DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36D1 and ugt5a2

DIOPT Version :9

Sequence 1:	NP_001246082.2	Gene:	Ugt36D1 / 35138	FlyBaseID:	FBgn0032713	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001070191.2	Gene:	ugt5a2 / 767756	ZFINID:	ZDB-GENE-061103-373	Length:	524	Species:	Danio rerio

Alignment Length:	556	Identity:	155/556 - (27%)
Similarity:	259/556 - (46%)	Gaps:	80/556 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VALLFLALALSQPDELVEAAGPLKVLGLFPHPGVSHFHFFHPIMKGLAEAGHDVSVVSHFPDKHP 70
            :.|..|...||:     ..||.|.|:   |..| ||:.....::..|...||.::||     :..
Zfish     7 LGLFLLLCVLSR-----SYAGKLLVV---PVEG-SHWVNMKVLIVELHSRGHSITVV-----RGS 57

  Fly    71 VAHY--KDFPLTGMDKLTNSV-DLKFFEK------------RTFYS---------HFQEFFLLYD 111
            .:.|  :..||.....:.|.| |..|.||            ::|::         ||     :.:
Zfish    58 SSWYIEEQSPLYTSITVDNGVFDDDFMEKFLPHLLKIQRQGKSFWNEMALADEMIHF-----VTE 117

  Fly   112 WGKQTCNLT---LRSEALQQILRRPGRFDVIIMEQFNTDCMMG----VAHQLQAPVIALSSCVMM 169
            ..||:||:|   ..:|.|...| :...:||::     ||...|    :||:|..|::     ..:
Zfish   118 THKQSCNMTAILFENETLMNSL-KDAAYDVVL-----TDPAYGSGVLLAHRLGLPLV-----YNV 171

  Fly   170 PW------HYERMGAPLIPSHIPALFMAQSQHMNFGGRLANWFSTHALNWMY-KLLSVPAADAMV 227
            .|      |::...:||  |::|...:..:..|.|..|:.|..:...:.:.| |....|..:...
Zfish   172 RWTVYGEAHFDIAPSPL--SYVPVSGLQLTDKMTFSQRVMNMMTYIMIRYKYSKNFGSPYQELTQ 234

  Fly   228 QYKFGHDVPSVG--ELVKNTSMFFVNQHYSLSGPKVTPPNVIELGGIHIQKSKPLPADLQRILDN 290
            :| ||   |:|.  .|:::..::.:...::...|:.|.|||:.:||...:.:||||.||:..:.:
Zfish   235 KY-FG---PNVNFFSLLQDADLWLMRNDFTFEFPRPTMPNVVYMGGFQCKPAKPLPGDLEEFVQS 295

  Fly   291 A-EEGVILISWGSMIRANSLSAAKRDGIIRAVARLKQKVIWKWENETLPNQPPNMHIMKWLPQRD 354
            : |.|||::|.|::.  ..|.:...|.|..|.|:|.|||||::......|...|..|:.||||.|
Zfish   296 SGEHGVIMMSLGTVF--GQLLSELNDEIAAAFAQLPQKVIWRYTGPRPANLGNNTLIVNWLPQND 358

  Fly   355 ILCHPNVKVFMSHGGLMGTSEAAYCGVPVVATPMYGDQFVNTAALVERGMGTILNFEDIGENTVM 419
            :|.||..|:|::|||..|..||.|.|||:|..|:..||..|.:.:..:|...|:.|..:.....:
Zfish   359 LLGHPKTKLFVAHGGTNGLQEAIYHGVPIVGLPLAFDQPDNLSRMRAKGTAKIVEFATLDRAVFL 423

  Fly   420 RALKKAL-DKKFHDAAKVVSHSFHHRPQQALHTAIWWVEHVAHTGGAPLLKPSAVEMSRFVYYSL 483
            .|||:.| :..:.:..:.:|...|.:|.:.|..||:|:|.|....|||.|:..:..||...|.|:
Zfish   424 EALKEVLHNPSYRENMQRLSKLHHDQPMKPLDRAIFWIEFVMRNKGAPHLRAQSFRMSWIEYQSI 488

  Fly   484 DVYAVLALVLGSIIASWVWLLRLCCGSSAAQKTKKD 519
            ||...|.|::...:...|:.::..|.....:|.|::
Zfish   489 DVILTLMLMVLVFVLLTVYTMKYFCLCLFRKKVKRE 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	142/502 (28%)
ugt5a2	NP_001070191.2	UDPGT	22..524	CDD:278624	150/534 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584275
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.740