVNQHYSLSGPKVTPPNVIELGGIHIQKSKPLPADLQ 285
            ::.|.|       :..::.|.:..|.::.:..::....|:..|||...:||:..:.:|||..:|:
Zfish   226 KFTFDHIYAEISGEPTTMCETIGKTDIWLIRTYWDFEYPRPFPPNFKFVGGLQCKPAKPLAKELE 290

  Fly   286 RILDNA-EEGVILISWGSMIRANSLSAAKRDGIIRAVARLKQKVIWKWENETLPNQPPNMHIMKW 349
            ..:.:: :.|:::.|.||||:  :|:..|.:.|..|:.::.|||:|::..:|.....||..|..|
Zfish   291 EFVQSSGDHGIVVFSLGSMIK--NLTVQKANTIAAALGQISQKVVWRYSGKTPETLAPNTKIYDW 353

  Fly   350 LPQRDILCHPNVKVFMSHGGLMGTSEAAYCGVPVVATPMYGDQFVNTAALVERGMGTILNFEDIG 414
            :||.|:|.||..|.|::|||..|..||.|.|||:|..|::|||..|...|..:|...:|:|..:.
Zfish   354 IPQNDLLGHPKTKAFITHGGTNGLYEAIYHGVPMVGLPLFGDQPDNLMHLKSKGAAVVLDFFTLE 418

  Fly   415 ENTVMRALKKALDK-KFHDAAKVVSHSFHHRPQQALHTAIWWVEHVAHTGGAPLLKPSAVEMSRF 478
            ...::.|||..|:. .:.::...:|...|.:|.:.|..|::|:|.|....||..|:..|.|:|.:
Zfish   419 SKDLVDALKTVLNNPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHELSWY 483

  Fly   479 VYYSLDVYAVLALVLGSIIASWV----WLLRLCCGSSAAQ-KTKKD 519
            .|:.|||.|.|..:...|...||    :|.|.|...:..: |:||:
Zfish   484 QYHCLDVAAFLLSITALITFLWVKACCFLFRRCVRKTRPERKSKKE 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	133/503 (26%)
ugt2a6	NP_001138283.1	UDPGT	21..519	CDD:278624	146/552 (26%)
ugt2a6	NP_001138283.1	egt	<254..485	CDD:223071	75/232 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584373
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930